A5100420219- Renal cell carcinoma treatment
- Prostate Cancer Treatment and Research
- Epigenetics and DNA Methylation
- Phagocytosis and Immune Regulation
- Prostate Cancer Diagnosis and Treatment
- Renal and related cancers
- Cancer Genomics and Diagnostics
- Ferroptosis and cancer prognosis
- Parkinson's Disease Mechanisms and Treatments
- Cancer Immunotherapy and Biomarkers
- Cancer, Lipids, and Metabolism
- Pancreatic and Hepatic Oncology Research
- Urologic and reproductive health conditions
- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Neurological disorders and treatments
- Heat Transfer and Boiling Studies
- Radiopharmaceutical Chemistry and Applications
- Nuclear Receptors and Signaling
- PARP inhibition in cancer therapy
- Neuroscience and Neuropharmacology Research
- Advanced Optimization Algorithms Research
- RNA regulation and disease
- Genetic Neurodegenerative Diseases
- Cannabis and Cannabinoid Research
Sichuan University
2016-2025
West China Hospital of Sichuan University
2016-2025
Xiangya Hospital Central South University
2016-2025
Central South University
2016-2025
Hangzhou Hospital of Traditional Chinese Medicine
2024-2025
Henan University of Technology
2024
Shanghai Medical Information Center
2024
Nanjing University of Aeronautics and Astronautics
2023
Wuhou District People's Hospital, Chengdu
2023
Hubei University of Medicine
2022
This study aimed to determine the mutational spectrum of familial Parkinson's disease and sporadic early-onset (sEOPD) in a mainland Chinese population clinical features mutation carriers. We performed multiplex ligation-dependent probe amplification assays whole-exome sequencing for 1676 unrelated patients with population, including 192 probands from families autosomal-recessive disease, 242 autosomal-dominant 1242 sEOPD (age at onset ≤ 50). According standards guidelines American College...
Abstract TFE3 -translocation renal cell carcinoma ( -tRCC) is a rare and heterogeneous subtype of kidney cancer with no standard treatment for advanced disease. We describe comprehensive molecular characteristics 63 untreated primary -tRCCs based on whole-exome RNA sequencing. -tRCC highly heterogeneous, both clinicopathologically genotypically. ASPSCR1-TFE3 fusion several somatic copy number alterations, including the loss 22q, are associated aggressive features poor outcomes. Apart from...
Abstract Endocannabinoid (eCB), 2 -arachidonoyl-glycerol (2-AG), the most abundant eCB in brain, regulates diverse neural functions. Here we linked multiple homozygous loss-of-function mutations 2-AG synthase diacylglycerol lipase β ( DAGLB ) to an early onset autosomal recessive Parkinsonism. is main human and mouse substantia nigra (SN) dopaminergic neurons (DANs). In mice, SN levels were markedly correlated with motor performance during locomotor skill acquisition. Genetic knockdown of...
Genome-wide association studies (GWASs) have identified numerous susceptibility loci for Parkinson's disease (PD), but its genetic architecture remains underexplored in populations of non-European ancestry. To identify variants associated with PD the Chinese population, we performed a GWAS using whole-genome sequencing (WGS) 1,972 cases and 2,478 controls, replication study total 8209 9454 controls. We one new risk variant rs61204179 (P
Parkinson's disease causes the most profound loss of aldehyde dehydrogenase 1A1-positive (ALDH1A1+) nigrostriatal dopaminergic neuron (nDAN) subpopulation. The connectivity and functionality ALDH1A1+ nDANs, however, remain poorly understood. Here, we show in rodent brains that nDANs project predominantly to rostral dorsal striatum, from which they also receive monosynaptic inputs, indicating extensive reciprocal innervations with striatal spiny projection neurons (SPNs). Functionally,...
Abstract Background Intraductal carcinoma of the prostate (IDC-P) is a subtype cancer featured by poor prognosis. Previous studies suggested IDC-P could have potentially unstable genome. Homologous recombination deficiency (HRD) score result-oriented method to describe genomic instability status. This study investigates association HRD scores with and other clinicopathological factors prognostic implication in an aggressive cohort. Methods involved 123 PCa patients, including high-risk...
Fumarate hydratase-deficient renal cell carcinoma (FH-RCC) is a rare highly aggressive subtype of kidney cancer for which the distinct genomic, transcriptomic, and evolutionary relationships between metastatic primary lesions are still unclear.
Green and sustainable electrochemical conversion storage devices possess the nature to repress a negative effect on sustainability during energy storage. However, of devices' components themselves (e.g., raw material abundance, eco-friendliness, recycling) is often ignored, which may damage environment limit practical applicability. Herein, guided by concept sustainability, strategy reported synthesize very cheap single zinc atoms dispersed nitrogen-doped hierarchically porous carbon...
The modification of DNA by phosphorothioate (PT) occurs when the non-bridging oxygen in sugar-phosphate backbone is replaced with sulfur. This was recently discovered and governed dndABCDE genes a diverse group bacteria archaea. However, biological function PT modifications poorly understood. In this study, we employed RNA-seq analysis to characterize global transcriptional changes response modifications. Our results show that without protection susceptible damage caused dndFGHI gene...
Multidisciplinary team (MDT) discussion is a widely used model to manage patients diagnosed with cancer. However, there has been no direct evidence prove its effect on the prognosis of metastatic renal cell carcinoma (mRCC) patients, so this study explored impact MDT mRCC patient survival.The clinical data 269 were retrospectively collected from 2012 2021. The cases grouped into and non-MDT groups, then subgroup analysis was performed according different histology types, as well exploring...
Metastatic castration-resistant prostate cancer (CRPC) is a currently incurable disease associated with high mortality. Novel therapeutic approaches for CRPC are urgently needed to improve prognosis. In this study, we developed cross-linked, PSMA-targeted lipoic acid nanoparticles (cPLANPs), which can interact transmembrane glycoprotein accumulate inside cells, where they upregulate caspase-3, downregulate anti-apoptotic B-cell lymphoma-2 (BCL-2), and thereby induce apoptosis. The...
Prostate-specific membrane antigen (PSMA) is highly expressed on the surface of most prostate tumor cells and considered a promising target for cancer imaging treatment. It possible to establish PSMA-targeted theranostic probe achieve early diagnosis treatment this type. In contribution, we prepared multifunctional melanin-like polydopamine (PDA) nanocarrier decorated with small-molecule PSMA inhibitor, N-[N-[(S)-1,3-dicarboxypropyl]carbamoyl]-(S)-l-lysine (DCL). PDA-DCL was then...
Objectives To investigate the genetic alterations of patients with prostate cancer (PCa) and without intraductal carcinoma (IDC‐P). Patients Methods We performed targeted sequencing plasma cell‐free DNA on 161 adenocarcinoma (PAC) IDC‐P 84 IDC‐P. Genomic were compared between these two groups. The association patients’ survival outcomes was also explored. Results identified that 29.8% (48/161) 21.4% (18/84) harboured genomic in repair pathways, respectively ( P = 0.210). Pathogenic germline...
Purpose: The aim of this study was to investigate the effect general anesthesia combined with transversus abdominis plane block on postoperative sleep disorders in elderly patients undergoing gastrointestinal tumor surgery. Methods: For malignant tumors, we recruited 94 patients, aged 65– 80, who were scheduled for radical laparoscopic Using random number table method, randomly divided into two groups, group (group GA) and GT). GA received sedation-aspiration complex regimen, while GT...
Model quantization is widely applied for compressing and accelerating deep neural networks (DNNs). However, conventional Quantization-Aware Training (QAT) focuses on training DNNs with uniform bit-width. The bit-width settings vary across different hardware transmission demands, which induces considerable storage costs. Hence, the scheme of one-shot joint multiple precisions proposed to address this issue. Previous works either store a larger FP32 model switch between precision models higher...
ABSTRACT Background The prognostic value of the prostate adenocarcinoma (PAC) with ductal feature in patients advanced cancer treated abiraterone acetate has not been scrutinized. This study aims to explore predictive PAC on therapeutic efficacy therapy metastatic (mPCa) patients. Methods We retrospectively analyzed data from 569 mPCa receiving at either hormone‐sensitive (mHSPC, N = 165) or castration‐resistant (mCRPC, 404) stage. PSM was performed balance baseline characteristics between...
Objective Despite substantial advancements in uncovering the genetic basis of Parkinson's disease (PD), a significant portion cases characterized by familial PD remain genetically elusive. Here, we reported that biallelic variants EPG5 , key autophagy gene responsible for Vici syndrome, are associated with PD. Methods Whole‐exome sequencing (WES) was performed first cohort including 171 pedigrees autosomal recessive (ARPD), 1,746 sporadic early‐onset (sEOPD, age at onset ≤ 50 years) and...