A5057641523- Prostate Cancer Treatment and Research
- Renal cell carcinoma treatment
- Urinary Bladder and Prostate Research
- Renal and related cancers
- Urological Disorders and Treatments
- Marine and coastal ecosystems
- Respiratory viral infections research
- Ferroptosis and cancer prognosis
- Immunotherapy and Immune Responses
- Pancreatic and Hepatic Oncology Research
- Hormonal and reproductive studies
- Neurogenesis and neuroplasticity mechanisms
- RNA Interference and Gene Delivery
- Influenza Virus Research Studies
- Cancer-related gene regulation
- Digital and Cyber Forensics
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer, Lipids, and Metabolism
- Heart Rate Variability and Autonomic Control
- Cybercrime and Law Enforcement Studies
- Traditional Chinese Medicine Studies
- Epigenetics and DNA Methylation
- Urinary Tract Infections Management
- Nuclear and radioactivity studies
- Cancer Genomics and Diagnostics
Ministry of Agriculture and Rural Affairs
2022-2025
Anhui Agricultural University
2025
First Affiliated Hospital of Kunming Medical University
2025
Kunming Medical University
2025
Southwest Hospital
2015-2025
Lanzhou University
2022-2025
Army Medical University
2016-2025
Lanzhou University of Technology
2025
Shenzhen University
2020-2024
East China University of Political Science and Law
2008-2024
Ischemic injury can induce neurogenesis in the striatum. Those newborn neurons express glutamic acid decarboxylase and choline acetyltransferase, markers of GABAergic cholinergic neurons, respectively. The present study investigated whether these new could differentiate into functional cells.Retrovirus containing EGFP gene was used to label dividing cells striatal slices prepared from adult rat brains after middle cerebral artery occlusion. EGFP-targeted immunostaining immunoelectron...
A dielectric elastomer is capable of giant electromechanical actuation but fails at breakdown due to instability under certain conditions with a small deformation. By applying mechanical pre-stretch, one obtains stabilized large actuation. In this paper, we measured the constant and critical voltage polyacrylic subjected both equal unequal biaxial stretch, modelled its by employing Gent strain energy function microscopic view characterize nonlinear stiffening behaviour electrostrictive...
Clear cell renal carcinoma (ccRCC) is a common malignant tumour of the urinary tract. The major causes poor prognosis are lack early diagnosis and metastasis. Accumulating research reveals that circular RNAs (circRNAs) can play key roles in development progression cancer. However, role circRNAs ccRCC still uncertain.The microarray (n = 4) was performed to investigate with differential expression tissues. candidate circRNA selected based on cut-off criteria, such as abundance, size design...
Abstract Background Clear cell renal carcinoma (ccRCC) is the most prevalent kidney cancer with high aggressive phenotype and poor prognosis. Accumulating evidence suggests that circRNAs have been identified as pivotal mediators in cancers. However, role of ccRCC progression remains elusive. Methods The differentially expressed 4 paired human adjacent noncancerous tissues were screened using circRNA microarrays candidate target was selected based on expression level weighted gene correlation...
ABSTRACT Currently, an effective treatment for spinal cord injury (SCI) is not available. Due to the irreversible primary associated with SCI, prevention and of secondary are very important. In stage, pyroptosis exacerbates deterioration injury, inhibiting beneficial recovery from SCI. The aim this study was clarify role resveratrol (RES) antipyroptotic mechanisms RES miR‐124‐3p in SCI lay a theoretical foundation clinical provide new therapeutic approaches. Using cell staining related...
Fumarate hydratase-deficient renal cell carcinoma (FH-deficient RCC) is a rare yet highly lethal kidney cancer. To deepen our understanding of FH-deficient RCC, we conduct comprehensive integrated genomic study. We analyze the association FH alteration patterns with tumor heterogeneity and develop CpG site-specific methylation signature for precise identification RCC. Transcriptomic analysis unveils three distinctive molecular subtypes characterized by enrichment immune/Angiogenic/Stromal...
Mounting evidence suggests that there is a close association between chronic sleep deprivation (CSD) and cognitive deficits. The animal model of CSD-induced deficits commonly used to seek potential treatments. Soy isoflavones (SI) have been reported possess antioxidant, anti-inflammation, neuroprotective effects. In the present study, effects SI on memory impairment were investigated. mice subjected interruption apparatus continuously deprived for 2 weeks, while orally administrated with...
Fumarate hydratase-deficient renal cell carcinoma (FH-RCC) is a rare highly aggressive subtype of kidney cancer for which the distinct genomic, transcriptomic, and evolutionary relationships between metastatic primary lesions are still unclear.
Because of their viscoelasticity, dielectric elastomers (DEs) are able to produce a large time-dependent electromechanical deformation. In the current study, we use Euler-Lagrange equation characterize influence temperature, excitation frequency, and viscoelasticity on dynamic deformation stability viscoelastic dielectrics. We investigate performance, hysteresis, phase diagram, Poincaré map associated with dissipative process. The results show that response has strong temperature frequency...
Nasopharyngeal carcinoma (NPC) is known for high curability during early stage of the disease, and diagnosis relies on nasopharyngeal endoscopy subsequent pathological biopsy. To enhance rate by aiding physicians in real-time identification NPC directing biopsy site selection endoscopy, we assembled a dataset comprising 2,429 video frames from 690 patients across three medical centers. With these data, developed deep learning-based detection model using you only look once (YOLO) network. Our...
Abstract This paper aims to disclose the evolutionary mechanism of banks' green credit and construction demolition waste (CDW) recycling enterprises' technology innovation behavior during operation period CDW public–private partnership projects with absorptive capacity theory. The conclusions are as follows. First, government subsidy coefficient has a positive effect on evolution banks participate in credit. Second, level collaboration have enterprises collaborative innovation. Third,...
Abstract African American (AA) men exhibit a relatively high incidence and mortality due to prostate cancer even after adjustment for socioeconomic factors, but the biological basis this disparity is unclear. Here, we identify novel region on chromosome 4p16.3 that lost selectively in AA cancer. The negative regulator of G-protein signaling RGS12 was defined as target deletions, although it has not been implicated previously tumor-suppressor gene. transcript levels were reduced cancer, cell...
Abstract Background Clear cell renal carcinoma (ccRCC) is an immunologically and histologically diverse tumor. However, how the structural heterogeneity of tumor microenvironment (TME) affects cancer progression treatment response remains unclear. Hence, we characterized TME architectures ccRCC tissues using imaging mass cytometry (IMC) explored their associations with clinical outcome therapeutic response. Methods Using IMC, profiled landscape paracancerous tissue by measuring 17 markers...
This study aimed to identify the differential expression levels of androgen receptor (AR), estrogen receptors (ERα, ERβ), and progesterone (PGR) between normal prostate benign prostatic hyperplasia (BPH). The combination immunohistochemistry, quantitative real-time reverse transcription polymerase chain reaction, Western blotting assay was used distribution these at immunoactive biomarker, transcriptional, protein 5 human tissues 40 BPH tissues. results were then validated in a rat model...
Discrete oligo- and polyesters are highly attractive for a wide range of investigations because their great fidelity on structure–property relationships. Even though numerous synthetic approaches have been developed, more versatile platform with broad group tolerance is still desired. Herein, we report an iterative exponential growth strategy efficient synthesis discrete polyesters, employing optimized protective pair, namely, TBDPS ether t-butyl ester. The versatility the demonstrated by...
This study developed and validated an adaptive treatment control system based on affine transformation for accelerator-based boron neutron capture therapy. Accelerator-based therapy is a form of targeted radiotherapy that uses boron-10 to label tumor cells. When these boron-rich cells interact with neutrons, they produce high-linear energy transfer alpha particles lithium-7 particles, effectively destroying the precision. The newly integrates real-time stereoscopic x-ray imaging technology,...
Depression is highly prevalent in patients suffering from chronic inflammatory diseases. Dysregulated neuroinflammation and concomitant-activated microglia play a pivotal role the pathogenesis of depression. As one biologically functional phytochemicals soybeans, soy isoflavones (SI) have been reported to exhibit anti-inflammatory, antioxidant, estrogen-like neuroprotective activities. However, there no research on how SI administration affects depressive-like behavior induced by...
No AccessJournal of UrologyInvestigative Urology1 Sep 2011Oxalate Impairs Aminophospholipid Translocase Activity in Renal Epithelial Cells Via Oxidative Stress: Implications for Calcium Oxalate Urolithiasis Shi-Liang Yu, Xiu-Guo Gan, Jin-Ming Huang, Yan Cao, Yong-Quan Wang, Shang-Ha Pan, Li-Yan Ma, Yue-Qiu Teng, and Rui-Hua An YuShi-Liang Yu Department Urology, First Affiliated Hospital Harbin Medical University, Harbin, People's Republic China , GanXiu-Guo Gan HuangJin-Ming Huang CaoYan Cao...