A5090688671- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA modifications and cancer
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- RNA Research and Splicing
- Cancer, Hypoxia, and Metabolism
- COVID-19 Clinical Research Studies
- Liver Disease Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- Epigenetics and DNA Methylation
- Innovative Educational Techniques
- Cancer, Lipids, and Metabolism
- Cancer-related gene regulation
- Hepatitis B Virus Studies
- COVID-19 diagnosis using AI
- Connective tissue disorders research
- Sepsis Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Endometriosis Research and Treatment
- Developmental Biology and Gene Regulation
- Hepatitis C virus research
- Inflammatory mediators and NSAID effects
- Gastric Cancer Management and Outcomes
- SARS-CoV-2 detection and testing
The First Hospital of Changsha
2025
Central South University
2017-2025
Qilu Hospital of Shandong University
2025
Chongqing Medical University
2021-2025
The Affiliated Yongchuan Hospital of Chongqing Medical University
2025
Third Affiliated Hospital of Sun Yat-sen University
2019-2024
Sun Yat-sen University
2019-2024
Tongji Hospital
2022-2023
Huazhong University of Science and Technology
2017-2023
Harbin Medical University
2015-2023
Because there is no reliable risk stratification tool for severe coronavirus disease 2019 (COVID-19) patients at admission, we aimed to construct an effective model early identification of cases high progression COVID-19.In this retrospective multicenter study, 372 hospitalized with nonsevere COVID-19 were followed > 15 days after admission. Patients who deteriorated or critical and those maintained a state assigned the groups, respectively. Based on baseline data 2 constructed prediction...
Abstract Background Due to no reliable risk stratification tool for severe corona virus disease 2019 (COVID-19) patients at admission, we aimed construct an effective model early identifying cases high of progression COVID-19. Methods In this retrospective three-centers study, 372 non-severe COVID-19 during hospitalization were followed more than 15 days after admission. Patients who deteriorated or critical and kept state assigned the group, respectively. Based on baseline data two groups,...
Abstract Background: Circular RNAs (circRNAs) are a class of non-coding (ncRNAs) broadly expressed in cells various species. However, the molecular mechanisms that link circRNAs with laryngeal squamous cell carcinoma (LSCC) not well understood. In present study, we attempted to provide novel basis for targeted therapy LSCC from aspect circRNA–microRNA (miRNA)–mRNA interaction. Methods: We investigated expression three paired tissues and adjacent non-tumor by microarray analysis....
Background: Activated hepatic stellate cells (aHSCs) regulate the function of immune during liver fibrosis. As major innate in liver, macrophages have inducible plasticity. Nevertheless, mechanisms through which aHSCs macrophages' phenotype and fibrosis cirrhosis remain unclear. In this study, we examined immunoregulatory explored their role regulating macrophage function. Methods: A total 96 patients with different stages chronic hepatitis B-related were recruited study. Metavir score...
Background and Purpose Squalene epoxidase (SQLE) is a key enzyme involved in cholesterol biosynthesis, but growing evidence also reveals that SQLE abnormally expressed some types of malignant tumours, even though the underlying mechanism remains poorly understood. Experimental Approach Bioinformatics analysis RNA sequencing were applied to detect differentially genes clinical hepatocellular carcinoma (HCC). MTT, colony formation, AnnexinV‐FITC/PI, EdU, wound healing, transwell, western blot,...
Abstract Metabolic abnormality is the major feature of laryngeal squamous cell carcinoma (LSCC), however, underlying mechanism remain largely elusive. Fatty acid desaturase 1 (FADS1), as key rate-limiting enzyme polyunsaturated fatty acids (PUFAs), catalyzes dihomo-gamma-linolenic (DGLA) to arachidonic (AA). In this study, we reported that expression FADS1 was upregulated in LSCC, high closely associated with advanced clinical features and poor prognosis recurrent LSCC patients after...
Background: With CRISPR-Cas9 genome editing tool in gene therapy, identifying aberrantly expressed genes is of great value across various cancer types. A large number patients may benefit from molecular targeted therapy. The purpose this study was to identify type, analyze prospective mechanism and theirs correlation with survival outcomes. Results NCAPG highly Cancer Genome Atlas (TCGA) database, which includes the transcriptomes 6647 647 normal tissue samples 16 Furthermore, a predicted...
The prognostic role of adjacent nontumor tissue in hepatocellular carcinoma (HCC) patients is still not clear. activity changes immunologic and hallmark gene sets tissues may substantially impact on prognosis by affecting proliferation liver cells colonization circulating tumor after HCC treatment measures such as hepatectomy. We aimed to identify subtypes based the tissues, improve patient outcomes. comprehensively revealed samples set variation analysis (GSVA), identified three clinically...
One of the remarkable metabolic characteristics cancer cells is that they prefer glycolysis rather than oxidative phosphorylation (OXPHOS). Pyruvate dehydrogenase E1 alpha subunit (PDHA1) an important prerequisite for OXPHOS. Our previous studies have shown low level PDHA1 protein expression in esophageal squamous cell (ESCC) was correlated with poor prognosis. However, effect inhibition on metabolism and biological behavior remains unclear.In this study, a KYSE450 knockout (KO) line...
Hepatitis A virus cellular receptor (HAVCR1) is a type-1 integral membrane glycoprotein that plays key role in immunity and renal regeneration abnormally expressed various tumor types. Nonetheless, the function of HAVCR1 pan-cancer remains unknown. In this study, we comprehensively analyzed expression promoter methylation level assessed immune cell infiltration, correlation between stromal admixture, CD (Cluster Differentiation) prognostic value mRNA Liver hepatocellular carcinoma (LIHC)...
Recently, type H vessels were reported to couple angiogenesis and osteogenesis during osteoclastogenesis, tartrate-resistant acid phosphatase (Trap)+ preosteoclasts found secrete increased PDGF-BB promote vessel formation. Therefore, utilization of may be a strategy treat diseases involving bone loss. In the present study, we that nuciferine, natural bioactive compound, has various effects, including inhibiting osteoclastogenesis promoting Nuciferine inhibited resorption but relative number...
Drought stress is a key limiting factor for cotton (Gossypium spp.) growth, production, development, and production worldwide. Some wild diploid species are remarkably tolerant of water deficit constitute an important reservoir understanding the molecular mechanisms Gossypium spp. drought tolerance improving cultivated upland cotton. Here, we utilized RNA-Seq technology to characterize leaf transcriptomes African species, anomalum, under stress. A total 12,322 differentially expressed genes...
Long non-coding RNAs (lncRNAs) have emerged as important regulators in cancer, including breast cancer.The precise expression pattern of long noncoding RNA 00899 (LINC00899) cancer and its mechanisms action not been reported.Here, we found that LINC00899 is downregulated tissues cell lines.Kaplan-Meier analysis showed elevated closely associated with better relapsefree survival (RFS) the basal, luminal A or B subtypes.Gene Ontology terms Kyoto Encyclopedia Genes Genomes pathway suggested...
The critical roles of TGFBR2/Smad2 signaling have been established in LPS-induced sepsis, however, the underlying mechanisms by which was regulated sepsis are still confused. Here, miRNA-based on RNA-sequencing dataset revealed that miR-145 significantly decreased human umbilical vein endothelial cells (HUVECs) following LPS treatment. Bioinformatics, luciferase reporter and RNA immune co-precipitation (RIP) assays showed could directly target TGFBR2 thus inactivated axis. On contrary,...
Although surgery is an important treatment for laryngeal cancer, has a significant negative impact on the quality of life patients, and many patients have poor tolerance to surgery. Therefore, alternative chemotherapeutic drugs are research hotspot. Chidamide histone deacetylase inhibitor that selectively inhibits expression type I IIb deacetylases (1, 2, 3 10). It anticancer effect variety solid tumours. This study verified inhibitory chidamide carcinoma. We conducted cellular animal...
As the critical components of tumor microenvironment, cancer-associated fibroblasts (CAFs) support development various type cancers, including laryngeal squamous cell carcinoma (LSCC), but detailed molecular mechanisms by which interact with LSCC cells to facilitate its progression have not been fully uncovered. In present study, analyzing contents from normal (NFs) and fibroblasts-derived extracellular vesicles (EVs) Real-Time qPCR analysis, we found that tumor-initiating LncRNA TUC338 was...
Because advanced laryngeal squamous cell carcinoma (LSCC) is diagnosed as a malignant tumor with poor prognosis, the associated mechanisms still need to be further investigated. As key players in development and progression of LSCC, lncRNAs have attracted increasing attention from many researchers. In this study, novel lncRNA termed IGKJ2-MALLP2 was identified investigated for its effects on LSCC. expression confirmed by RT-qPCR 78 pairs tissues human lines. The results study showed that...