A5101911235- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Cutaneous Melanoma Detection and Management
- Cutaneous lymphoproliferative disorders research
- Nonmelanoma Skin Cancer Studies
- Cerebrovascular and Carotid Artery Diseases
- Colorectal and Anal Carcinomas
- Acoustic Wave Resonator Technologies
- Cancer Immunotherapy and Biomarkers
- Metal and Thin Film Mechanics
- Biochemical and Structural Characterization
- FOXO transcription factor regulation
- Intracranial Aneurysms: Treatment and Complications
- RNA Research and Splicing
- vaccines and immunoinformatics approaches
- Circular RNAs in diseases
- Machine Learning in Bioinformatics
- Cardiac electrophysiology and arrhythmias
- Bladder and Urothelial Cancer Treatments
- Wnt/β-catenin signaling in development and cancer
- PARP inhibition in cancer therapy
- Structural Health Monitoring Techniques
- Peptidase Inhibition and Analysis
- Ultrasonics and Acoustic Wave Propagation
Harbin Medical University
2008-2025
Third Affiliated Hospital of Harbin Medical University
2008-2025
Blind and Sight Impaired Society
2024
First Hospital of Jilin University
2024
Jilin University
2024
Shenzhen Polytechnic
2020
Xiamen University
2015
Previous randomized clinical trials did not demonstrate the superiority of endovascular stenting over aggressive medical management for patients with symptomatic intracranial atherosclerotic stenosis (sICAS). However, balloon angioplasty has been investigated in a trial.
Abstract Background Previous studies have suggested that trauma may be a risk factor for the development and prognosis of acral melanoma (AM). Methods This population-based retrospective cohort study included patients with AM confirmed history who received treatment at 5 centers in China. Factors associated recurrence survival were analyzed using univariate multivariate Cox regression analyses. Results Totally 468 cases this study, 101 group 367 non-trauma group. The had more ulceration (P =...
e21558 Background: High-dose interferon-alpha-2b (HD-IFN) has an important place in the adjuvant treatment of acral melanoma (AM). However, studies on AM with HD-IFN remain limited. This retrospective study aimed to evaluate relationships between dosing regimen during intensification phase, duration treatment, and interval surgery first dose postoperative recurrence survival patients. Methods: A total 113 patients were included this study, including 2 stage 0, 7 IA, 5 unknown stage. The...
4536 Background: Dual immune checkpoint inhibitors (ICIs) or ICIs plus VEGF-directed therapies, have been approved as first-line treatment in patients (pts) with advanced renal cell carcinoma (RCC). The phase 3 ETER100 trial showed that benmelstobart (PD-L1 blockade) anlotinib improved the progression-free survival (PFS) (19.0 months 9.8 months) and objective response rate (ORR) (71.6% vs 25.1%) of clear RCC (ccRCC) pts significantly. Pts factors, such intermediate-poor International...
Axis inhibition protein 2 (Axin2) is a negative regulator of the canonical Wnt/β-catenin signaling pathway, and functions as tumor suppressor in number human cancers. Previous pilot studies have suggested an association between Axin2 exon1 148 (rs2240308) SNP polymorphism risk for lung cancer. In present study, we aimed to investigate its with cancer susceptibility Han Chinese population. The was genotyped 555 controls 520 patients using TaqMan Genotyping Assays. Unconditional logistic...
Kv1.5 (also known as KCNA5) is a protein encoded by the KCNA5 gene, which belongs to voltage-gated potassium channel, shaker-related subfamily. Recently, number of studies have suggested that overexpressed in numerous cancers and plays crucial roles cancer development. However, until now, expression functions osteosarcoma are still unclear. To characterize potential biological osteosarcoma, herein, we examined levels cells tissues using quantitative real-time polymerase chain reaction...
Angiotensin II (Ang II) stimulates tumor growth and angiogenesis in some solid cancer cells, but its anti-apoptosis role breast remains unclear. To address this issue, we investigated the effect of Ang on adriamycin-induced apoptosis MCF-7 cells. Treatment human cells with adriamycin, a DNA topoisomerase alpha inhibitor, caused apoptosis. However, pretreated were resistant to significantly reduced ratio apoptotic stimulation phospho-Akt-Thr308 phospho-Akt-Ser473 dose-dependent time-dependent...
Non-classically secreted proteins (NCSPs) are that located in the extracellular environment, although there is a lack of known signal peptides or secretion motifs. They usually perform different biological functions intracellular and environments, several their linked to bacterial virulence cell defence. Accurate protein localization essential for all living organisms, however, performance existing methods developed NCSP identification has been unsatisfactory particular suffer from data...
Protocadherin-10 (PCDH10) is a tumor suppressor gene. Its expression level downregulated by promoter methylation in certain types of human tumors. The aim the present study was to examine and status PCDH10 breast cancer cells evaluate association progression prognosis. MethyLight used detect tissues healthy tissues. Reverse transcription-quantitative polymerase chain reaction assess mRNA PCDH10, as well between clinicopathological features, along with patients' overall survival (OS)....
Melanoma is one of the most aggressive and life-threatening skin cancers, in this research, we aimed to explore functional role circular RNA VANGL1 (circVANGL1) melanoma progression. The expression levels circVANGL1 were observed be significantly increased clinical tissues cell lines. Moreover, knockdown suppressed, while overexpression promoted proliferation, migration invasion abilities cells. Further investigations confirmed direct binding relation between miR-150-5p melanoma, restoration...
504 Background: Patients with advanced metastatic urothelial carcinoma (UC) who experience disease progression after standard therapy have limited treatment options. Phase I studies of toripalimab in subjects heavily pretreated UC demonstrated an acceptable safety profile and promising clinical activity. Here we report the preliminary efficacy result a II study Chinese patients refractory/metastatic (Clinical trial ID: NCT03113266). Methods: Metastatic received toripalimab, also known as...
Abstract Background： Previous studies have suggested that trauma may be a risk factor for the development and prognosis of acral melanoma (AM), but available evidence is limited.This study aimed to explore impact on AM recurrence survival. Methods： This population-based retrospective cohort included patients with clear history who were treated at five treatment centers in China from 2009 2023. Data analyzed July 2023 August Baseline characteristics two groups using chi-square test....