A5035164430- Malaria Research and Control
- Aquaculture Nutrition and Growth
- Autism Spectrum Disorder Research
- Genetics and Neurodevelopmental Disorders
- Viral Infections and Vectors
- Vector-borne infectious diseases
- Marine Bivalve and Aquaculture Studies
- Invertebrate Immune Response Mechanisms
- Genomic variations and chromosomal abnormalities
- Aquaculture disease management and microbiota
- Genetic diversity and population structure
- Genomics and Rare Diseases
- Aquatic Invertebrate Ecology and Behavior
- Genetics, Aging, and Longevity in Model Organisms
- Mosquito-borne diseases and control
- Radiopharmaceutical Chemistry and Applications
- Genetic and phenotypic traits in livestock
- Corneal surgery and disorders
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Genetic Associations and Epidemiology
- Physiological and biochemical adaptations
- interferon and immune responses
- Ophthalmology and Visual Impairment Studies
- Muscle Physiology and Disorders
Henan University of Science and Technology
2025
Luoyang Institute of Science and Technology
2025
Central South University
2015-2024
Yantai Institute of Coastal Zone Research
2020-2024
Yantai University
2023-2024
Shanghai Jiao Tong University
2024
Northwest A&F University
2024
Chinese Academy of Fishery Sciences
2015-2023
Xiangya Hospital Central South University
2021-2023
National Institute of Allergy and Infectious Diseases
2018-2023
Abstract Recurrent de novo (DN) and likely gene-disruptive (LGD) mutations contribute significantly to autism spectrum disorders (ASDs) but have been primarily investigated in European cohorts. Here, we sequence 189 risk genes 1,543 Chinese ASD probands (1,045 from trios). We report an 11-fold increase the odds of DN LGD compared with expectation under exome-wide neutral model mutation. In aggregate, ∼4% patients carry a mutation one just 29 genes. The most prevalent gene for recurrent is...
We previously performed targeted sequencing of autism risk genes in probands from the Autism Clinical and Genetic Resources China (ACGC) (phase I). Here, we expand this analysis to a larger cohort patients (ACGC phase II) better understand prevalence, inheritance, genotype-phenotype correlations likely gene-disrupting (LGD) mutations for candidate originally identified cohorts European descent.We sequenced 187 an additional 784 85 599 using single-molecule molecular inversion probes. tested...
In the practical farming of Litopenaeus vannamei, intensive culture system and environmental pollution usually results in a high concentration ammonia, which brings large detrimental effects to shrimp, such as increasing susceptibility pathogens, reducing growth, decreasing osmoregulatory capacity, molting frequency, even causing mortality. However, little information is available on molecular mechanisms ammonia stress shrimp. this study, we performed comparative transcriptome analysis...
<h3>Background</h3> High myopia, with the characteristic feature of refractive error, is one leading causes blindness worldwide. It has a high heritability, but only few causative genes have been identified and pathogenesis still unclear. <h3>Methods</h3> We used whole genome linkage exome sequencing to identify mutation in non-syndromic myopia family. Direct Sanger was screen candidate gene additional sporadic cases or probands. Immunofluorescence evaluate expression pattern process eye...
Abstract Autism spectrum disorder (ASD) describes a group of neurodevelopmental disorders with high heritability, although the underlying genetic determinants ASDs remain largely unknown. Large-scale whole-genome studies copy number variation in Han Chinese samples are still lacking. We performed genome-wide analysis 343 ASD trios, 203 patients sporadic cases and 988 controls population using Illumina genotyping platforms to identify CNVs related genes that may contribute risk. identified 32...
De novo mutations (DNMs) significantly contribute to sporadic diseases, particularly in neuropsychiatric disorders. Whole-exome sequencing (WES) and whole-genome (WGS) provide effective methods for detecting DNMs prioritizing candidate genes. However, it remains a challenge scientists, clinicians, biologists conveniently access analyse data regarding genes from scattered publications. To fill the unmet need, we integrated 580 799 DNMs, including 30 060 coding detected by WES/WGS 23 951...
Infection by malaria parasites triggers dynamic immune responses leading to diverse symptoms and pathologies; however, the molecular mechanisms responsible for these reactions are largely unknown. We performed Trans-species Expression Quantitative Trait Locus analysis identify a large number of host genes that respond parasite infections. Here we functionally characterize one called receptor transporter protein 4 (RTP4) in virus RTP4 is induced type I IFN (IFN-I) binds TANK-binding kinase...
Malaria infection induces complex and diverse immune responses. To elucidate the mechanisms underlying host-parasite interaction, we performed a genetic screen during early (24 h) Plasmodium yoelii in mice identified large number of interacting host parasite genes/loci after transspecies expression quantitative trait locus (Ts-eQTL) analysis. We next investigated E3 ubiquitin ligase gene (March1) that was clustered with interferon (IFN)-stimulated genes (ISGs) based on similarity genome-wide...
Insertion and Deletion (InDel) are common features in genomes associated with genetic variation. The whole-genome re-sequencing data from two parents (X1 X2) of the elite cucumber (Cucumis sativus) hybrid variety Lvmei No.1 was used for genome-wide InDel polymorphisms analysis. Obtained sequence reads were mapped to genome reference Chinese fresh market type inbred line '9930' gaps conforming pinpointed. Further, level cross-parents polymorphism among five pairs breeding their corresponding...
Aluminosilicates, such as montmorillonite, kaolinite, halloysite, and diatomite, have a uniform bidimensional structure, high surface-to-volume ratio, inherent stiffness, dual charge distribution, chemical inertness, biocompatibility, abundant active groups on the surface, silanol (Si-OH) and/or aluminol (Al-OH) groups. These compounds are list of U.S. Food Drug Administration-approved excipients used for various medicinal products, wound healing agents, antidiarrheals, cosmetics. This...
Abstract Non-coding variants in the human genome significantly influence traits and complex diseases via their regulation modification effects. Hence, an increasing number of computational methods are developed to predict effects non-coding sequences. However, it is difficult for inexperienced users select appropriate from dozens available methods. To solve this issue, we assessed 12 performance metrics 24 on four independent variant benchmark datasets: (1) rare germline clinical relevant...
The CRISPR/Cas12a system has revolutionized nucleic acid detection through trigger-activated nonspecific trans-cleavage activity. Enhancing this activity is vital for improving the sensitivity of CRISPR/Cas biosensing systems. Although various chemical enhancers have been shown to affect Cas12a ribonucleoprotein (RNP), underlying mechanisms remain poorly understood. Investigating how these alter structure RNPs essential elucidating enhancement involved. This study focuses on structural...