A5100356986- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- RNA modifications and cancer
- SARS-CoV-2 detection and testing
- Microbial Community Ecology and Physiology
- Sperm and Testicular Function
- Erythrocyte Function and Pathophysiology
- Protist diversity and phylogeny
- Animal Virus Infections Studies
- Liver Disease Diagnosis and Treatment
- Epigenetics and DNA Methylation
- RNA Interference and Gene Delivery
- Reproductive Biology and Fertility
- Immunotherapy and Immune Responses
- Cancer-related molecular mechanisms research
- Atmospheric chemistry and aerosols
- Immune cells in cancer
- MicroRNA in disease regulation
- Advanced biosensing and bioanalysis techniques
- RNA Research and Splicing
- Marine and coastal ecosystems
- Adipokines, Inflammation, and Metabolic Diseases
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Air Quality and Health Impacts
- Cancer-related gene regulation
Sichuan Cancer Hospital
2024-2025
University of Electronic Science and Technology of China
2024-2025
Guangdong Provincial Center for Disease Control and Prevention
2016-2025
Xi'an Jiaotong University
2020-2025
Huazhong University of Science and Technology
2020-2025
Zhengzhou University
2018-2025
Zhujiang Hospital
2020-2025
Guangxi Maternal and Child Health Hospital
2025
Southern Medical University
2019-2025
Beijing Anzhen Hospital
2025
Abstract The SARS-CoV-2 Delta variant has spread rapidly worldwide. To provide data on its virological profile, we here report the first local transmission of in mainland China. All 167 infections could be traced back to index case. Daily sequential PCR testing quarantined individuals indicated that viral loads infections, when they become PCR-positive, were average ~1000 times greater compared lineage A/B during epidemic wave China early 2020, suggesting potentially faster replication and...
Through the analysis of hundreds full-length cDNAs from fifteen species representing all major orders dinoflagellates, we demonstrate that nuclear-encoded mRNAs in species, ancestral to derived lineages, are trans-spliced with addition 22-nt conserved spliced leader (SL), DCCGUAGCCAUUUUGGCUCAAG (D = U, A, or G), 5' end. SL trans-splicing has been documented a limited but diverse number eukaryotes, which this process makes it possible translate polycistronically transcribed nuclear genes. In...
Significance Plant bioengineering will be necessary to sustain plant biology and agriculture, where the delivery of biomolecules such as DNA, RNA, or proteins cells is at crux biotechnology. Here, we show that DNA nanostructures can internalize into deliver siRNA mature tissues without external aid. Furthermore, demonstrate nanostructure size, shape, compactness, stiffness affect both internalization subsequent gene silencing efficiency. Interestingly, also find attachment locus affects...
Summary We report the first local transmission of SARS-CoV-2 Delta variant in mainland China. All 167 infections could be traced back to index case. Daily sequential PCR testing quarantined subjects indicated that viral loads infections, when they become PCR+, were on average ∼1000 times greater compared A/B lineage during initial epidemic wave China early 2020, suggesting potentially faster replication and infectiousness infection. performed high-quality sequencing samples from 126...
Posttranscriptional gene silencing (PTGS) is a powerful tool to understand and control plant metabolic pathways, which central biotechnology. PTGS commonly accomplished through delivery of small interfering RNA (siRNA) into cells. Standard siRNA methods (Agrobacterium viruses) involve coding DNA vectors are only tractable for certain species. Here, we develop nanotube-based platform direct show high efficiency in intact We demonstrate that nanotubes successfully deliver silence endogenous...
The development of neutralizing antibodies (NAbs) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) following infection or vaccination is likely to be critical for the sufficient population immunity drive cessation disease 2019 (COVID-19) pandemic. A large number serologic tests, platforms, and methodologies are being employed determine seroprevalence in populations select convalescent plasma samples therapeutic trials guide policies about reopening. However, tests have...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel first identified in December 2019. Notable features that make SARS-CoV-2 distinct from most other previously betacoronaviruses include receptor binding domain and unique insertion of 12 nucleotides or 4 amino acids (PRRA) at the S1/S2 boundary. In this study, we two deletion variants either directly affect polybasic cleavage site itself (NSPRRAR) flanking sequence (QTQTN). These deletions were verified by multiple...
Due to the adverse effects of erythropoietin (EPO) on cancer patient survival, it is necessary develop new agents that can be used efficiently manage and treat cancer-related anemia. In this study, novel distinctive carbon dots, J-CDs, derived from jujube are designed, synthesized, characterized. Based obtained results, material comprises sp2 sp3 atoms, as well oxygen/nitrogen-based groups, specifically promotes proliferation erythroid cells by stimulating self-renewal progenitor in vitro...
Atomically precise Cu clusters are highly desirable as catalysts for CO2 reduction reaction (CO2 RR), and they provide an appropriate model platform elaborating their structure-activity relationship. However, efficient overall photocatalytic RR with H2 O using assembled Cu-cluster aggregates single component photocatalyst has not been reported. Herein, we report a stable crystalline Cu-S-N cluster local protonated N-H groups (denoted Cu6 -NH). The catalyst exhibits suitable redox potentials,...
Abstract Targeting ferroptosis, an iron-dependent form of regulated cell death triggered by the lethal overload lipid peroxides, in cancer therapy is impeded our limited understanding intersection tumour’s metabolic feature and ferroptosis vulnerability. In present study, arginine identified as a ferroptotic promoter using metabolites library. This effect mainly achieved through arginine’s conversion to polyamines, which exerts their potent ferroptosis-promoting property H 2 O -dependent...
Bone marrow-derived mesenchymal stem cell-derived extracellular vesicles (BMSC-EVs) are widely used for therapeutic purposes in preclinical studies. However, their utility treating diabetes-associated atherosclerosis remains largely unexplored. Here, we aimed to characterize BMSC-EV-mediated regulation of autophagy and macrophage polarization. EVs were isolated from the supernatant cultured BMSCs characterized with transmission electron microscopy (TEM), nanoparticle tracking analysis (NTA),...
Orthotopic liver transplantation is the only effective treatment for failure but limited with shortage of available donor organs. Recent studies show promising results mesenchymal stem cells (MSCs)-based therapies. We systematically investigate therapeutic effects MSCs or MSC-conditioned medium (MSC-CM) in ameliorating fulminant hepatic (FHF) and chronic fibrosis mice. In addition, extensive flow cytometry analysis spleens from vehicle MSC- MSC-CM-treated mice was applied to reveal...
Mesenchymal stem cells (MSCs)-derived exosomes exhibit protective effects on damaged or diseased tissues. Hypoxia-inducible factor 1α (HIF-1α) plays a critical role in bone development. However, HIF-1α is easily biodegradable under normoxic conditions. The bone-marrow-derived mesenchymal (BMSCs) were transfected with adenovirus carrying triple point-mutations (amino acids 402, 564, and 803) the coding sequence (CDS). mutant can efficiently express functional proteins To date, no study has...
Stress granules (SGs) are discrete assemblies of stalled messenger ribonucleoprotein complexes (mRNPs) that form when eukaryotic cells encounter environmental stress. RNA-binding proteins (RBPs) mediate their condensation by recruiting populations mRNPs. However, the cellular and molecular mechanisms underlying role ubiquitin-associated protein 2-like (UBAP2L) in regulation SG dynamics remain elusive. Here, we show UBAP2L is required for both assembly disassembly. overexpression nucleated...
Abstract We report the first local transmission of SARS-CoV-2 Delta variant in mainland China. All 167 infections could be traced back to index case. Daily sequential PCR testing quarantined subjects indicated that viral loads infections, when they become PCR+, were on average ~1000 times greater compared A/B lineage during initial epidemic wave China early 2020, suggesting potentially faster replication and infectiousness infection. performed high-quality sequencing samples from 126...
The outbreak of coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome 2 (SARS-CoV-2), has posed a serious threat to global public health. mechanism pathogenesis and the host immune response SARS-CoV-2 infection are largely unknown. In present study, we applied quantitative proteomic technology identify quantify ubiquitination changes that occur in both virus Vero E6 cells during infection. By applying label-free, liquid chromatography with tandem mass...
Given that the high incidences of fruit mildew especially for strawberry and cherry during storage, green, edible, antifungal package materials was greatly required to improve shelf-life. Herein, an active film encapsulating Zanthoxylum bungeanum essential oil (ZBEO, 10%) into polyvinyl alcohol/β-Cyclodextrin (PVA/β-CD, 6:1) nanofibers fabricated via electrospinning technology, based on specific process optimization. ZBEO/Film composing (∼185 nm average diameter) exhibited adequate...
Pancreatic ductal adenocarcinoma (PDAC) cells maintain a high level of autophagy, allowing them to thrive in an austere microenvironment. However, the processes through which autophagy promotes PDAC growth and survival are still not fully understood. Here, we show that inhibition alters mitochondrial function by losing succinate dehydrogenase complex iron sulfur subunit B expression limiting availability labile pool. uses homeostasis, while other tumor types assessed require...