A5067162914- Genetic Mapping and Diversity in Plants and Animals
- Genetics and Plant Breeding
- Genetic and phenotypic traits in livestock
- Ammonia Synthesis and Nitrogen Reduction
- Advanced Photocatalysis Techniques
- Tea Polyphenols and Effects
- Caching and Content Delivery
- SARS-CoV-2 and COVID-19 Research
- Plant Molecular Biology Research
- COVID-19 Clinical Research Studies
- Food Quality and Safety Studies
- Crop Yield and Soil Fertility
- Pregnancy and preeclampsia studies
- T-cell and B-cell Immunology
- Cytokine Signaling Pathways and Interactions
- Advanced battery technologies research
- Phytoestrogen effects and research
- Nanoparticle-Based Drug Delivery
- Acute Ischemic Stroke Management
- Photonic and Optical Devices
- Cerebrovascular and Carotid Artery Diseases
- Protein Hydrolysis and Bioactive Peptides
- Epigenetics and DNA Methylation
- Immune Cell Function and Interaction
- Advancements in Battery Materials
Fujian Medical University
2007-2025
Chongqing University of Science and Technology
2025
Chengdu University
2020-2025
Yunnan Agricultural University
2021-2025
Shandong University of Traditional Chinese Medicine
2023-2025
Second Affiliated Hospital of Fujian Medical University
2006-2025
Capital Medical University
2022-2025
Wenzhou Medical University
2009-2025
First Affiliated Hospital of Wenzhou Medical University
2014-2025
Sun Yat-sen University
2020-2024
The outbreak of coronavirus disease (COVID-19) caused by SARS-CoV-2 virus continually lead to worldwide human infections and deaths. Currently, there is no specific viral protein-targeted therapeutics. Viral nucleocapsid protein a potential antiviral drug target, serving multiple critical functions during the life cycle. However, structural information remains unclear. Herein, we have determined 2.7 Å crystal structure N-terminal RNA binding domain protein. Although overall similar as other...
Increased planting densities have boosted maize yields. Upright plant architecture facilitates dense planting. Here, we cloned UPA1 (Upright Plant Architecture1) and UPA2, two quantitative trait loci conferring upright architecture. UPA2 is controlled by a two-base sequence polymorphism regulating the expression of B3-domain transcription factor (ZmRAVL1) located 9.5 kilobases downstream. exhibits differential binding DRL1 (DROOPING LEAF1), physically interacts with LG1 (LIGULELESS1)...
Significance Flowering time is a critical determinant of crop adaptation to local environments. As result natural and artificial selection, maize has evolved reduced photoperiod sensitivity adapt regions over 90° latitude in the Americas. Here we show that distant Harbinger-like transposon acts as cis -regulatory element repress ZmCCT9 expression promote flowering under long days higher latitudes. The at another functional second flowering-time gene, ZmCCT10 , arose sequentially following...
Dysregulated immune cell responses have been linked to the severity of coronavirus disease 2019 (COVID-19), but specific viral factors severe acute respiratory syndrome 2 (SARS-CoV-2) were currently unknown. Herein, we reveal that Immunoglobulin-like fold ectodomain protein SARS-CoV-2 ORF7a interacts with high efficiency CD14+ monocytes in human peripheral blood, compared pathogenic SARS-CoV ORF7a. The crystal structure at 2.2 Å resolution reveals three remarkable changes on amphipathic side...
Maize (Zea mays) tassels underwent profound morphological changes during maize domestication and improvement. Although a number of genes affecting inflorescence development have been identified, the genetic basis in since is not well understood. Here, using large population 866 maize-teosinte BC2 S3 recombinant inbred lines genotyped 19 838 single nucleotide polymorphism (SNP) markers, we performed high-resolution quantitative trait locus (QTL) mapping for five tassel traits. We showed that...
Gene expression regulation plays an important role in controlling plant phenotypes and adaptation. Here, we report a comprehensive assessment of gene variation through the transcriptome analyses large maize-teosinte experimental population. Genome-wide mapping identified 25 660 quantitative trait loci (eQTL) for 17 311 genes, capturing unprecedented range variation. We found that local eQTL were more frequently mapped to adjacent displaying mode piggybacking, which consequently created...
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Abstract Although human antibodies elicited by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleocapsid (N) protein are profoundly boosted upon infection, little is known about function of N-reactive antibodies. Herein, we isolate and profile a panel 32 N protein-specific monoclonal (mAbs) from quick recovery disease-19 (COVID-19) convalescent patient who has dominant antibody responses to SARS-CoV-2 rather than spike (S) protein. The complex structure RNA binding domain...
Coronavirus disease 2019 (COVID-19) has caused massive disruptions to society and the economy, transcriptional regulatory mechanisms behind severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are poorly understood. Herein, we determined crystal structure of SARS-CoV-2 nucleocapsid protein C-terminal domain (CTD) at a resolution 2.0 Å, demonstrated that CTD comparable distinct electrostatic potential surface equivalent domains other reported CoVs, suggesting novel roles in viral RNA...
Monoclinic NiWO 4 nanoparticles with oxygen vacancies self-supported on nickel foam act as an efficient electrocatalyst for selective NO 2 − reduction to NH 3 , offering yield of ∼10 974.36 μg h −1 cm −2 and a faradaic efficiency ∼97.6%.
Hydrogen peroxide (H2O2) and ascorbic acid (AA), acting as two significant indicative species, correlate with the oxidative stress status in living brains, which have historically been considered to be involved mainly neurodegenerative disorders such Alzheimer's disease, Huntington's Parkinson's disease (PD). The development of efficient biosensors for simultaneous measurement their levels brains is vital understand roles played brain interactive relationship progress these diseases. Herein,...
Organic acids are one of important flavor and bioactive components in tea beverages, which changed significantly during the microbial fermentation pu-erh tea, but their metabolism is unclear. In this research, was industrially fermented, changes 74 including 26 organic were measured. After fermentation, contents 20 decreased [Variable importance projection (VIP) > 1.0; p < 0.05 Fold-change (FC) FC 0.67], Meanwhile, 13 compounds increased (VIP >1, 0.05, 1.5). These lead to a reddish-brown...
Ripened pu-erh tea derived from sun-dried green leaves of ancient plants (APRPT) is recognized for its premium quality and unique flavor profile, yet characteristic chemistry remains insufficiently elucidated. Here, five representative APRPTs were collected characterized by integrating flavoromics chemometric approaches. The exhibited a thick, reddish infusion color, mellow taste, strong, long-lasting mushroom aroma. Theabrownins, soluble sugars, caffeine, gallic acid identified as taste...
Summary The number of leaves and their distributions on plants are critical factors determining plant architecture in maize ( Zea mays ), leaf is frequently used as a measure flowering time, trait that key to local environmental adaptation. Here, using large set 866 maize‐teosinte BC 2 S 3 recombinant inbred lines genotyped by 19 838 single nucleotide polymorphism markers, we conducted comprehensive genetic dissection assess the its relationship time. We demonstrated two components total...
Ovarian follicle selection is an important process impacting the laying performance and fecundity of hens, regulated by follicle-stimulating hormone (FSH) through binding to its receptor (FSHR). In small yellow (6–8 mm in diameter) with highest expression FSHR will be recruited into preovulatory hierarchy during ovarian development.The study molecular mechanism chicken helpful for identification genes underlying egg traits other poultry species. Herein, transcriptomes follicles differing...
Alternative splicing (AS) enhances transcriptome diversity and plays important roles in regulating plant processes. Although widespread natural variation AS has been observed plants, how is regulated contribute to phenotypic poorly understood. Here, we report a population-level assembly genome-wide association study identify quantitative trait loci (sQTLs) developing maize (Zea mays) kernels from 368 inbred lines. We detected 19,554 unique sQTLs for 6570 genes. Most showed small isoform...
Abstract The outbreak of coronavirus disease (COVID-19) in China caused by SARS-CoV-2 virus continually lead to worldwide human infections and deaths. It is currently no specific viral protein targeted therapeutics yet. Viral nucleocapsid a potential antiviral drug target, serving multiple critical functions during the life cycle. However, structural information yet be clear. Herein, we have determined 2.7 Å crystal structure N-terminal RNA binding domain protein. Although overall similar...
Electrocatalytic reduction of nitrite (NO2-) to ammonia (NH3) can simultaneously achieve wastewater treatment and production, but it needs efficient catalysts. Herein, Cu2O particles self-supported on Cu foam with enriched oxygen vacancies are developed enable selective NO2- NH3, exhibiting a maximum NH3 yield rate 7510.73 μg h-1 cm-2 high faradaic efficiency 94.21% at -0.6 V in 0.1 M PBS containing NaNO2. Density functional theory calculations reveal the vital role during process, as well...