A5100662197- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Diagnosis and Treatment
- Aortic Disease and Treatment Approaches
- Aortic aneurysm repair treatments
- Cardiac Valve Diseases and Treatments
- Cancer Genomics and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Abdominal Surgery and Complications
- Renal cell carcinoma treatment
- CAR-T cell therapy research
- Lung Cancer Research Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Infectious Aortic and Vascular Conditions
- Hernia repair and management
- Immunotherapy and Immune Responses
- Extracellular vesicles in disease
- Monoclonal and Polyclonal Antibodies Research
- interferon and immune responses
- MRI in cancer diagnosis
- Pancreatic and Hepatic Oncology Research
- Venous Thromboembolism Diagnosis and Management
Central South University
2016-2025
Second Xiangya Hospital of Central South University
2014-2025
Nanjing Medical University
2024-2025
The First People’s Hospital of Lianyungang
2021-2025
Wuhan University
2023-2025
Shanghai Jiao Tong University
2022-2025
Kangda College of Nanjing Medical University
2025
Xuzhou Medical College
2022-2025
Songjiang District Central Hospital
2025
Xiangya Hospital Central South University
2013-2024
Nivolumab, a programmed death (PD)-1 (PD-1) inhibitor, led to durable responses, manageable safety, and increased survival in patients with advanced hepatocellular carcinoma (HCC). In our retrospective analysis, we studied the immunobiology potential associations between biomarkers outcomes nivolumab HCC.Fresh archival tumour samples from dose-escalation dose-expansion phases of CheckMate 040 trial were analysed by immunohistochemistry RNA sequencing assess several inflammatory gene...
To date, estrogen is the only known endogenous receptor (ER) ligand that promotes ER+ breast tumor growth. We report cholesterol metabolite 27-hydroxycholesterol (27HC) stimulates MCF-7 cell xenograft growth in mice. More importantly, cancer patients, 27HC content normal tissue increased compared to cancer-free controls, and further elevated. Increased correlated with diminished expression of CYP7B1, metabolizing enzyme, reduced CYP7B1 tumors associated poorer patient survival. Moreover,...
Inflammatory mediators, including acute phase reactants and cytokines, have been reported to be associated with clinical efficacy in patients melanoma other cancers receiving immune checkpoint inhibitors (ICI). Analyses of patient sera from three large II/III randomized ICI trials, one which included a chemotherapy arm, were performed assess whether baseline levels C-reactive protein (CRP), interleukin-6 (IL-6) or neutrophil/lymphocyte (N/L) ratios prognostic predictive.Baseline on-treatment...
Ipilimumab and nivolumab have each shown treatment benefit for high-risk resected melanoma. The phase III CheckMate 915 trial evaluated adjuvant plus ipilimumab versus alone in patients with stage IIIB-D or IV melanoma.In this randomized, double-blind, trial, 1,833 received 240 mg once every 2 weeks 1 mg/kg 6 (916 patients) 480 4 (917 ≤ year. After random assignment, were stratified by tumor programmed death ligand (PD-L1) expression stage. Dual primary end points recurrence-free survival...
Open-label phase II study (RELATIVITY-060) to investigate the efficacy and safety of first-line nivolumab, a PD-1-blocking antibody, plus relatlimab, lymphocyte-activation gene 3 (LAG-3)-blocking chemotherapy in patients with previously untreated advanced gastric cancer (GC) or gastroesophageal junction (GEJC).
Abstract: Regeneration deficiency is one of the main obstacles limiting effectiveness tissue-engineered scaffolds. To develop scaffolds that are capable accelerating regeneration, we created a heparin/chitosan nanoparticle-immobilized decellularized bovine jugular vein scaffold to increase loading capacity and allow for controlled release vascular endothelial growth factor (VEGF). The vascularization was evaluated in vitro vivo. functional nanoparticles were prepared by physical...
Background Information: Previous studies have revealed that leptin may be involved in epithelial-mesenchymal transition (EMT), a crucial initiator of cancer progression to facilitate metastatic cascade, increase tumor recurrence, and ultimately cause poor prognosis. However, the underlying mechanism remains unclear. The aim our present study was investigate effect on EMT breast cells mechanism. Results: Our data demonstrated significantly increased phosphorylation STAT3, Akt, ERK1/2,...
Abstract Outcomes for patients with melanoma have improved over the past decade as a result of development and FDA approval immunotherapies targeting cytotoxic T lymphocyte antigen-4 (CTLA-4), programmed death-1 (PD-1), death ligand 1 (PD-L1). However, these therapies do not benefit all patients, an area intensive research investigation is identifying biomarkers that can predict which are most likely to from them. Here, we report exploratory analyses associations tumor mutational burden...
Abstract Background Coronavirus disease (COVID-19) has become a pandemic. The knowledge, attitudes, and practices (KAP) of the public play major role in prevention control infectious diseases. objective present study was to evaluate KAP Chinese assess potential influencing factors related practices. Methods A cross-sectional online survey conducted China February 2020 via self-designed questionnaire comprising 33 questions assessing KAP. Results For 2136 respondents from 30 provinces or...
Abstract The development of strain sensors with high stretchability and stability is an inevitable requirement for achieving full‐range long‐term use wearable electronic devices. Herein, a resistive micromesh reinforced sensor (MRSS) prepared, consisting laser‐scribed graphene (LSG) layer two styrene‐block‐poly(ethylene‐ran‐butylene)‐block‐poly‐styrene layers embedded in Ecoflex. structure endows the MRSS combined characteristics (120%), excellent (with repetition error 0.8% after 11 000...
Quantitative high-throughput screening (qHTS) assays are increasingly being used to inform chemical hazard identification. Hundreds of chemicals have been tested in dozens cell lines across extensive concentration ranges by the National Toxicology Program collaboration with Institutes Health Chemical Genomics Center.Our goal was test a hypothesis that dose-response data points qHTS can serve as biological descriptors assayed and, when combined conventional descriptors, improve accuracy...
Rheumatoid arthritis (RA) affects millions world-wide. While anti-TNF treatment is widely used to reduce disease progression, fails in ∼one-third of patients. No biomarker currently exists that identifies non-responders before treatment. A rigorous community-based assessment the utility SNP data for predicting efficacy RA patients was performed context a DREAM Challenge (http://www.synapse.org/RA_Challenge). An open challenge framework enabled comparative evaluation predictions developed by...
519 Background: Approximately 4% of metastatic colorectal cancers (mCRCs) are associated with high microsatellite instability (MSI-H), indicating a deficient DNA mismatch repair (dMMR) system. dMMR/MSI-H CRC exhibits an increased tumor neoantigen load and immune cell infiltration is hypothesized to be targetable by checkpoint inhibitors. CheckMate 142 (NCT02060188) evaluates the efficacy safety nivolumab (nivo) in patients (pts) mCRC. Methods: Pts mCRC who progressed on/were intolerant ≥1...
Wearable sensors have garnered considerable interest from humans over the past decades owing to their broad application prospects and huge development potential. Yet limited number of reliable noninvasive wearable has greatly hindered progress in field health management. Because its good adaptability, physiology significance abundant biomarkers, oral cavity, as one ideal positions for monitoring using sensors, is suitable diverse biomedical applications. This paper presents a review...
Abstract Background Immune cells that infiltrate lesions are important for atherosclerosis progression and immunotherapies. This study was aimed at gaining new insights into the heterogeneity of these by integrating sequencing results multiple samples using an enhanced single-cell workflow to overcome limitations a single study. Results Integrative analyses identified 28 distinct subpopulations based on gene expression profiles. Further analysis demonstrated manifested high levels tissue...