A5027863139- Glioma Diagnosis and Treatment
- Immune cells in cancer
- Bacteriophages and microbial interactions
- Monoclonal and Polyclonal Antibodies Research
- Pancreatic and Hepatic Oncology Research
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Single-cell and spatial transcriptomics
- Transportation and Mobility Innovations
- Cancer, Hypoxia, and Metabolism
- Mitochondrial Function and Pathology
- Cellular Mechanics and Interactions
- Neonatal Respiratory Health Research
- Nutritional Studies and Diet
- Bioinformatics and Genomic Networks
- Cancer Immunotherapy and Biomarkers
- Circular RNAs in diseases
- Lung Cancer Treatments and Mutations
- Escherichia coli research studies
- Renal cell carcinoma treatment
- Neonatal and Maternal Infections
- Alkaline Phosphatase Research Studies
- Sodium Intake and Health
- Menopause: Health Impacts and Treatments
Jilin University
2023-2024
Southwest Hospital
2017-2024
Army Medical University
2017-2024
Hainan Branch of People's Liberation Army General Hospital
2022-2024
Chinese People's Liberation Army
2024
National University of Singapore
2024
People's Liberation Army No. 150 Hospital
2024
First Hospital of Jilin University
2023
Jilin Medical University
2023
Chinese PLA General Hospital
2023
Monocyte-derived tumor-associated macrophages (Mo-TAMs) intensively infiltrate diffuse gliomas with remarkable heterogeneity. Using single-cell transcriptomics, we chart a spatially resolved transcriptional landscape of Mo-TAMs across 51 patients isocitrate dehydrogenase (IDH)-wild-type glioblastomas or IDH-mutant gliomas. We characterize Mo-TAM subset that is localized to the peri-necrotic niche and skewed by hypoxic cues acquire hypoxia response signature. Hypoxia-TAM destabilizes...
Abstract Glioblastoma (GBM) is a prevalent and highly lethal form of glioma, with rapid tumor progression frequent recurrence. Excessive outgrowth pericytes in GBM governs the ecology perivascular niche, but their function mediating chemoresistance has not been fully explored. Herein, we uncovered that potentiate DNA damage repair (DDR) cells residing which induces temozolomide (TMZ) chemoresistance. We found increased pericyte proportion correlates accelerated recurrence worse prognosis....
Glioblastoma (GB) is the most common and highly malignant brain tumor characterized by aggressive growth resistance to alkylating chemotherapy. Autophagy induction one of hallmark effects anti-GB therapies with temozolomide (TMZ). However, non-classical form autophagy, autophagy-based unconventional secretion, also called secretory autophagy its role in regulating sensitivity GB TMZ remains unclear. There an urgent need illuminate mechanism develop novel therapeutic targets for GB.Cancer...
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal disease harboring significant microenvironment heterogeneity, especially for the macrophages. Tumor-associated macrophages (TAMs) orchestrate PDAC malignancy, but their dynamics during progression remains poorly understood. There pressing need to identify molecular mechanism underlying tumor-macrophage interactions and thus design novel therapeutic strategies.Herein, we developed an insilico computational method incorporating bulk...
Plastic phenotype convention between glioma stem cells (GSCs) and non-stem tumor (NSTCs) significantly fuels glioblastoma heterogeneity that causes therapeutic failure. Recent progressions indicate glucose metabolic reprogramming could drive cell fates. However, the pattern of GSCs NSTCs its association with phenotypes remain largely unknown. Here we found were more glycolytic than NSTCs, voltage-dependent anion channel 2 (VDAC2), a mitochondrial membrane protein, was critical for switching...
Objective: Glioblastoma (GBM) is the most common primary malignant brain tumor regulated by numerous genes, with poor survival outcomes and unsatisfactory response to therapy. Therefore, a robust, multi-gene signature-derived model required predict prognosis treatment in GBM. Methods: Gene expression data of GBM from TCGA GEO datasets were used identify differentially expressed genes (DEGs) through DESeq2 or LIMMA methods. The DEGs then overlapped for analysis univariate multivariate COX...
Background: Basal-like breast cancer (BLBC) is the most aggressive subtype of (BC) and links to poor outcomes. As molecular mechanism BLBC has not yet been completely discovered, identification key pathways hub genes this disease an important way for providing new insights into exploring mechanisms initiation progression. Objective: The aim study was identify potential gene signatures development progression via bioinformatics analysis. Methods results: differential expressed (DEGs)...
Tumour-associated macrophages (TAMs) abundantly infiltrate high-grade gliomas and orchestrate immune response, but their diversity in isocitrate dehydrogenase (IDH)-differential grade 4 remains largely unknown. This study aimed to dissect the transcriptional states, spatial distribution, clinicopathological significance of distinct monocyte-derived TAM (Mo-TAM) microglia-derived (Mg-TAM) clusters across glioblastoma-IDH-wild type astrocytoma-IDH-mutant-grade (Astro-IDH-mut-G4). Single-cell...
Glioblastoma (GBM) is an aggressive primary brain tumor with unique immunity predominated by myeloid cells. GBM cells have been implicated to evade immune attack through hijacking myeloid-affiliated transcriptional programs establish immunosuppressive microenvironment. However, molecular features of immune-evading in heterogeneous GBMs and their interactions remain unclear. Herein, we employed single-cell RNA sequencing (scRNA-seq) bulk RNA-seq data develop silico method for delineating...
Immune checkpoint inhibitors (ICIs) have been an encouraging treatment method in non‑small cell lung cancer (NSCLC). However, bone and liver metastases are considered to restrain immunotherapy efficacy. Since serum alkaline phosphatase (ALP) is associated with metastases, it was investigated whether ALP could be a novel biomarker predict the efficacy of ICIs treatment. In present study, 143 patients NSCLC receiving were retrospectively analyzed. The objective response rate (ORR) compared...
Glioblastoma (GBM) is the most common and lethal primary brain tumor characterized by extensive vascularization. Anti-angiogenic therapy for this cancer offers possibility of universal efficacy. However, preclinical clinical studies suggest that anti-VEGF drugs, such as Bevacizumab, actively promote invasion, which ultimately leads to a therapy-resistant recurrent phenotype GBMs. Whether Bevacizumab can improve survival over chemotherapy alone remains debated. Herein, we emphasize importance...
Individuals living with metabolic syndrome (MetS) such as diabetes and obesity are at high risk for developing chronic kidney disease (CKD). This study investigated the beneficial effect of whole grape powder (WGP) diet on MetS-associated CKD. Obese diabetic ZSF1 rats, a model MetS, were fed WGP (5%, w/w) six months. Kidney was determined using blood urine chemical analyses, histology. When compared to Vehicle controls, intake did not change rat bodyweight, but lowered their kidney, liver...
Necrotizing enterocolitis (NEC) is the most common and frequently dangerous neonatal gastrointestinal disease. Studies have shown broad-spectrum antibiotics plus anaerobic antimicrobial therapy did not prevent deterioration of NEC among very low birth preterm infants. However, few studies about this which focused on full-term near-term infant with has been reported. The aim study was to evaluate effect antibiotic metronidazole in preventing from stage II III A retrospective cohort based...
Ovarian cancer, ranking as the seventh most prevalent malignancy among women globally, faces significant challenges in diagnosis and therapeutic intervention. The difficulties early detection are amplified by limitations inefficacies inherent current screening methodologies, highlighting a pressing need for more efficacious diagnostic treatment strategies. Phage display technology emerges pivotal innovation this context, utilizing extensive phage-peptide libraries to identify ligands with...
Glioblastoma multiforme (GBM) is a highly aggressive brain tumor with poor progrnosis and high recurrence rate after surgery. To this end, we examined the role of Nanog that expressed in tumor. NANOG transcription factor involved pluripotency embryonic stem cells (ESCs) induction malignancy cancer stem-like (CSCs). Bioinformatic analysis revealed may be associated development traits GBM. Forced expression markedly increased cell markers promoted sphere formation migration GBM cells. enhanced...