A5101779729- Fungal Infections and Studies
- HIV Research and Treatment
- Congenital Heart Disease Studies
- HIV/AIDS drug development and treatment
- Liver Disease Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Neonatal and fetal brain pathology
- Fetal and Pediatric Neurological Disorders
- Ovarian cancer diagnosis and treatment
- HIV/AIDS Research and Interventions
- Prenatal Screening and Diagnostics
- Antifungal resistance and susceptibility
- Congenital gastrointestinal and neural anomalies
- Infant Health and Development
- Ideological and Political Education
- Lipoproteins and Cardiovascular Health
- Hepatitis B Virus Studies
- SARS-CoV-2 and COVID-19 Research
- Sleep and Wakefulness Research
- Syphilis Diagnosis and Treatment
- Alcohol Consumption and Health Effects
- Tracheal and airway disorders
- Ovarian function and disorders
- COVID-19 and healthcare impacts
- Cytomegalovirus and herpesvirus research
Guangzhou Medical University
2020-2025
Guangzhou Eighth People's Hospital
2017-2025
Kunming Medical University
2025
Fujian Medical University
2009-2024
Second Affiliated Hospital of Fujian Medical University
2009-2024
Nanfang Hospital
2020
Southern Medical University
2020
Abstract The prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) is increasing globally, posing a major public health issue. This study analyzes the global, regional, and national burden MASLD its risk factors from 1990 to 2021, with projections 2030. We obtained data on prevalence, deaths, disability-adjusted life years (DALYs) Global Burden Disease 2021 for 204 countries. Counts rates per 100,000 population were calculated, trends 2030 predicted using Bayesian...
: Previous studies of coronavirus disease 2019 (COVID-19) were mainly focused on cross-sectional analysis. In this study, we sought to evaluate the dynamic changes immunological and radiographic features, association with outcome pulmonary lesions in COVID-19 patients.
To externally validate the Ovarian-adnexal Reporting and Data System (O-RADS) evaluate its performance in differentiating benign from malignant adnexal masses (AMs) compared with Gynecologic Imaging (GI-RADS) Assessment of Different NEoplasias adneXa (ADNEX).A retrospective analysis was performed on 734 cases Second Affiliated Hospital Fujian Medical University. All patients underwent transvaginal or transabdominal ultrasound examination. Pathological diagnoses were obtained for all included...
Background The development of human immunodeficiency virus (HIV) drug resistance significantly impairs patients’ quality life. However, the HIV-1 patterns in central nervous system (CNS) have been poorly studied. Objective We aimed to compare genotypes and mutations (DRMs) derived from cerebrospinal fluid (CSF) plasma antiretroviral therapy (ART)-naive or -experienced patients. Methods matched CSF samples 59 patients with HIV were subjected proteinase (PR), reverse transcriptase (RT),...
Transmitted drug resistance (TDR) that affects the effectiveness of first-line antiretroviral therapy (ART) regimen is becoming prevalent worldwide. However, its prevalence and transmission among HIV-1 treatment-naïve patients in Guangdong, China are rarely reported. We aimed to comprehensively analyze TDR clusters infected persons before ART Guangdong.The were recruited between January 2018 December 2018. The pol region was amplified by reverse transcriptional PCR sequenced sanger...
<i>Objective:</i> The aim of this study was to determine whether the type congenital heart disease (CHD) or function influence fetal cerebrovascular blood flow dynamics. <i>Methods:</i> Doppler velocimetry performed in umbilical artery (UA) and middle cerebral (MCA), ratio UA pulsatility index (PI) MCA PI (U/C PI) determined 45 fetuses with CHD at 20–40 weeks’ gestational age. control group consisted 275 healthy matched for Individual measurements were converted into...
Noninvasive evaluation of fetal lung development is a critical area study. Two-dimensional shear-wave elastography (2D-SWE) provides valuable insights into tissue stiffness, potentially correlating with different stages development. This study aims to explore the potential 2D-SWE technique for assessing maturity
Abstract Background We launched a retrospective analysis of SARS-CoV-2 antibodies in 192 patients with COVID-19, aiming to depict the kinetic profile and explore factors related antibody expression. Methods Data on confirmed COVID-19 between January February 2020 was collected from designated hospital that received Guangzhou, China. Moreover, cohort 130 suspected 209 healthy people were also enrolled this study. IgM IgG detected by chemiluminescence immunoassay kits different groups. Results...
This study aimed to evaluate the ultrasonographic pattern of cervical lymph nodes (CLNs) and whether levothyroxine with prednisone therapy is effective for lymphadenopathy in patients Hashimoto thyroiditis (HT).This retrospective was looking at confirmed diagnosis HT who underwent comprehensive neck ultrasound examination. We reviewed sonographic findings 127 HT, 234 euthyroid goiter, 122 healthy subjects. In addition, 30 untreated were recruited therapy. rescanned 9 months after treatment...
To investigate whether the ultrasound microcystic pattern (MCP) can accurately predict borderline ovarian tumors (BOTs).A retrospective collection of 393 patients who met inclusion criteria was used as study population. Indicators that could well identify BOT in different pathological types were derived by multivariate unordered logistic regression analysis. Finally, correlation between MCP and features analyzed.(1) present 55 tumors, including 34 BOTs (34/68, 50.0%), 16 malignant (16/88,...
Background Talaromycosis is one of the most common opportunistic infections in human immunodeficiency virus (HIV) infected patients. However, few researches have explored prevalence Southern China and fully assessed value Mp1p antigen screening for diagnosis talaromycosis. Methodology/Principal findings We performed a cross-sectional study HIV-infected antiretroviral therapy (ART)-naïve adult patients who were seen 2018 at Guangzhou Eighth People’s Hospital, Medical University. Serum samples...
Abstract Background This study aimed to develop a standardized expert consensus on anatomical examination of first-trimester fetal ultrasound. Methods Based the Delphi procedure, 122 experts from 27 grades medical institutions throughout China answered two-round questionnaire. Items for which 75% stated that they should be included were designated as recommended items; other items suggested items. Results Fetal ultrasound examinations in early pregnancy divided into basic (class I), detailed...
Objective To establish normative data for the fetal cisterna magna septa (CMS) at various gestational age,and to evaluate its clinical significance.Methods A total of consecutive between 14 and 40 week(GW) were included in this prospective study.The length width CMS measured by two-dimensional ultrasonography.Regression analysis was used study relationship age.Twenty-five case fetuses with absence 12 enlargement retrospectively analyzed past six years our hospital.Results ①The increased...
Objective To investigate the prevalence and characteristics of non-nucleoside reverse transcriptase inhibitors (NNRTIs) resistance-related gene mutations among AIDS patients with virological suppression failure in Guangdong Province 2015. Methods Plasma samples from receiving highly active antiretroviral therapy for more than one year viral loads > 1 000 copies/mL province (except Shenzhen)were collected January to December 2015. Total 612 HIV-1 fragments were amplified plasma using...
目的 探讨重组人干扰素α-1b联合小剂量西咪替丁治疗婴幼儿腹泻的临床疗效。 方法 将569例婴幼儿腹泻住院患儿根据入院单双日分成治疗组(n＝312)和对照组(n＝257)，治疗组在维持酸碱平衡、水电解质平衡基础上给予重组人干扰素α-1b(运德素)联合小剂量西咪替丁治疗，对照组在维持酸碱平衡、水电解质平衡基础上给予利巴韦林等其他辅助药物治疗，观察两组退热时间、腹泻缓解时间、住院天数、复发情况。 结果 治疗组退热时间、腹泻缓解时间、住院天数及停止治疗后1周内复诊例数分别为(1.2±0.2)d、(2.8±0.4)d、(4.3±1)d、3例，均显著优于对照组的(1.8±0.1)d、(4.0±0.4)d、(6.6±1)d、28例，两组差异均有统计学意义(t＝43.79、35.61、27.30，χ2＝26.99，均P<0.01)。 结论 重组人干扰素α-1b联合小剂量西咪替丁可有效治疗婴幼儿腹泻，效果显著优于常规治疗，治疗安全有效，不良反应少，值得临床推广。
Abstract Talaromycosis is a life-threatening fungal disease commonly seen in patients with acquired immunodeficiency syndrome (AIDS), which endemic Southern China and Southeast countries. The diagnostic methods available for talaromycosis are relatively time-consuming yield high mortality. Therefore, early diagnosis of extremely important. We aimed to determine potential method assisting its diagnosis. A total 283 AIDS admitted our hospital were prospectively included this cross-sectional...
Abstract Background Little is known about the ultrasonographic features of fetal isolated redundant foramen ovale flap (RFOF). Additionally, false positive diagnosis aortic coarctation (CoA) may be related to presence an RFOF. This study aimed explore RFOF and its differential with CoA. Methods was a retrospective cohort that included 54 fetuses: 15 RFOF, 9 CoA, 30 normal fetuses matched gestational age. The correlations diameter (FOFD)/left atrial (LAD) right (RAD)/LAD, ventricular...