A5100767359- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- SARS-CoV-2 detection and testing
- Long-Term Effects of COVID-19
- COVID-19 diagnosis using AI
- Acute Ischemic Stroke Management
- Adipokines, Inflammation, and Metabolic Diseases
- COVID-19 and healthcare impacts
- Viral Infections and Immunology Research
- Cerebrovascular and Carotid Artery Diseases
- interferon and immune responses
- CAR-T cell therapy research
- Biosensors and Analytical Detection
- Inflammasome and immune disorders
- Lipoproteins and Cardiovascular Health
- Metabolomics and Mass Spectrometry Studies
- Diabetes and associated disorders
- Urban Transport and Accessibility
- COVID-19 epidemiological studies
- Flood Risk Assessment and Management
- Nutrition and Health in Aging
- Thermal Regulation in Medicine
- Virus-based gene therapy research
- Monoclonal and Polyclonal Antibodies Research
- Sustainable Development and Environmental Policy
Guangzhou Medical University
2019-2024
Guangzhou Eighth People's Hospital
2019-2024
Chengdu University of Technology
2022-2024
Tianjin University of Traditional Chinese Medicine
2023
Nanfang Hospital
2020
Southern Medical University
2020
Because there is no reliable risk stratification tool for severe coronavirus disease 2019 (COVID-19) patients at admission, we aimed to construct an effective model early identification of cases high progression COVID-19.In this retrospective multicenter study, 372 hospitalized with nonsevere COVID-19 were followed > 15 days after admission. Patients who deteriorated or critical and those maintained a state assigned the groups, respectively. Based on baseline data 2 constructed prediction...
Abstract The SARS-CoV-2 Delta variant has spread rapidly worldwide. To provide data on its virological profile, we here report the first local transmission of in mainland China. All 167 infections could be traced back to index case. Daily sequential PCR testing quarantined individuals indicated that viral loads infections, when they become PCR-positive, were average ~1000 times greater compared lineage A/B during epidemic wave China early 2020, suggesting potentially faster replication and...
Coronavirus disease 2019 (COVID-19) is a respiratory disorder caused by the highly contagious severe acute syndrome coronavirus 2. The immunopathological characteristics of patients with COVID-19, either systemic or local, have not been thoroughly studied. In present study, we analysed both changes in number various immune cell types as well cytokines important for reactions and inflammation. Our data indicate that COVID-19 exhibited an overall decline lymphocytes including CD4+ CD8+ T...
BackgroundA novel variant of SARS-CoV-2, the Delta concern (VOC, also known as lineage B.1.617.2), is fast becoming dominant strain globally. We reported epidemiological, viral, and clinical characteristics hospitalized patients infected with VOC during local outbreak in Guangzhou, China.MethodsWe extracted epidemiological information pertaining to 159 cases across seven transmission generations between May 21 June 18, 2021. The whole chain was described. Kinetics viral load were compared a...
Abstract Background Due to no reliable risk stratification tool for severe corona virus disease 2019 (COVID-19) patients at admission, we aimed construct an effective model early identifying cases high of progression COVID-19. Methods In this retrospective three-centers study, 372 non-severe COVID-19 during hospitalization were followed more than 15 days after admission. Patients who deteriorated or critical and kept state assigned the group, respectively. Based on baseline data two groups,...
Summary Coronavirus disease 2019 (COVID-19) is a respiratory disorder caused by the highly contagious SARS-CoV-2. The immunopathological characteristics of COVID-19 patients, either systemic or local, have not been thoroughly studied. In present study, we analyzed both changes in cellularity various immune cell types as well cytokines important for reactions and inflammation. Our data indicate that patients with severe exhibited an overall decline lymphocytes including CD4+ CD8+ T cells, B...
Abstract Abnormal glucose and lipid metabolism in COVID-19 patients were recently reported with unclear mechanism. In this study, we retrospectively investigated a cohort of without pre-existing metabolic-related diseases, found new-onset insulin resistance, hyperglycemia, decreased HDL-C these patients. Mechanistically, SARS-CoV-2 infection increased the expression RE1-silencing transcription factor (REST), which modulated secreted metabolic factors including myeloperoxidase, apelin,...
Background: As a result of the growing prevalence plasmid-mediated mobile colistin resistance gene mcr-1 among Gram-negative bacteria, surveillance mc r- 1 has been globally applied. In our study, we aimed to shed light on possibility transmission -resistant isolates through market retail fruits. Methods and results: Herein, 133 different fruit surface samples were collected screened for MCR variants ( mcr-8 ) using PCR confirmed with sequencing. We identify first time -carrying Escherichia...
Abstract The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic of novel disease (COVID-19). neutralizing monoclonal antibodies (mAbs) targeting the receptor-binding domain (RBD) SARS-CoV-2 are among most promising strategies to prevent and treat COVID-19. However, variants concern (VOCs) profoundly reduced efficacies mAbs vaccines approved for clinical use. Herein, we demonstrated mAb 35B5 efficiently neutralizes both wild-type (WT) VOCs, including...
: Previous studies of coronavirus disease 2019 (COVID-19) were mainly focused on cross-sectional analysis. In this study, we sought to evaluate the dynamic changes immunological and radiographic features, association with outcome pulmonary lesions in COVID-19 patients.
To systematically explore potential biomarkers which can predict disease severity in COVID-19 patients and prevent the occurrence or development of severe COVID-19, levels 440 factors were analyzed categorized according to severity; including asymptomatic, mild, moderate, severe, convalescent healthy control groups. Factor candidates validated by ELISA functional relevance was uncovered bioinformatics analysis. identify patient sera from three different groups (moderate, critical) at time...
Coronavirus disease 2019 (COVID-19), caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has rapidly become a global pandemic.Most discharge criteria for patients COVID-19 recommend two consecutive negative reverse-transcriptase polymerase-chain reaction (RT-PCR) test results from specimens over 24-hour interval.2][3][4][5][6][7][8] Two cohort studies reported that 14.5% (38/262) and 16.7% (69/414) of retesting were positive SARS-CoV-2 RNA after discharge....
The existence of asymptomatic and re-detectable positive coronavirus disease 2019 (COVID-19) patients presents the control challenges COVID-19. Most studies on immune responses in COVID-19 have focused moderately or severely symptomatic patients; however, little is known about response (RP) patients. Here we performed a comprehensive analysis transcriptomic profiles peripheral blood mononuclear cells (PBMCs) from 48 which included 8 asymptomatic, 13 symptomatic, 15 recovered 12 RP weighted...
Background: In 2020， the current outbreak of Coronavirus Disease 2019(COVID-19) has constituted a global pandemic. But question about immune mechanism patients with COVID-19 is unclear and cause particular concern to world. Here, we launched follow-up analysis antibodies against SARS-CoV-2 192 patients, aiming depict kinetics profile explore related factors expression in patient. Methods: A total enrolled designated hospital Guangzhou , Eighth People's Hospital, from January February 2020...
The prevention of the COVID-19 pandemic is highly complicated by prevalence asymptomatic and recurrent infection. Many previous immunological studies have focused on symptomatic convalescent patients, while immune responses in patients re-detectable positive cases remain unclear. Here we comprehensively analyzed peripheral T-cell receptor (TCR) repertoire 54 different courses, including asymptomatic, symptomatic, convalescent, cases. We identified a set V-J gene combinations characterizing...
The kidney tropism of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has been well‐validated clinically and often leads to various forms renal damage in disease‐2019 (COVID‐19) patients. However, the underlying mechanisms diagnostic approaches remain be determined. We interrogated expression virus‐related host factors single‐cell RNA sequencing (scRNA‐seq) datasets normal human kidneys with pre‐existing diseases validated results urinary proteomics COVID‐19 patients healthy...
Abstract Background We launched a retrospective analysis of SARS-CoV-2 antibodies in 192 patients with COVID-19, aiming to depict the kinetic profile and explore factors related antibody expression. Methods Data on confirmed COVID-19 between January February 2020 was collected from designated hospital that received Guangzhou, China. Moreover, cohort 130 suspected 209 healthy people were also enrolled this study. IgM IgG detected by chemiluminescence immunoassay kits different groups. Results...
Low-density lipoprotein cholesterol (LDL-C) is a well-known risk factor for coronary heart disease but protects against infection and sepsis. We aimed to disclose the exact association between LDL-C severe 2019 novel coronavirus (COVID-19). Baseline data were retrospectively collected 601 non-severe COVID-19 patients from two centers in Guangzhou one center Shenzhen, on admission medically observed at least 15 days determine final outcome, including group ( n = 460) (severe critical cases)...
Background: Severe cases of coronavirus disease 2019 (COVID-19) rapidly develop acute respiratory distress leading to failure, with remarkably high short-term mortality rates. At present, there is no reliable risk stratification tool for COVID-19 patients. We aimed construct and validate a model early identification severe COVID-19.Methods: SARS-CoV-2 infected patients from two centers in Guangzhou one center Wuhan were included retrospectively, divided into the train external validation...
The effects of SARS-CoV-2 infection in the first trimester on pregnant woman and fetus remain unclear. We describe complete follow-up a with asymptomatic trimester. tested positive for viral RNA nasopharyngeal swabs her seventh week gestation was admitted to local hospital treatment. Although had BMI above 28 total gestational weight gain 21 kg, no pregnancy complications or severe related were reported. An ultrasound scan identified fetal abnormalities at 22 weeks. ended term (37 weeks),...