A5041731322- Acute Ischemic Stroke Management
- Cerebral Venous Sinus Thrombosis
- Cerebrovascular and Carotid Artery Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Venous Thromboembolism Diagnosis and Management
- Cardiac Ischemia and Reperfusion
- Intracerebral and Subarachnoid Hemorrhage Research
- Anesthesia and Neurotoxicity Research
- Stroke Rehabilitation and Recovery
- Thermal Regulation in Medicine
- Intracranial Aneurysms: Treatment and Complications
- Vascular Malformations Diagnosis and Treatment
- Neurological Disorders and Treatments
- Cardiac Arrest and Resuscitation
- MicroRNA in disease regulation
- Mitochondrial Function and Pathology
- Blood Coagulation and Thrombosis Mechanisms
- Barrier Structure and Function Studies
- Neurosurgical Procedures and Complications
- Neuroscience and Neuropharmacology Research
- High Altitude and Hypoxia
- Neurological Complications and Syndromes
- Neonatal and fetal brain pathology
Capital Medical University
2016-2025
Chinese Institute for Brain Research
2016-2025
Tongji University
2024-2025
Beijing Xuanwu Traditional Chinese Medicine Hospital
2013-2025
National Health and Family Planning Commission
2022-2025
Beihang University
2019-2025
First Affiliated Hospital of Jiangxi Medical College
2025
Nanchang University
2023-2025
Beijing Ditan Hospital
2025
Sun Yat-sen University
2025
The effects and risks of endovascular thrombectomy 6 to 24 hours after stroke onset due basilar-artery occlusion have not been extensively studied.
Background and Purpose— Interleukin-4 (IL-4) is a unique cytokine that may contribute to brain repair by regulating microglia/macrophage functions. Thus, we examined the effect of IL-4 on long-term recovery polarization in 2 well-established stroke models. Methods— Transient middle cerebral artery occlusion or permanent distal was induced wild-type knockout C57/BL6 mice. In separate cohort animals, (60 ng/d for 7 days) vehicle infused into cerebroventricle after transient occlusion....
Abstract The mechanism and long-term consequences of early blood–brain barrier (BBB) disruption after cerebral ischaemic/reperfusion (I/R) injury are poorly understood. Here we discover that I/R induces subtle BBB leakage within 30–60 min, likely independent gelatinase B/MMP-9 activities. is caused by the activation ROCK/MLC signalling, persistent actin polymerization disassembly junctional proteins microvascular endothelial cells (ECs). Furthermore, EC alterations facilitate subsequent...
This study aims to evaluate protective effects of brief repetitive bilateral arm ischemic preconditioning (BAIPC) on stroke recurrence in patients with symptomatic atherosclerotic intracranial arterial stenosis (IAS).A total 68 consecutive cases IAS, diagnosed by imaging, were enrolled this prospective and randomized study. All received standard medical management. Patients the BAIPC group (n = 38) underwent 5 cycles consisting upper limb ischemia followed reperfusion. The procedure was...
Background As a leading cause of severe disability and death, stroke places an enormous burden on the health care system in China. There are limited data pattern current medical practice quality delivery for patients at national level. Aim The nation-wide prospective registry, China National Stroke Registry, will be considered with regard to its design, progress, geographic coverage, hospital patient characteristics. Methods Between September 2007 August 2008, Registry recruited consecutive...
Parkinson's disease (PD) is a common neurodegenerative that lacks therapies to prevent progressive neurodegeneration. Impaired energy metabolism and reduced ATP levels are features of PD. Previous studies revealed terazosin (TZ) enhances the activity phosphoglycerate kinase 1 (PGK1), thereby stimulating glycolysis increasing cellular levels. Therefore, we asked whether enhancement PGK1 would change course In toxin-induced genetic PD models in mice, rats, flies, induced pluripotent stem...
Due to the aging of global population and derivative increase in aging-related non-communicable diseases their economic burden, there is an urgent need promote research on as a way improve healthy productive longevity for elderly population. To accomplish this goal, we advocate following policies: 1) Increasing funding development specifically directed ameliorate degenerative processes extend lifespan population; 2) Providing set incentives commercial, academic, public governmental...
To date, only uncontrolled studies have evaluated the efficacy and safety of endovascular treatment (EVT) in patients with cerebral venous thrombosis (CVT), leading to lack recommendations on EVT for CVT.To evaluate a severe form CVT.TO-ACT (Thrombolysis or Anticoagulation Cerebral Venous Thrombosis) was multicenter, open-label, blinded end point, randomized clinical trial conducted 8 hospitals 3 countries (the Netherlands, China, Portugal). Patients were recruited from September 2011...
In China, stroke is a major cause of mortality, and long-term physical cognitive impairment. To meet this challenge, the Ministry Health China Stroke Prevention Project Committee (CSPPC) was established in April 2011. This committee actively promotes prevention control China. With government financial support 838.4 million CNY, 8.352 people from 536 screening points 31 provinces have received follow-up over last seven years (2012–2018). 2016, CSPPC issued plan to establish centers. shorten...
Evidence supports using antiplatelet therapy in patients with acute ischemic stroke. However, neurological deterioration remains common under the currently recommended regimen, leading to poor clinical outcomes.
We observed that microRNA-424 (miR-424) significantly decreased in an miRNA profile of circulating lymphocytes patients with ischemic stroke. The present study focused on the potential and mechanism miR-424 protecting brain injury mice. Cerebral ischemia was induced by middle cerebral artery occlusion C57/BL6 infarction volume, neuronal apoptosis, microglia activation were determined 2,3,5-triphenyltetrazolium chloride staining, immunofluorescence, Western blot. BV2 microglial cell activity,...
We previously showed that the microRNA miR-424 protects against permanent cerebral ischemic injury in mice by suppressing microglia activation. This study investigated role of transient ischemia with a focus on oxidative stress-induced neuronal injury.Transient was induced C57/BL6 middle artery occlusion for 1 hour followed reperfusion (ischemia/reperfusion). The level peri-infarct cortex quantified. Mice were also administered angomir intracerebroventricular injection. Cerebral infarct...
Stroke is the most common type of cerebrovascular disease and a leading cause disability death. Ischemic stroke accounts for approximately 80% all strokes. The remaining 20% strokes are hemorrhagic in nature. To date, therapeutic options acute ischemic very limited. Recent research suggests that shifting microglial phenotype from pro-inflammatory M1 state toward anti-inflammatory tissue-reparative M2 may be an effective strategy stroke. dietary phytochemical curcumin has shown promise...
Following stroke, microglia can be driven to the "classically activated" pro-inflammatory (M1) phenotype and "alternatively anti-inflammatory (M2) phenotype. Salidroside (SLDS) is known inhibit inflammation possess protective effects in neurological diseases, but date, exact mechanisms involved these processes after stroke have yet elucidated. The purpose of this study was determine SLDS on neuroprotection microglial polarization stroke.Male adult C57/BL6 mice were subjected focal transient...