A5112469237- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Asthma and respiratory diseases
- Viral gastroenteritis research and epidemiology
- Complement system in diseases
- Allergic Rhinitis and Sensitization
- Pharmacological Effects of Natural Compounds
- Pharmaceutical and Antibiotic Environmental Impacts
- Computational Drug Discovery Methods
- SARS-CoV-2 detection and testing
- Handwritten Text Recognition Techniques
- Viral Infections and Immunology Research
- Tea Polyphenols and Effects
- Optical measurement and interference techniques
- Aquaculture Nutrition and Growth
- Adrenal and Paraganglionic Tumors
- Pulmonary Hypertension Research and Treatments
- IL-33, ST2, and ILC Pathways
- Reconstructive Facial Surgery Techniques
- Visual Attention and Saliency Detection
- ATP Synthase and ATPases Research
- Nasal Surgery and Airway Studies
- Immunotherapy and Immune Responses
- Cytomegalovirus and herpesvirus research
- Calcium signaling and nucleotide metabolism
Shanxi Academy of Medical Sciences
2021-2025
Shanxi Medical University
2021-2025
Tongji Hospital
2023-2025
Huazhong University of Science and Technology
2023-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Peking Union Medical College Hospital
2025
Tsinghua University
2025
Shanghai Ninth People's Hospital
2024
Shanghai Jiao Tong University
2024
Qingdao University of Science and Technology
2024
The outbreak of coronavirus disease (COVID-19) caused by SARS-CoV-2 virus continually lead to worldwide human infections and deaths. Currently, there is no specific viral protein-targeted therapeutics. Viral nucleocapsid protein a potential antiviral drug target, serving multiple critical functions during the life cycle. However, structural information remains unclear. Herein, we have determined 2.7 Å crystal structure N-terminal RNA binding domain protein. Although overall similar as other...
Dysregulated immune cell responses have been linked to the severity of coronavirus disease 2019 (COVID-19), but specific viral factors severe acute respiratory syndrome 2 (SARS-CoV-2) were currently unknown. Herein, we reveal that Immunoglobulin-like fold ectodomain protein SARS-CoV-2 ORF7a interacts with high efficiency CD14+ monocytes in human peripheral blood, compared pathogenic SARS-CoV ORF7a. The crystal structure at 2.2 Å resolution reveals three remarkable changes on amphipathic side...
Mitofusin-2 (MFN2) is a dynamin-like GTPase that plays central role in regulating mitochondrial fusion and cell metabolism. Mutations MFN2 cause the neurodegenerative disease Charcot-Marie-Tooth type 2A (CMT2A). The molecular basis underlying physiological pathological relevance of unclear. Here, we present crystal structures truncated human different nucleotide-loading states. Unlike other dynamin superfamily members including MFN1, forms sustained dimers even after GTP hydrolysis via...
Abstract Although human antibodies elicited by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleocapsid (N) protein are profoundly boosted upon infection, little is known about function of N-reactive antibodies. Herein, we isolate and profile a panel 32 N protein-specific monoclonal (mAbs) from quick recovery disease-19 (COVID-19) convalescent patient who has dominant antibody responses to SARS-CoV-2 rather than spike (S) protein. The complex structure RNA binding domain...
Coronavirus disease 2019 (COVID-19) has caused massive disruptions to society and the economy, transcriptional regulatory mechanisms behind severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are poorly understood. Herein, we determined crystal structure of SARS-CoV-2 nucleocapsid protein C-terminal domain (CTD) at a resolution 2.0 Å, demonstrated that CTD comparable distinct electrostatic potential surface equivalent domains other reported CoVs, suggesting novel roles in viral RNA...
Abstract The outbreak of coronavirus disease (COVID-19) in China caused by SARS-CoV-2 virus continually lead to worldwide human infections and deaths. It is currently no specific viral protein targeted therapeutics yet. Viral nucleocapsid a potential antiviral drug target, serving multiple critical functions during the life cycle. However, structural information yet be clear. Herein, we have determined 2.7 Å crystal structure N-terminal RNA binding domain protein. Although overall similar...
Cottonseed meal (CSM) is the major by-product of cottonseed oil extraction process with high protein content. However, presence free gossypol (FG) in CSM severely restricts its utilization food and animal feed industries. The development a biological strategy for effective removal FG has become an urgent need. In this study, three bacterial laccases including CotA from Bacillus licheniformis, CueO Escherichia coli, LcLac Loigolactobacillus coryniformis were heterologously expressed...
Scene text recognition has attracted particular research interest because it is a very challenging problem and various applications. The most cutting-edge methods are attentional encoder-decoder frameworks that learn the alignment between input image output sequences. In particular, decoder recurrently outputs predictions, using prediction of previous step as guidance for every time step. this study, we point out inappropriate use predictions in existing decoders restricts performance brings...
Von Hippel-Lindau (VHL) disease is an autosomal dominant disorder caused by germline pathogenic variants of the VHL gene, which can lead to abnormal growth blood vessels and cause development benign or malignant tumors, as well cysts in diverse organs. To date, no case reports have documented adrenocorticotropic hormone (ACTH)-secreting adenomas individuals with disease. We present a 19-year-old female individual who developed ACTH-secreting adenoma alongside hemangioblastomas central...
<title>Abstract</title> The reconstruction of textured 3D human models from a single image is fundamental task with wide-ranging applications in fields such as virtual reality, gaming, and digital rendering. Current approaches, however, are often time-consuming struggle to accurately capture detailed texture information, limiting their practicality real-time applications. To address this, we propose novel method, \textbf{Ultraman}, which significantly accelerates the process while enhancing...
Overuse of nitrogen fertilizer represents a considerable environmental problem globally, but especially in China. Recently, recent approach on an experimental scale based the diffusion so-called Three-Control Technology (TCT) successfully alleviated overuse southern China villages Guangdong Province, serving as reference point for other rice-producing countries tackling similar challenges. Here, we assessed correlation between rice yields and reduction use following introduction TCT. Our...
Abstract Epstein-Barr virus (EBV) is a γ-herpesvirus associated with the occurrence of several human malignancies. BBRF2 and BSRF1 are two EBV tegument proteins that have been suggested to form hetero-complex mediate viral envelopment, but molecular basis their interaction functional mechanism this complex remains unknown. Here, we present crystal structures alone in BSRF1. has compact globular architecture featuring central β-sheet surrounded by 10 helices, it represents novel fold distinct...
ORF8 is a viral immunoglobulin-like (Ig-like) domain protein encoded by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA genome. It tends to evolve rapidly and interfere with immune responses. However, structural characteristics of various proteins their subsequent effects on biological functions remain unclear. Herein, we determined crystal structures SARS-CoV-2 (S84) (one epidemic isoforms) bat RaTG13 variant at 1.62 Å 1.76 resolution, respectively. Comparison these...
Poria cocos is a traditional Chinese medicine (TCM) that can clear dampness, promote diuresis, and strengthen the spleen stomach. has been detected in many TCM compounds are used for COVID-19 intervention. However, active ingredients mechanisms associated with effect of on remain unclear. In this paper, cocos, along their potential targets related to COVID-19, were screened using TCMSP, GeneCards, other databases, by means network pharmacology. We then investigated components, targets,...
COVID-19 is a respiratory disease caused by severe acute syndrome coronavirus 2 (SARS-CoV-2). The pandemic has posed serious threat to global health and the economy, so it necessary find safe effective antibody drugs treatments.
CpG oligodeoxynucleotide (CpG-ODN; CpG, in short) has been employed as an adjuvant allergen specific immunotherapy (AIT) to treat allergic diseases. The underlying mechanism needs be further explained. aim of this study is examine the by which and dust mite extracts (DME, a antigen) alleviate experimental airway allergy. DME was used establish allergy mouse model. mice were directly exposed through nasal instillations (the CpG.DME therapy). response DCs responses airways assessed using...
Liupao tea, a drink homologous to medicine and food. It can treat dysentery, relieve heat, remove dampness, regulate the intestines stomach. The objective of this study is explore material basis mechanism tea intervention in COVID-19 provide new prevention treatment programme for COVID-19. We used high performance liquid chromatography analyze extract establish its fingerprint. main index components fingerprint were determined using SARS-COV-2 3-chymotrypsin-like protease (3CLpro), an vitro...
In this paper, we study the distributed optimisation problem in an iterative environment, where global objective function consists of agents' local functions, and each agent with performs repeated tasks finite time. The is to minimise by communication agents running system. To solve problem, propose a algorithm based on learning methods that combines terminal strategy subgradient strategy. When initial states all are same iteration, proposed algorithm, it proved asymptotically converge...
Abstract Objective To validate the feasibility of an innovative nasal lining‐framework complex (NLFC) for reconstructing total defects. Study Design Retrospective cohort study. Methods This NLFC is composed forearm flap and support framework. Twenty‐four patients were followed up a minimum 17 months in 5 centers. Patients' medical history data retrospectively analyzed. Visual Analog Scale (VAS) surgeons was used to evaluate aesthetic effects self‐satisfaction. The Nasal Obstruction Symptom...
Background: Many studies have demonstrated the efficacy of single-allergen sublingual immunotherapy (SLIT) in polysensitized patients with allergic rhinitis (AR), but less is reported asthma (AS). Method: Data 133 adult house dust mite (HDM)-induced AS who had been treated for 3 years were collected. These divided into control group (treated low to moderate dose inhaled glucocorticoids and long-acting β2 agonists, n = 37) SLIT (further Dermatophagoides farinae drops, 96). The contained three...