A5100365190- Cancer, Hypoxia, and Metabolism
- Ocular Oncology and Treatments
- Genomics and Rare Diseases
- Functional Brain Connectivity Studies
- Parkinson's Disease Mechanisms and Treatments
- Glaucoma and retinal disorders
- Genetics and Neurodevelopmental Disorders
- Cancer Research and Treatments
- RNA modifications and cancer
- Gastrointestinal Tumor Research and Treatment
- Genetic Associations and Epidemiology
- Cancer-related molecular mechanisms research
- Alzheimer's disease research and treatments
- Sarcoma Diagnosis and Treatment
- Retinal Diseases and Treatments
- High Altitude and Hypoxia
- Intraocular Surgery and Lenses
- Cancer-related Molecular Pathways
- Cancer, Lipids, and Metabolism
- Mitochondrial Function and Pathology
- Epigenetics and DNA Methylation
- Autism Spectrum Disorder Research
- Advanced MRI Techniques and Applications
- Lysosomal Storage Disorders Research
- Virus-based gene therapy research
Shanghai Chest Hospital
2021-2025
Capital Medical University
2008-2025
Central South University
2015-2025
Sichuan University
2013-2025
West China Hospital of Sichuan University
2013-2025
Beijing Hospital of Traditional Chinese Medicine
2025
Tibet Academy of Agricultural and Animal Husbandry Sciences
2024-2025
First Affiliated Hospital of GuangXi Medical University
2025
Guangxi Medical University
2025
Guiyang Medical University
2025
This study aimed to determine the mutational spectrum of familial Parkinson's disease and sporadic early-onset (sEOPD) in a mainland Chinese population clinical features mutation carriers. We performed multiplex ligation-dependent probe amplification assays whole-exome sequencing for 1676 unrelated patients with population, including 192 probands from families autosomal-recessive disease, 242 autosomal-dominant 1242 sEOPD (age at onset ≤ 50). According standards guidelines American College...
A reductase that removes harmful nitrosyl groups from cellular proteins guards against liver cancer, perhaps in part by ensuring the health of a crucial DNA repair enzyme.
Rheumatoid arthritis (RA) is a systemic autoimmune disease underlying cascade of chronic inflammatory processes. Over the past decades, response rate effective RA treatments has remained scarce despite numerous advancements in current therapeutic interventions, owing largely to associated off-target adverse events and poor accumulation inflamed joints. Recently, there high interest development targeted drug delivery system by using nanotechnology, as it can provide handle improve therapy...
Spinal cord injury (SCI), following explosive oxidative stress, causes an abrupt and irreversible pathological deterioration of the central nervous system. Thus, preventing secondary injuries caused by reactive oxygen species (ROS), as well monitoring assessing recovery from SCI are critical for emergency treatment SCI. Herein, strategy is developed based on selenium (Se) matrix antioxidant system to effectively inhibit stress-induced damage simultaneously real-time evaluate severity using a...
Excessive mechanical strain is the prominent risk factor for osteoarthritis (OA), causing cartilage destruction and degeneration. However, underlying molecular mechanism contributing to signaling transduction remains unclear in OA. Piezo type mechanosensitive ion channel component 1 (Piezo1) a calcium-permeable provides mechanosensitivity cells, but its role OA development has not been determined. Herein, we found up-regulated expression of Piezo1 cartilage, that activation contributes...
Abstract Gastrointestinal stromal tumor (GIST) is the most common sarcoma located in gastrointestinal tract and derived from interstitial cell of Cajal (ICC) lineage. Both ICC GIST cells highly rely on KIT signal pathway. Clinically, about 80-90% treatment-naive patients harbor primary mutations, special KIT-targeted TKI, imatinib (IM) showing dramatic efficacy but resistance invariably occur, 90% them was due to second mutations emerging within gene. Although there are multiple variants...
The modulation of tumor microenvironments through immune checkpoint pathways is pivotal for the development effective cancer immunotherapies. This study aims to explore role HVEM in non-small cell lung (NSCLC) microenvironment. datasets this were directly downloaded from Cancer Genome Atlas (TCGA). Single-cell data sourced Tumor Immune Hub (TISCH). Multiplex immunohistochemistry (mIHC) was used cellular composition and spatial distribution microenvironment KO mice bearing mouse also...
Blood and urine biomarkers are commonly used to diagnose monitor chronic diseases. We initially screened 67 biomarkers, including 4 63 blood identified 13 significantly associated with Parkinson's disease (PD). Among these, we discovered three novel markers demonstrating strong associations: phosphate (P = 1.81 × 10−3), AST/ALT ratio 8.53 10−6), immature reticulocyte fraction (IRF) 3.49 10−20). also substantiated eight well-studied elucidated the roles of two previously ambiguous biomarkers....
Abstract Diffusion tensor imaging (DTI) studies have revealed group differences in white matter between patients with obsessive‐compulsive disorder (OCD) and healthy controls. However, the results of these were based on average two groups, therefore had limited clinical applicability. The objective this study was to investigate whether fractional anisotropy (FA) can be used discriminate OCD controls at level individual. DTI data acquired from 28 demographically matched controls, scanned...
De novo mutations (DNMs) significantly contribute to sporadic diseases, particularly in neuropsychiatric disorders. Whole-exome sequencing (WES) and whole-genome (WGS) provide effective methods for detecting DNMs prioritizing candidate genes. However, it remains a challenge scientists, clinicians, biologists conveniently access analyse data regarding genes from scattered publications. To fill the unmet need, we integrated 580 799 DNMs, including 30 060 coding detected by WES/WGS 23 951...
Abstract Obsessive–compulsive disorder (OCD) is a debilitating and disabling neuropsychiatric disorder, whose neurobiological basis remains unclear. Although traditional static resting‐state magnetic resonance imaging (rfMRI) studies have found aberrant functional connectivity (FC) in OCD, alterations whole‐brain FC topological properties the context of brain dynamics remain relatively unexplored. The rfMRI data 29 patients with OCD 40 healthy controls were analyzed using group independent...
Colorectal liver metastases (CRLMs) are clinically heterogeneous lesions with poor prognosis. Genetic alterations play a crucial role in their progression. The traditional Fong clinical risk score (Fong-CRS) is commonly used for stratification and prognosis prediction. By identifying the genomic of CRLMs, we aimed to develop mutation-based gene-signature-based (mut-CS) system improve prognostication. Tumour tissues from 144 patients CRLMs were analysed next-generation sequencing (NGS). A...
Abstract Substantial evidence shown that the age at onset (AAO) of Parkinson’s disease (PD) is a major determinant clinical heterogeneity. However, mechanisms underlying heterogeneity in AAO remain unclear. To investigate risk factors with PD, total 3156 patients PD from UK Biobank were included this study. We evaluated effects polygenic scores (PRS), nongenetic factors, and their interaction on using Mann–Whitney U tests regression analyses. further identified genes interacting for...
Structural variants (SVs) may play important roles in human adaptation to extreme environments such as high altitude but have been under-investigated. Here, combining long-read sequencing with multiple scaffolding techniques, we assembled a high-quality Tibetan genome (ZF1), contig N50 length of 24.57 mega-base pairs (Mb) and scaffold 58.80 Mb. The ZF1 assembly filled 80 remaining N-gaps (0.25 Mb total length) the reference (GRCh38). Markedly, detected 17 900 SVs, among which ZF1-specific...
Abstract Background There is a lack of large multicenter Parkinson's disease (PD) cohort studies and limited data on the natural history PD in China. Objectives The objective this study was to launch Chinese Disease Registry (CPDR) report its protocol, cross‐sectional baseline data, prospects for comprehensive observational, longitudinal, study. Methods CPDR recruited patients from 19 clinical sites across China between January 2018 December 2020. Clinical were collected prospectively using...
Purpose Macrophages have been shown to play a critical role in the wound healing process. In present study, of macrophages after autologous corneal transplantation was investigated by depleting local infiltrated macrophages. Methods Autologous model used induce repair Balb/c mice. were depleted sub-conjunctival injections clodronate-containing liposomes (Cl2MDP-LIP). The presence CD11b+ F4/80+ macrophages, α-smooth muscle actin+ (α-SMA+) myofibroblasts, CD31+ vascular endothelial cells and...