A5071362652- Epigenetics and DNA Methylation
- Autophagy in Disease and Therapy
- RNA modifications and cancer
- Gastrointestinal motility and disorders
- Cancer-related Molecular Pathways
- Nanoplatforms for cancer theranostics
- Immune cells in cancer
- Lung Cancer Treatments and Mutations
- Endoplasmic Reticulum Stress and Disease
- Reproductive System and Pregnancy
- Biomarkers in Disease Mechanisms
- Congenital gastrointestinal and neural anomalies
- Cell death mechanisms and regulation
- Genomics, phytochemicals, and oxidative stress
- Cancer Mechanisms and Therapy
- Corneal Surgery and Treatments
- Autism Spectrum Disorder Research
- Genetics and Neurodevelopmental Disorders
- Cancer, Hypoxia, and Metabolism
- Protease and Inhibitor Mechanisms
- Effects of Radiation Exposure
- Skin and Cellular Biology Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Silk-based biomaterials and applications
- Histone Deacetylase Inhibitors Research
Chengdu Medical College
2023-2025
Army Medical University
2008-2023
Chengdu Military General Hospital
2011-2018
117th Hospital of People's Liberation Army
2001-2011
CAE (Canada)
2008
Shanghai Institutes for Biological Sciences
2002
Chinese Academy of Sciences
2002
The pathological mechanisms of radiation ulcer remain unsolved and there is currently no effective medicine. Here, we demonstrate that persistent DNA damage foci cell senescence are involved in development. Further more, identify cordycepin, a natural nucleoside analogue, as potent drug to block (skin, intestine, tongue) rats/mice by preventing through the increase NRF2 nuclear expression (the assay used mainly on skin). Finally, cordycepin also revealed activate AMPK binding with α1 γ1...
Abstract Pro-inflammatory activation of adipose tissue macrophages (ATMs) is causally linked to obesity and obesity-associated disorders. A number studies have demonstrated the crucial role mitochondrial metabolism in macrophage activation. However, there a lack pharmaceutical agents target ATMs for treatment obesity-related diseases. Here, we characterize near-infrared fluorophore (IR-61) that preferentially accumulates mitochondria has therapeutic effect on diet-induced as well insulin...
Abstract Multidrug resistance-associated protein 3 (MRP3, ABC subfamily C [ABCC]3) plays an important role in protecting hepatocytes and other tissues by excreting array of toxic organic anion conjugates, including bile salts. MRP3/ABCC3 expression is increased the liver some cholestatic patients, but molecular mechanism this up-regulation remains elusive. In report, we assessed patients (n = 22) with obstructive cholestasis caused gallstone blockage ducts noncholestatic patient controls...
Idiopathic pulmonary fibrosis (IPF) is characterized by excessive deposition of extracellular matrix in the lung with fibroblast-to-myofibroblast transition, leading to chronically compromising function and death. However, very little known about metabolic alterations fibroblasts IPF, there still a lack pharmaceutical agents target dysregulation. Here we show glycolysis upregulation fatty acid oxidation (FAO) downregulation from fibrotic lung, perturbation FAO affects transdifferentiation....
Nonalcoholic fatty liver disease (NAFLD) has become a common health care burden worldwide. The high heterogeneity of NAFLD remains elusive and impairs outcomes clinical diagnosis pharmacotherapy. Several classifications have been proposed on the basis clinical, genetic, alcoholic, or serum metabolic analyses. Yet, accurately predicting progression to cirrhosis hepatocellular carcinoma (HCC) in patients challenge. Here, Chinese cohort patients, we classified into three distinct molecular...
The present study aimed to determine the levels of cathepsin B (cath B), L L), cystatin C, urokinase plasminogen activator (u-PA) and receptor (u-PAR) in sera patients with lung cancer compared healthy controls using ELISA. Concomitantly, relationship between components clinicopathological prognosis was analyzed. included 30 volunteers 105 patients. Blood samples were collected cath B, L, u-PA u-PAR measurements made Results showed that significantly higher patient group controls....
The anticancer effects of artesunate (ART) have been well documented. However, its potential against skin cancer has not explored yet. Herein we reported that 60 μmol/l ART effectively inhibited A431 (human epidermoid carcinoma cells) growth but HaCaT (normal human keratinocyte cells). Our results revealed induced cell cycle arrest at G0/G1 phase through the downregulation cyclin A1, B, D1, Cdk2, Cdk4, and Cdk6. This correlated with upregulation p21 p27. 5-bromodeoxyuridine incorporation...
Abstract The endoplasmic reticulum (ER) stress signaling or unfolded protein response (UPR) is a common feature of many human diseases, including cancer. Excessive activation ER directly induces cell death, holding new promising strategy for the therapeutic intervention Current ER‐stress‐inducing agents mainly target UPR components proteasomes, which exert limited treatment efficacy and undesired side effects due to unselective poor tumor‐specific distribution. In this study, unique...
The human positive cofactor 4 (PC4) is initially identified as a transcriptional and has an important role in embryonic development malignant transformation. However, the clinical significance molecular mechanisms of PC4 breast cancer progression are still unknown. We investigated expression 114 cases primary matched normal tissue specimens, studied impact well this altered on growth metastasis both vitro vivo. was significantly upregulated high positively correlated with poor prognosis...
A near-infrared mitochondrial dye serves as novel oxidative phosphorylation inhibitor for acute myeloid leukemia–targeted imaging.
Abstract Although it is well known that the reduction of interstitial cells Cajal (ICCs) associated with several gastrointestinal motility disorders in clinic, unknown whether mature ICCs still have an active plasticity adult mammals. This study focused on issues during Imatinib administration and recovery following drug withdrawal small intestine guinea pigs. were revealed by immunofluorescence whole mount preparations anti‐Kit, α‐smooth muscle actin, (α‐SMA), 5‐bromo‐2′‐deoxyuridine (BrdU)...
There is an urgent but unmet need for mitigating radiation-induced intestinal toxicity while radio sensitising tumours abdominal radiotherapy. We aimed to investigate the effects of metformin on and radiosensitivity colorectal tumours.Acute chronic histological injuries intestine from mice were used assess radioprotection IEC-6 cell line was mechanisms in vitro. The fractionated radiation model HCT116 HT29 tumour grafts determine cancer.Metformin alleviated acute by optimising mitophagy...
Postpartum depression (PPD) profoundly impacts the mental and physical health of women globally is an incurable psychological disorder. Traditional pharmacological treatments often have strong side effects may adversely affect infant through breastfeeding, underscoring critical need for natural gentle treatment strategies. Sugemule-7, a traditional Chinese medicine comprising multiple plant ingredients, represents potentially safer more effective alternative. To investigate its preventive on...
BACKGROUND:Because of the insensitivity renal cell carcinoma (RCC) to both chemotherapy and radiotherapy, surgery remains primary approach for anticancer treatment. However, patients who do not receive timely diagnoses may be suitable surgery, especially in late phase tumor development. Thus, discovery novel effective treatment is great importance. Allyl isothiocyanate (AITC) can inhibit proliferation induce apoptosis many cancer cells. In this paper, we report on an vitro study determine...
Abstract Background Human positive cofactor 4 (PC4) was initially characterized as a multifunctional transcriptional cofactor, but its role in skin wound healing is still unclear. The purpose of this study to explore the PC4 through knock-in mouse model. Methods A model (PC4+/+) with dorsal full-thickness used investigate biological functions healing. Quantitative PCR, Western blot analysis and immunohistochemistry were performed evaluate expression PC4; Sirius red staining...
Abstract Research on ageing‐associated genes is important for investigating ageing and anti‐ageing strategies. Here, we firstly reported that the human positive cofactor 4 (PC4), a multifunctional highly conserved nucleoprotein, accumulated activated during causes global accelerated process by disrupting proteostasis. Mechanistically, PC4 interacts with Sin3‐HDAC complex inhibits its deacetylated activity, leads to hyper‐acetylation of histones at promoters mTOR‐related mTOR signalling...
Several studies have shown that curcumin can induce apoptosis and inhibit growth in human A549 lung adenocarcinoma cells. However, the mechanism is not completely understood yet. In present study, we investigated vitro effect of on cell viability, disorganization actin cytoskeleton Our results showed significantly inhibited viability cells a dose- time-dependent manner by induced apoptosis. The apoptotic process was associated with architecture microfilaments decrease levels F-actin....