A5031784842- Immune cells in cancer
- Glioma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- RNA Interference and Gene Delivery
- Reproductive System and Pregnancy
- Cytokine Signaling Pathways and Interactions
- Advanced Memory and Neural Computing
- Medicinal Plant Pharmacodynamics Research
- Immune Response and Inflammation
- Biopolymer Synthesis and Applications
- Hydrocarbon exploration and reservoir analysis
- Immune Cell Function and Interaction
- Animal Genetics and Reproduction
- Nutrition, Genetics, and Disease
- Molecular Biology Techniques and Applications
- Neuroscience and Neural Engineering
- Circular RNAs in diseases
- bioluminescence and chemiluminescence research
- RNA Research and Splicing
- Pancreatic and Hepatic Oncology Research
- Photoreceptor and optogenetics research
- Chemokine receptors and signaling
Collaborative Innovation Center of Advanced Microstructures
2025
Nanjing University
2025
China National Petroleum Corporation (China)
2024
Army Medical University
2014-2021
Southwest Hospital
2014-2021
Chongqing Medical University
2012-2016
Children's Hospital of Chongqing Medical University
2015
Tumor-associated macrophages (TAMs) are essential cellular components within tumor microenvironment (TME). TAMs educated by TME to transform M2 polarized population, showing a M2-like phenotype, IL-10high, IL-12low, TGF-βhigh. STAT3 signaling triggers crosstalk between cells and TAMs, is crucial for the regulation of malignant progression. In our study, legumain-targeting liposomal nanoparticles (NPs) encapsulating HC were employed suppress activity "re-educate" investigate effects...
Background Information: Previous studies have revealed that leptin may be involved in epithelial-mesenchymal transition (EMT), a crucial initiator of cancer progression to facilitate metastatic cascade, increase tumor recurrence, and ultimately cause poor prognosis. However, the underlying mechanism remains unclear. The aim our present study was investigate effect on EMT breast cells mechanism. Results: Our data demonstrated significantly increased phosphorylation STAT3, Akt, ERK1/2,...
This study aims to investigate the mechanisms underlying leptin-mediated crosstalk between tumor-associated macrophages (M2 macrophages) and breast cancer cells. THP1 human leukemic monocytes were induced differentiate into M2 by PMA (100 nM) IL-4 (20 ng/mL). Quantitative RT-PCR Western blot revealed that leptin significantly increased expression of receptor (ObR) in (P < 0.01) stimulated interleukin (IL)-8 macrophages, mouse macrophage cells RAW264.7, primary peritoneal a dose-...
Objective: Glioblastoma (GBM) is the most common primary malignant brain tumor regulated by numerous genes, with poor survival outcomes and unsatisfactory response to therapy. Therefore, a robust, multi-gene signature-derived model required predict prognosis treatment in GBM. Methods: Gene expression data of GBM from TCGA GEO datasets were used identify differentially expressed genes (DEGs) through DESeq2 or LIMMA methods. The DEGs then overlapped for analysis univariate multivariate COX...
Abstract Aims The aim of this study was to investigate the tumor microenvironment immune types (TMIT) based on cell programmed death ligand 1 (PD‐L1) expression and tumor‐infiltrating lymphocytes (TILs) distribution whether distinct TMIT subtypes (TMIT I, PD‐L1 high /TIL ; II, low III, IV, ) differentially affect clinical outcomes patients with lung adenocarcinoma (LAC) squamous carcinoma (SCC). Methods results Immunohistochemistry (IHC) applied evaluate spatial (PD‐1) CD8 TILs surgically...
Abstract Background The existing cell surface markers used for sorting glioma stem cells (GSCs) have obvious limitations, such as vulnerability to the enzymatic digestion and time-consuming labeling procedure. Reduced nicotinamide adenine dinucleotide (NADH) a cellular metabolite with property of autofluorescence has potential be new biomarker GSCs. Methods A method GSCs was established according properties NADH. Then, NADH high low subpopulations were sorted. stem-like evaluated by qRT-PCR,...
In-memory computing hardware based on memristors has emerged as a promising option for scientific due to its large-scale parallel data processing capability. However, the nonuniformity issue of renders practical deployment in-memory complex, requiring peripheral circuits ensure accuracy computing, thereby resulting in increased power consumption. Here, we present mortise-tenon-shaped (MTS) memristor with ultrahigh uniformity by introducing mortise-shaped h-BN flake HfO2 switching layer. The...
Considering the importance of gene expression studies for understanding biology glioma stem cells (GSCs), we aimed to identify reliable reference genes in GSCs that were derived from cell lines T98G, LN229, 090116 and 091214. Quantitative real-time reverse-transcription PCR was employed using 11 identified through a PubMed literature search, assessment stability geNorm, Normfinder coefficient variation methods performed select suitable genes. We found HPRT1 RPL13A most genes, validated...
The lithology distribution of fine-grained sedimentary rocks in regional space plays a crucial role guiding the exploration oil shale layers.Identifying by conventional logging information is efficient and costeffective.However, strong inhomogeneity leads to complex nonlinear relationship between data, making linear methods no longer applicable.This study proposes hybrid model for identification from first member Qingshankou Formation Songliao Basin, NE China.This based on kernel extreme...