A5101939602- Biomarkers in Disease Mechanisms
- Neuroscience and Neural Engineering
- Ferroptosis and cancer prognosis
- Neurological Disease Mechanisms and Treatments
- Cardiac Ischemia and Reperfusion
- Cancer Mechanisms and Therapy
- Drug Transport and Resistance Mechanisms
- Atherosclerosis and Cardiovascular Diseases
- Circular RNAs in diseases
- Pharmacological Effects and Assays
- Alzheimer's disease research and treatments
- T-cell and B-cell Immunology
- Systemic Lupus Erythematosus Research
- Biological and pharmacological studies of plants
- Trace Elements in Health
- Traditional Chinese Medicine Analysis
- Medicinal Plants and Bioactive Compounds
- Cell death mechanisms and regulation
- Acute Lymphoblastic Leukemia research
- Connective Tissue Growth Factor Research
- Bladder and Urothelial Cancer Treatments
- Nuclear Receptors and Signaling
- Microbial Inactivation Methods
- Hormonal and reproductive studies
- MicroRNA in disease regulation
Huazhong University of Science and Technology
2020-2024
Wuhan Children's Hospital
2020-2024
Central Hospital of Wuhan
2024
Kunming Medical University
2021-2023
Gannan Medical University
2022
Zhongnan Hospital of Wuhan University
2020-2021
Wuhan University
2020-2021
Southern Medical University
2017
The Affiliated Yongchuan Hospital of Chongqing Medical University
2015
Chongqing Medical University
2015
Vascular dementia (VD) is the second most common syndrome worldwide, and effective treatments are lacking. Gastrodia elata Blume (GEB) has been used in traditional Chinese herbal medicine for centuries to treat cognitive impairment, ischemic stroke, epilepsy, dizziness. Gastrodin (p-hydroxymethylphenyl-b-D-glucopyranoside, Gas) Gastrodigenin (p-hydroxybenzyl alcohol, HBA) main bioactive components of GEB. This study explored effects Gas HBA on dysfunction VD their possible molecular...
Testosterone alleviates symptoms in patients with ischaemic heart disease. Androgen receptors are present the heart, and testosterone upregulates gene expression of cardiac beta(1)-adrenoceptors. We hypothesize that may confer cardioprotection by interacting adrenoceptors.In isolated perfused hearts ventricular myocytes from orchidectomized rats without or (200 microg/100 g) replacement, we first determined effect ischaemia/reperfusion presence noradrenaline (10(-7) M). Then contribution...
Systemic lupus erythematosus (SLE) is characterized by abnormal activated T cells, autoreactive B and massive cytokines. The CD4+ cells determined B-cells differentiation cytokines production. programmed death 1 (PD-1) the checkpoint immunoinhibitory receptor of its engagement could exhaust cells. In this study, we investigated role PD-1 systemic with PD-L1-Ig in lupus-like nephritis SLE mice.The murine was injected into SLE-prone mice. proteinuria survival ratio were monitored. production...
Liver fibrosis is the intermediate process and inevitable stage of development chronic liver disease into cirrhosis. Reducing degree plays an extremely important role in treating preventing cirrhosis cancer. The formation affected by iron deposition to a certain extent, excessive further induces Herein, confocal microbeam X-ray fluorescence (μ-XRF) was used determine intensity biodistribution at different time points induced thioacetamide (TAA) rats. To our best knowledge, this first study...
This study aims to originate agenomic instability-derived risk index (GIRI) for prognostic analysis of clear cell renal carcinoma (ccRCC) and explore the mutation characteristics, immune immunotherapy response defined by GIRI. Differentially expressed genome instability-associated genes were obtained from genomic unstable (GU) group stable (GS) group. Rigorous screening conditions assigned hub genes, which then used generate GIRI through multivariate Cox regression analysis. The selected...
To analyze the short-term clinical efficacy and safety of arsenic trioxide (ATO) combined with a modified N7 induction regimen in treatment children high-risk neuroblastoma (NB).
Objective To explore the possible risk factors of death in children with acute lymphoblastic leukemia (ALL) after treatment. Methods The clinical data 31 newly diagnosed and dead treatment Hematology Oncology Department Wuhan children's Hospital from January 1, 2016 to December 31, 2019 were retrospectively analyzed. Univariate factor analysis multivariate Cox regression used analyze each indexes ALL children, causes Results Among 230 (13.4%) cases dead. them, there 12 male 19 female....
To reveal the molecular mechanism of antagonistic effect traditional Chinese medicine Tianma formula (TF) on dementia including vascular (VaD) and Alzheimer's disease (AD) to provide a scientific basis for study prevention treatment dementia.The TF was derived from concerted application medicine. We detected pharmacological in VaD rats. The examined by APP/PS1 mice vivo, Caenorhabditis elegans (C. elegans) vitro, ELISA, pathological assay via HE staining, transcriptome. Based RNA-seq...
Abstract Background: To provide molecular markers and potential targeted therapy for diabetic nephropathy by screening hubgenes based on bioinformatic analysis. Results: We found 91 differentially expressed genes (DEGs) between tissues normal kidney tissues. Majority DEGs were significantly enriched in the extracellular matrix structural constituent, collagen-containing matrix. KEGG pathway analysis showed that most of participated PI3K-Akt signaling pathway, AGE-RAGE complications. Five...