A5050809443- Immune cells in cancer
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Glioma Diagnosis and Treatment
- Angiogenesis and VEGF in Cancer
- T-cell and B-cell Immunology
- Single-cell and spatial transcriptomics
- Extracellular vesicles in disease
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Cancer, Hypoxia, and Metabolism
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer Cells and Metastasis
- Helicobacter pylori-related gastroenterology studies
- Tryptophan and brain disorders
- Cancer, Lipids, and Metabolism
- Cell Adhesion Molecules Research
- Inflammatory Biomarkers in Disease Prognosis
- Flavonoids in Medical Research
Children's Hospital of Fudan University
2022-2025
University of Hong Kong
2020-2025
University of Hong Kong - Shenzhen Hospital
2020-2025
Sun Yat-sen University
2015-2025
Sun Yat-sen University Cancer Center
2017-2025
Zhejiang University
2024-2025
Jinhua Academy of Agricultural Sciences
2025
Ministry of Science ICT and Future Planning
2025
Cornell University
2008-2024
Guangxi Medical University
2012-2024
Abstract The tumor microenvironment (TME) of nasopharyngeal carcinoma (NPC) harbors a heterogeneous and dynamic stromal population. A comprehensive understanding this tumor-specific ecosystem is necessary to enhance cancer diagnosis, therapeutics, prognosis. However, recent advances based on bulk RNA sequencing remain insufficient construct an in-depth landscape infiltrating cells in NPC. Here we apply single-cell 66,627 from 14 patients, integrated with clonotype identification T B cells....
Abstract Background Epidermal growth factor receptor (EGFR)-mutated lung cancer constitutes a major subgroup of non-small cell (NSCLC) and osimertinib is administrated as first-line treatment. However, most patients with treatment eventually relapse within one year. The underlying mechanisms resistance remain largely unexplored. Methods Exosomes isolation was performed by differential centrifugation. Co-culture assays were conducted to explore the alteration drug sensitivity viability...
Pretreatment hematological markers of inflammatory response have emerged as prognostic factors for patients with cancer. In this study, we evaluated the significance various hematologic parameters in nasopharyngeal carcinoma (NPC).Clinical data from 251 NPC were retrospectively collected. Neutrophil counts, lymphocyte platelet neutrophil-lymphocyte ratio (NLR), and platelet-lymphocyte (PLR) adopted potential biomarkers. The Kaplan-Meier method log-rank test to calculate compare...
Abstract Glioblastoma (GBM) is a prevalent and highly lethal form of glioma, with rapid tumor progression frequent recurrence. Excessive outgrowth pericytes in GBM governs the ecology perivascular niche, but their function mediating chemoresistance has not been fully explored. Herein, we uncovered that potentiate DNA damage repair (DDR) cells residing which induces temozolomide (TMZ) chemoresistance. We found increased pericyte proportion correlates accelerated recurrence worse prognosis....
Background Cancer vaccines are able to achieve tumor-specific immune editing in early-phase clinical trials. However, the infiltration of cytotoxic T cells into immune-deserted tumors is still a major limiting factor. An optimized vaccine approach induce antigen-specific that can perform robust tumor important accelerate their translation. We previously developed STING-activating PC7A nanovaccine produces strong anti-tumor cell response on subcutaneous injection. This study systematically...
Immune checkpoint inhibitors (ICIs) have induced durable clinical responses in a subset of patients with colorectal cancer (CRC). However, the dis-satisfactory response rate and lack appropriate biomarkers for selecting suitable to be treated ICIs pose major challenge current immunotherapies. Inflammation-related molecule A20 is closely related immune response, but effect on "eat-me" signal immunotherapy efficacy remains elusive. We found that downregulation prominently improved antitumor...
Abstract Background Special AT ‐rich binding protein‐1 ( SATB 1) reprograms chromatin organization and transcription profiles to promote tumour growth metastasis. Aims This study aimed confirm the effects of 1 on metastasis liver cancer its specific regulation mechanism. Methods expression was evaluated in human hepatoma tissue, adjacent noncancerous tissue seven kinds cell lines. Cell cycle, proliferation, apoptosis eptithelial‐mesenchymal transition EMT ) investigated after enhanced or...
Idiopathic pulmonary fibrosis (IPF) is characterized by excessive deposition of extracellular matrix in the lung with fibroblast-to-myofibroblast transition, leading to chronically compromising function and death. However, very little known about metabolic alterations fibroblasts IPF, there still a lack pharmaceutical agents target dysregulation. Here we show glycolysis upregulation fatty acid oxidation (FAO) downregulation from fibrotic lung, perturbation FAO affects transdifferentiation....
Despite the great success of immunotherapy in a small subset cancer patients, most colorectal (CRC) patients do not respond to programmed cell death receptor 1 (PD-1) blockade immunotherapy. There is an urgent medical need elucidate how cells evade immune response and develop novel means boost efficacy checkpoint inhibitors. In this study, alcohol induces ligand (PD-L1) expression CRC vitro vivo. Alcohol exposure shown induce aldehyde dehydrogenase 2 (ALDH2) that crucial enzyme involved...
Vascular dementia (VD) is the second most common syndrome worldwide, and effective treatments are lacking. Gastrodia elata Blume (GEB) has been used in traditional Chinese herbal medicine for centuries to treat cognitive impairment, ischemic stroke, epilepsy, dizziness. Gastrodin (p-hydroxymethylphenyl-b-D-glucopyranoside, Gas) Gastrodigenin (p-hydroxybenzyl alcohol, HBA) main bioactive components of GEB. This study explored effects Gas HBA on dysfunction VD their possible molecular...
Circulating tumor cells (CTCs) are precursors of distant metastasis in a subset cancer patients. A better understanding CTCs heterogeneity and how these survive during hematogenous dissemination could lay the foundation for therapeutic prevention metastasis. It remains elusive evade immune surveillance elimination by cells. In this study, we unequivocally identified subpopulation shielded with extracellular vesicle (EVs)-derived CD45 (termed as
Thrombopoietic cells may differentially promote or inhibit tissue vascularization by releasing both pro- and antiangiogenic factors. However, the molecular determinants controlling angiogenic phenotype of thrombopoietic remain unknown. Here, we show that expression release thrombospondins (TSPs) megakaryocytes platelets function as a major switch. TSPs inhibited thrombopoiesis, diminished bone marrow microvascular reconstruction following myelosuppression, limited extent revascularization in...
Radiotherapy with or without concurrent chemotherapy is the standard treatment for nasopharyngeal carcinoma (NPC) patients, whose efficacy limited partly by intrinsic and acquired radioresistance. DNA methyltransferase 3B (DNMT3B) has been reported to participate in tumorigenesis via methylation, but its role mediating progression radioresistance of NPC remains unclear. Therefore, we conducted following studies explore relationship between DNMT3B NPC. Here, found that was elevated tissues...
Tumour-associated macrophages (TAMs) abundantly infiltrate high-grade gliomas and orchestrate immune response, but their diversity in isocitrate dehydrogenase (IDH)-differential grade 4 remains largely unknown. This study aimed to dissect the transcriptional states, spatial distribution, clinicopathological significance of distinct monocyte-derived TAM (Mo-TAM) microglia-derived (Mg-TAM) clusters across glioblastoma-IDH-wild type astrocytoma-IDH-mutant-grade (Astro-IDH-mut-G4). Single-cell...
Abstract Metastasis is the most prevalent cause of cancer deaths, and immunological components tumor microenvironment, especially tumor‐associated macrophages (TAMs), play a vital role in metastasis. However, underlying mechanisms TAMs on non‐small‐cell lung (NSCLC) metastasis remain largely unexplored. Herein, we demonstrated that M2‐like facilitate migration invasion cells vitro vivo through intercellular delivery macrophage‐derived exosomes (M2‐exos). Importantly, found M2‐exos had...
This study profiled global single cell-spatial-bulk transcriptome landscapes of hepatocellular carcinoma (HCC) ecosystem from six HCC cases and a non-carcinoma liver control donor. We discovered that intratumoral heterogeneity mainly derived cells diversity pervaded the genome-transcriptome-proteome-metabolome network. are core driving force taming tumor-associated macrophages (TAMs) with pro-tumorigenic phenotypes for favor its dominant growth. Remarkably, M1-types TAMs had been...
Abstract The proliferation‐specific Forkhead box M1 (FoxM1) transcription factor is overexpressed in cancer cells and acts as an important regulator of cell growth survival. Here, we show the molecular mechanisms by which hypoxia regulate FoxM1 expression cells. When were subjected to (1% O 2 ), mRNA protein levels had a significant increase (HepG2, MCF‐7, HeLa). Such was due direct binding hypoxia‐inducible 1 (HIF‐1) HIF‐1 sites promoter. By deletion mutation assays, demonstrated that...