A5103117596- Tryptophan and brain disorders
- MicroRNA in disease regulation
- Neurogenesis and neuroplasticity mechanisms
- Autism Spectrum Disorder Research
- Extracellular vesicles in disease
- Nerve injury and regeneration
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Epigenetics and DNA Methylation
- Stress Responses and Cortisol
- Genetics and Neurodevelopmental Disorders
- Acute Ischemic Stroke Management
- Cancer-related molecular mechanisms research
- Plant Pathogens and Fungal Diseases
- Down syndrome and intellectual disability research
- RNA modifications and cancer
- Mesenchymal stem cell research
- Maternal Mental Health During Pregnancy and Postpartum
- Heat shock proteins research
- Traumatic Brain Injury and Neurovascular Disturbances
- Circular RNAs in diseases
- Genomics and Rare Diseases
- Neurological Disease Mechanisms and Treatments
- Child Nutrition and Feeding Issues
- Nuclear Receptors and Signaling
Minzu University of China
2011-2025
Henan Psychiatric Hospital
2024-2025
Xinxiang Medical University
2024-2025
Chengdu Medical College
2024
Chengdu Second People's Hospital
2024
Valley City State University
2020-2023
Software (Spain)
2023
Suizhou Central Hospital
2019-2022
Central South University
2014-2021
Massachusetts General Hospital
2015-2021
Background: Neurotrophic Factor-α1/Carboxypeptidase E (NF-α1/CPE) is a pivotal neuroprotective protein implicated in rescuing cognitive decline associated with Alzheimer's disease (AD). However, its direct role AD pathogenesis remains unexplored. Methods: We utilized the Cre/LoxP system to diminish NF-α1/CPE expression, and employed AAV-mediated overexpression of NF-α1/CPE. Results: expression was significantly down-regulated advanced stages age 5xFAD mice. Reduced levels hippocampus mice...
Genetic variants conferring risk for schizophrenia (SCZ) have been extensively studied, but the role of posttranscriptional mechanisms in SCZ is not well studied. Here we performed first genome-wide microRNA (miRNA) expression profiling serum-derived exosome from 49 first-episode, drug-free patients and 46 controls identified miRNAs co-regulated modules that were perturbed SCZ. Putative targets these SCZ-affected enriched strongly genes implicated protein glycosylation also related to...
Insomnia, characterized by difficulty in initiating and sustaining sleep or waking prematurely without the ability to return sleep, affects approximately 30% of population. The underlying mechanisms insomnia remain unclear objective diagnosic measures are scarce. It is an opportunity explore roles peripheral blood exosomal miRNAs patients. Methods: Exosomal were isolated from 20 patients equal number healthy individuals. A comprehensive genome-wide miRNA expression analysis was conducted...
Abstract Exosomes have been suggested as promising targets for the diagnosis and treatment of neurological diseases, including schizophrenia (SCZ), but potential role exosome-derived metabolites in these diseases was rarely studied. Using ultra-performance liquid chromatography-tandem mass spectrometry, we performed first metabolomic study serum-derived exosomes from patients with SCZ. Our sample comprised 385 332 healthy controls recruited 3 clinical centers 4 independent cohorts. We...
Exosomes are involved in the pathophysiology of neuropsychiatric diseases, but role exosomes schizophrenia (SCZ) is unclear. Here, we demonstrate that transplantation serum from SCZ patients into mice caused behavioral abnormalities such as deficits prepulse inhibition and sociability, hyperactivity, anxiogenesis. A comparative bioinformatics analysis suggested shared distinct differentially expressed genes (DEGs) enriched molecular pathways brains exosome-recipient mice, methylazoxymethanol...
Background. Exosomes are extracellular vesicles that play important roles in various physiological and pathological functions. Previous studies have demonstrated exosome-derived contents promising biomarkers to inform the pathogenesis diagnosis of major depressive disorder schizophrenia. Methods. We used ultraperformance liquid chromatography-tandem mass spectrometry analyze differentially expressed metabolites serum exosomes patients with bipolar (BD) evaluated potential exosomal as for BD....
Abstract Background and Hypothesis Schizophrenia (SCZ) is a multifaceted mental disorder marked by spectrum of symptoms, including hallucinations, delusions, cognitive deficits, negative symptoms. Its etiology involves intricate interactions between genetic environmental factors, posing significant challenges for effective treatment. We hypothesized that intranasal administration exosomes derived from nasal olfactory mucosal mesenchymal stem cells (OM-MSCs-exos) could alleviate SCZ-like...
Brain-derived neurotrophic factor (BDNF), via activation of TrkB receptors, mediates vital physiological functions in the brain, ranging from neuronal survival to synaptic plasticity, and has been implicated pathophysiology neurodegenerative disorders. Although transcriptional regulation BDNF gene ( Bdnf ) extensively studied, much remains be understood. We discovered a sequence within promoter 4 that binds basic helix-loop-helix protein BHLHB2 is target for BHLHB2-mediated repression. NMDA...
Mice and rats are the most commonly used animals for preclinical stroke studies, but it is unclear whether targets mechanisms always same across different species. Here, we mapped baseline expression of a chemokine/cytokine subnetwork compared responses after oxygen–glucose deprivation in primary neurons, astrocytes, microglia from mouse, rat, human. Baseline profiles chemokines (CX3CL1, CXCL12, CCL2, CCL3, CXCL10) cytokines (IL-1α, IL-1β, IL-6, IL-10, TNFα) showed significant differences...
The association between Down syndrome and celiac disease has been reported by many studies. However, the prevalence of (CD) in (DS) varies considerably across studies (from 0 % to 19 %). aim this study was use meta-analysis exam CD patients with DS.A systematic search English articles from Pubmed, Web Science CNKI without year limitation. Data were extracted two independent observers pooled using a random effects model Comprehensive Meta-Analysis Version 2 software.A analysis, based on 31...
Magnetic poly (D,L-lactide-co-glycolide) (PLGA)/lipid nanoparticles (MPLs) were fabricated from PLGA, L-α-phosphatidylethanolamine (DOPE), 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-amino (polyethylene glycol) (DSPE-PEG-NH2), and magnetic (NPs), then conjugated to trans-activating transcriptor (TAT) peptide. The TAT-MPLs designed target the brain by guidance TAT conjugation. drugs hesperidin (HES), naringin (NAR), glutathione (GSH) encapsulated in MPLs with drug loading capacity...