A5100326428- Glioma Diagnosis and Treatment
- MicroRNA in disease regulation
- Immune cells in cancer
- Epigenetics and DNA Methylation
- Phagocytosis and Immune Regulation
- Circular RNAs in diseases
- Cancer, Hypoxia, and Metabolism
- CRISPR and Genetic Engineering
- Vascular Malformations Diagnosis and Treatment
- Cerebral Venous Sinus Thrombosis
- RNA Research and Splicing
- Protein Degradation and Inhibitors
- Cancer Immunotherapy and Biomarkers
- Neurogenesis and neuroplasticity mechanisms
- RNA modifications and cancer
- Asymmetric Synthesis and Catalysis
- Ubiquitin and proteasome pathways
- Cell Adhesion Molecules Research
- Acute Myeloid Leukemia Research
- Ferroptosis and cancer prognosis
- Histone Deacetylase Inhibitors Research
- Insect Resistance and Genetics
- Acute Ischemic Stroke Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Cancer Cells and Metastasis
Chinese Institute for Brain Research
2020-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2007-2025
Soochow University
2015-2025
Zhejiang University
2023-2025
Second Affiliated Hospital of Zhejiang University
2018-2025
Fudan University
2017-2025
Zhejiang Cancer Hospital
2025
Huashan Hospital
2017-2025
China Rehabilitation Research Center
2022-2025
Yinchuan First People's Hospital
2025
Severe acute respiratory syndrome coronavirus (SARS-CoV) is the pathogen of SARS, which caused a global panic in 2003. We describe here screening Chinese herbal medicine-based, novel small molecules that bind avidly with surface spike protein SARS-CoV and thus can interfere entry virus to its host cells. achieved this by using two-step method consisting frontal affinity chromatography-mass spectrometry coupled viral infection assay based on human immunodeficiency (HIV)-luc/SARS pseudotyped...
The Arabidopsis gene AVP1 encodes a vacuolar pyrophosphatase that functions as proton pump on the membrane. Overexpression of in Arabidopsis, tomato and rice enhances plant performance under salt drought stress conditions, because up-regulation type I H+-PPase from may result higher electrochemical gradient, which facilitates enhanced sequestering ions sugars into vacuole, reducing water potential resulting increased drought- tolerance when compared to wild-type plants. Furthermore,...
Tissue inhibitor matrix metalloproteinase 1 (TIMP1) plays a vital role in carcinogenesis, yet its precise functional roles and regulation remain unclear. In this study, we aim to investigate biological function clinical significance human colon cancer. We analyzed the expression of TIMP1 both public database (Oncomine TCGA) 94 cases primary cancer matched normal tissue specimens. The underlying mechanisms altered on cell tumorigenesis, proliferation, metastasis were explored vitro vivo. was...
Currently, there is a huge demand to develop chemoimmunotherapy with reduced systemic toxicity and potent efficacy combat late-stage cancers spreading metastases. Here, we report several "cocktail" therapeutic formulations by mixing immunogenic cell death (ICD)-inducing chemotherapeutics immune adjuvants together alginate (ALG) for localized chemoimmunotherapy. Immune checkpoint blockade (ICB) antibody may be either included into this cocktail local injection or used via conventional...
To date, only uncontrolled studies have evaluated the efficacy and safety of endovascular treatment (EVT) in patients with cerebral venous thrombosis (CVT), leading to lack recommendations on EVT for CVT.To evaluate a severe form CVT.TO-ACT (Thrombolysis or Anticoagulation Cerebral Venous Thrombosis) was multicenter, open-label, blinded end point, randomized clinical trial conducted 8 hospitals 3 countries (the Netherlands, China, Portugal). Patients were recruited from September 2011...
Abstract Hydrophobic tagging (HyT) is a potential therapeutic strategy for targeted protein degradation (TPD). Norbornene was discovered as an unprecedented hydrophobic tag in this study and used to degrade the anaplastic lymphoma kinase (ALK) fusion by linking it ALK inhibitors. The most promising degrader, Hyt‐9 , potently reduced levels through Hsp70 ubiquitin−proteasome system (UPS) vitro without compensatory upregulation of . Furthermore, exhibited significant tumor‐inhibiting effect...
Abstract We previously reported that central nervous system (CNS) inactivation of Nf1 and p53 tumor suppressor genes in mice results the development low-grade to high-grade progressive astrocytomas. When tumors achieve high grade, they are frequently accompanied by Akt activation, reminiscent frequent association PTEN mutations human glioma. In present study, we introduced CNS heterozygosity Pten into Nf1/p53 astrocytoma model. Resulting had accelerated morbidity, shortened survival, full...
Significant spontaneous recovery occurs after essentially all forms of serious brain injury, although the mechanisms underlying this are unknown. Given that many injury such as traumatic (TBI) induce hippocampal neurogenesis, we investigated whether these newly generated neurons might play a role in recovery. By modeling TBI transgenic mice, determined injury-induced persisted over time and elaborated extensive dendritic trees stably incorporated themselves throughout neuronal layers dentate...
Gliomas are the most malignant and aggressive primary brain tumor in adults. Despite concerted efforts to improve therapies, their prognosis remains very poor. Isocitrate dehydrogenase 1 (IDH1) mutations have been discovered frequently glioma patients strongly correlated with improved survival. However, effect of IDH1 on chemosensitivity gliomas unclear. In this study, we generated clonal U87 U251 cell lines overexpressing R132H mutant protein (IDH1-R132H). Compared control cells IDH wild...
Abstract IgA nephropathy (IgAN) is one of the most common primary glomerulonephritis. Previously identified genome-wide association study (GWAS) loci explain only a fraction disease risk. To identify novel susceptibility in Han Chinese, we conduct four-stage GWAS comprising 8,313 cases and 19,680 controls. Here, show associations at ST6GAL1 on 3q27.3 (rs7634389, odds ratio (OR)=1.13, P =7.27 × 10 −10 ), ACCS 11p11.2 (rs2074038, OR=1.14, =3.93 −9 ) ODF1-KLF10 8q22.3 (rs2033562, OR=1.13, =1.41...
We are using induced pluripotent stem cell (iPSC) technology to study neuropsychiatric disorders associated with 22q11.2 microdeletions (del), the most common known schizophrenia (SZ)-associated genetic factor. Several genes in region have been implicated; a promising candidate is DGCR8, which codes for protein involved microRNA (miRNA) biogenesis. carried out miRNA expression profiling (miRNA-seq) on neurons generated from iPSCs derived controls and SZ patients del. Using thresholds of...
Immunotherapy with toll like receptor 9 (TLR9) agonist CpG ODN offers an emergent strategy to treat life-threatening malignant glioma. is typically applied invasively by intracranial and intrathecal administration which induces not only poor compliance lessened potency but also possibly strong adverse effects immunotoxicity. Here, it reported that immunotherapy of murine LCPN glioma greatly boosted polymersome-steered intravenous intranasal brain delivery CpG. efficiently loaded in...
Abstract Tumor-associated macrophages (TAM) play a crucial role in immunosuppression. However, how TAMs are transformed into immunosuppressive phenotypes and influence the tumor microenvironment (TME) is not fully understood. Here, we utilized single-cell RNA sequencing whole-exome data of glioblastoma (GBM) tissues identified subset dually expressing macrophage signatures, which were termed double-positive TAMs. Double-positive tended to be bone marrow–derived (BMDM) characterized by...