A5089104361- Pancreatic and Hepatic Oncology Research
- Phagocytosis and Immune Regulation
- Angiogenesis and VEGF in Cancer
- Cancer, Hypoxia, and Metabolism
- Cell Adhesion Molecules Research
- Cancer Research and Treatments
- Immune cells in cancer
- Cancer Cells and Metastasis
- Bone and Dental Protein Studies
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Epigenetics and DNA Methylation
- TGF-β signaling in diseases
- Proteoglycans and glycosaminoglycans research
- RNA modifications and cancer
- Protease and Inhibitor Mechanisms
- Cancer Genomics and Diagnostics
- Nanoplatforms for cancer theranostics
- Pancreatic function and diabetes
- Fibroblast Growth Factor Research
- Cell death mechanisms and regulation
- Glycosylation and Glycoproteins Research
- Cancer, Stress, Anesthesia, and Immune Response
- Microtubule and mitosis dynamics
- Peptidase Inhibition and Analysis
The University of Texas Southwestern Medical Center
2016-2025
Southwestern Medical Center
2015-2024
Harold C. Simmons Comprehensive Cancer Center
2008-2024
ScienceSouth
2024
The Radiosurgery Society
2023
University of Bergen
2014-2022
Columbia University Irving Medical Center
2022
Texas Oncology
2022
Molecular Biology Consortium
2021
Cancer Genetics (United States)
2016-2021
Adipose tissue can undergo rapid expansion during times of excess caloric intake. Like a rapidly expanding tumor mass, obese adipose becomes hypoxic due to the inability vasculature keep pace with growth. Consequently, early stages obesity, conditions cause an increase in level hypoxia-inducible factor 1alpha (HIF1alpha) expression. Using transgenic model overexpression constitutively active form HIF1alpha, we determined that HIF1alpha fails induce expected proangiogenic response. In...
Obese fat pads are frequently undervascularized and hypoxic, leading to increased fibrosis, inflammation, ultimately insulin resistance. We hypothesized that VEGF-A-induced stimulation of angiogenesis enables sustained sufficient oxygen nutrient exchange during mass expansion, thereby improving adipose tissue function. Using a doxycycline (Dox)-inducible adipocyte-specific VEGF-A overexpression model, we demonstrate the local up-regulation in adipocytes improves vascularization causes...
Recent studies have identified a unique cancer-associated fibroblast (CAF) population termed antigen-presenting CAFs (apCAFs), characterized by the expression of major histocompatibility complex class II molecules, suggesting function in regulating tumor immunity. Here, integrating multiple single-cell RNA-sequencing and performing robust lineage-tracing assays, we find that apCAFs are derived from mesothelial cells. During pancreatic cancer progression, cells form downregulating features...
To date, estrogen is the only known endogenous receptor (ER) ligand that promotes ER+ breast tumor growth. We report cholesterol metabolite 27-hydroxycholesterol (27HC) stimulates MCF-7 cell xenograft growth in mice. More importantly, cancer patients, 27HC content normal tissue increased compared to cancer-free controls, and further elevated. Increased correlated with diminished expression of CYP7B1, metabolizing enzyme, reduced CYP7B1 tumors associated poorer patient survival. Moreover,...
Pancreatic ductal adenocarcinoma (PDA) is a major cause of cancer-related death with limited therapeutic options available. This highlights the need for improved understanding biology PDA progression, highly complex and dynamic process featuring changes in cancer cells stromal cells. A comprehensive characterization cell heterogeneity during disease progression lacking. In this study, we aimed to profile populations understand their phenotypic progression. To that end, employed single-cell...
The exploration of new physical and chemical properties materials their innovative application in different fields are great importance to advance analytical chemistry, material science, other important fields. Herein, we, for the first time, discovered photothermal effect an iron oxide nanoparticles (NPs)-mediated TMB (3,3′,5,5′-tetramethylbenzidine)-H2O2 colorimetric system, applied it toward development a NP-mediated immunoassay platform visual quantitative biomolecule detection using...
Although the tumor stroma in solid tumors like gastric cancer (GC) plays a crucial role chemo-resistance, specific targets to inhibit interaction between stromal and cells have not yet been utilized clinical practice. The present study aims determine whether cancer-associated fibroblasts (CAFs), major component of stroma, confer chemotherapeutic resistance GC cells, discover potential improve chemo-response GC. To identify CAF-specific proteins signal transduction pathways affecting...
Here we report the discovery of a characteristic dense vascular network (DVN) in tip portion epididymal adipose tissue adult mice. The DVN is formed by angiogenesis rather than vasculogenesis, and has functional blood circulation. This its subsequent branching may provide new route for adipogenesis. recruitment, infiltration, accumulation bone marrow-derived LYVE-1 + macrophages region are crucial formation DVN. Matrix metalloproteinases (MMPs) VEGF-VEGFR2 system responsible not only DVN,...
Abstract Purpose: New strategies to detect tumor angiogenesis and monitor response of vasculature therapy are needed. Contrast ultrasound imaging using microbubbles targeted endothelium offers a noninvasive method for monitoring quantifying vascular effects antitumor therapy. We investigated the use follow in mouse model pancreatic adenocarcinoma. Experimental Design: Microbubbles conjugated monoclonal antibodies were used image quantify two different therapies s.c. orthotopic tumors mice....
Steroid hormone receptors function classically in the nucleus as transcription factors. However, recent data indicate that there are also non-nuclear subpopulations of steroid receptors, including estrogen (ERs), mediate membrane-initiated signaling unclear basis and significance. Here we have shown an estrogen-dendrimer conjugate (EDC) is excluded from stimulates endothelial cell proliferation migration via ERα, direct ERα-Gαi interaction, NOS (eNOS) activation. Analysis mice carrying...
Background Activating mutations in one allele of an oncogene (heterozygous mutations) are widely believed to be sufficient for tumorigenesis. However, mutant specific imbalance (MASI) has been observed tumors and cell lines harboring oncogenes. Methodology/Principal Findings We determined 1) mutational status, 2) copy number gains (CNGs) 3) relative ratio between wild type alleles KRAS, BRAF, PIK3CA EGFR genes by direct sequencing quantitative PCR assay over 400 human tumors, lines,...
We report a two-color, cell-based screen to identify specific receptor-binding compounds in combinatorial library of peptoids displayed on beads. apply this strategy the isolation vascular endothelial growth factor receptor 2 (VEGFR2)-binding peptoids. A dimeric derivative one these lead is shown be an antagonist VEGFR2 activity both vitro and vivo. This methodology provides potentially general route synthetic molecules that bind integral membrane receptors with affinities specificities...