A5043518153- High Altitude and Hypoxia
- Cancer, Hypoxia, and Metabolism
- Adipose Tissue and Metabolism
- Metabolism and Genetic Disorders
- Travel-related health issues
- Genetics and Physical Performance
- Neuroscience of respiration and sleep
- Inflammasome and immune disorders
- Lipid metabolism and disorders
- Inflammatory Bowel Disease
- Climate Change and Health Impacts
- Rangeland Management and Livestock Ecology
- Biomarkers in Disease Mechanisms
- melanin and skin pigmentation
- Bone and Joint Diseases
- Dietary Effects on Health
- Liver Disease Diagnosis and Treatment
- Digestive system and related health
- Cancer-related molecular mechanisms research
- Skin Protection and Aging
- Gout, Hyperuricemia, Uric Acid
- Animal Diversity and Health Studies
- Eicosanoids and Hypertension Pharmacology
- Mitochondrial Function and Pathology
Gansu Provincial Hospital
2024
Tibetan Traditional Medical College
2016-2023
Second Affiliated Hospital of Zhengzhou University
2021
Tibetans are well adapted to the hypoxic environments at high altitude, yet molecular mechanism of this adaptation remains elusive. We reported comprehensive genetic and functional analyses EPAS1, a gene encoding hypoxia inducible factor 2α (HIF-2α) with strongest signal selection in previous genome-wide scans Tibetans. showed that Tibetan-enriched EPAS1 variants down-regulate expression human umbilical endothelial cells placentas. Heterozygous knockout mice display blunted physiological...
Abstract High-altitude adaptation of Tibetans represents a remarkable case natural selection during recent human evolution. Previous genome-wide scans found many non-coding variants under selection, suggesting pressing need to understand the functional role regulatory elements (REs). Here, we generate time courses paired ATAC-seq and RNA-seq data on cultured HUVECs hypoxic normoxic conditions. We further develop variant interpretation methodology (vPECA) identify active selected REs (ASREs)...
Tibetans are genetically adapted to high-altitude environments. Though many studies have been conducted, the genetic basis of adaptation remains elusive due poor reproducibility for detecting selective signatures in Tibetan genomes.
Yak is one of the largest native mammalian species at Himalayas, highest plateau area in world with an average elevation >4,000 m above sea level. well adapted to high altitude environment a set physiological features for more efficient blood flow oxygen delivery under hypobaric hypoxia. Yet, genetic mechanism underlying its adaptation remains elusive. We conducted cross-tissue, cross-altitude, and cross-species study characterize transcriptomic landscape domestic yaks. The generated...
Structural variants (SVs) may play important roles in human adaptation to extreme environments such as high altitude but have been under-investigated. Here, combining long-read sequencing with multiple scaffolding techniques, we assembled a high-quality Tibetan genome (ZF1), contig N50 length of 24.57 mega-base pairs (Mb) and scaffold 58.80 Mb. The ZF1 assembly filled 80 remaining N-gaps (0.25 Mb total length) the reference (GRCh38). Markedly, detected 17 900 SVs, among which ZF1-specific...
Strong ultraviolet (UV) radiation at high altitude imposes a serious selective pressure, which may induce skin pigmentation adaptation of indigenous populations. We conducted phenotyping and genome-wide analysis Tibetans in order to understand the underlying mechanism UV radiation. observe that have darker baseline color compared with lowland Han Chinese, as well an improved tanning ability, suggesting two-level boost their melanin production. A search for responsible genes identifies GNPAT...
ABSTRACT Nitric oxide (NO) is an important molecule for vasomotor tone, and elevated NO signaling was previously hypothesized as a unique adaptive physiological change in highland Tibetans. However, there has been lack of data from Tibetans living at low altitude lowlander immigrants high altitude, which crucial to test this hypothesis. Here, through cross-altitude (1990–5018 m) cross-population (Tibetans Han Chinese) analyses serum metabolites (NOx) 2086 individuals, we demonstrate that...
Domestication and introduction of dairy animals facilitated the permanent human occupation Tibetan Plateau. Yet history pastoralism in Plateau remains poorly understood. Little is known how Tibetans adapted to milk products.We integrated archeological evidence genetic analysis show picture that ruminants, together with dogs, were introduced from West Eurasia into since ~ 3600 years ago. The admixture between exotic indigenous dogs enriched candidate lactase persistence (LP) allele 10974A > G...
Abstract Background Sherpas, a highlander population living in Khumbu region of Nepal, are well known for their superior climbing ability Himalayas. However, the genetic basis adaptation to high‐altitude environments remains elusive. Methods We collected DNA samples 582 Sherpas from Nepal and Tibetan Autonomous Region China, we measured hemoglobin levels degrees blood oxygen saturation. genotyped 29 EPAS 1 SNP s, two EGLN s TED polymorphism (3.4 kb deletion) Sherpas. also performed...
Tibetans are well adapted to high-altitude hypoxia. Previous genome-wide scans have reported many candidate genes for this adaptation, but only a few been studied. Here we report on hypoxia gene ( GCH1, GTP-cyclohydrolase I), involved in maintaining nitric oxide synthetase (NOS) function and normal blood pressure, that harbors potentially adaptive variants Tibetans. We resequenced an 80.8 kb fragment covering the entire region of GCH1 50 unrelated Combined with previously published data,...
: C-reactive protein (CRP) functions as a nonspecific marker in various inflammatory disorders, particularly evaluating the efficacy of pharmacological treatments patients with ulcerative colitis. The existing body evidence does not offer adequate support for direct implication CRP modulating advancement
Abstract Structural variants (SVs) may play important roles in human adaption to extreme environments such as high altitude but have been under-investigated. Here, combining long-read sequencing with multiple scaffolding techniques, we assembled a high-quality Tibetan genome (ZF1), contig N50 length of 24.57 mega-base pairs (Mb) and scaffold 58.80 Mb. The ZF1 assembly filled 80 remaining N-gaps (0.25 Mb total length) the reference (GRCh38). Markedly, detected 17,900 SVs, among which...
Objective: To investigate the association of hyperuricemia-induced renal damage with sirtuin 1 (SIRT1) and endothelial nitric oxide synthase (eNOS) in rats. Methods: Using random number table method, 32 Sprague-Dawley rats were randomly divided into 4 groups: control group, model A group (the was generated using oxonic acid potassium salt alone), B (hyperuricemia combined uric acid) resveratrol 8 each group. The experiment lasted 12 weeks. Serum cystatin C levels monitored regularly. In week...