A5057939990- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Cancer, Hypoxia, and Metabolism
- RNA Interference and Gene Delivery
- IL-33, ST2, and ILC Pathways
- Physiological and biochemical adaptations
- Bat Biology and Ecology Studies
- Medical Imaging Techniques and Applications
- Bone and Dental Protein Studies
- Bone health and treatments
- Cancer-related molecular mechanisms research
- CRISPR and Genetic Engineering
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver physiology and pathology
- Adipose Tissue and Metabolism
- Amphibian and Reptile Biology
- Cancer-related Molecular Pathways
- Fatty Acid Research and Health
- Phagocytosis and Immune Regulation
- Lung Cancer Research Studies
- Molecular Biology Techniques and Applications
- PI3K/AKT/mTOR signaling in cancer
- Neonatal Respiratory Health Research
- Cell death mechanisms and regulation
Sun Yat-sen University
2014-2025
Third Affiliated Hospital of Sun Yat-sen University
2014-2025
Soochow University
2024
Second Affiliated Hospital of Soochow University
2024
Dezhou University
2008-2024
Shougang (China)
2024
Second People's Hospital of Yunnan Province
2024
Guangdong Medical College
2009-2023
Wuhan National Laboratory for Optoelectronics
2012-2023
Massachusetts General Hospital
2017-2022
Lung cancers with activating KRAS mutations are characterized by treatment resistance and poor prognosis. In particular, the basis for their to radiation therapy is poorly understood. Here, we describe a phenotype conferred stem-like subpopulation mitosis-like condensed chromatin (MLCC), high CD133 expression, invasive potential, tumor-initiating properties. Mechanistic investigations defined pathway involving osteopontin EGFR in promoting this phenotype. Osteopontin/EGFR-dependent MLCC...
Abstract An unbalanced increase in dietary omega-6 (n-6) polyunsaturated fatty acids (PUFA) and decrease omega-3 (n-3) PUFA the Western diet coincides with global rise chronic diseases. Whether n-6 n-3 oppositely contribute to development of disease remains controversial. By using transgenic mice capable synthesizing eliminate confounding factors diet, we show here that alteration tissue n-6/n-3 ratio leads correlated changes gut microbiome fecal serum metabolites. Transgenic able...
Background: Activated hepatic stellate cells (aHSCs) regulate the function of immune during liver fibrosis. As major innate in liver, macrophages have inducible plasticity. Nevertheless, mechanisms through which aHSCs macrophages' phenotype and fibrosis cirrhosis remain unclear. In this study, we examined immunoregulatory explored their role regulating macrophage function. Methods: A total 96 patients with different stages chronic hepatitis B-related were recruited study. Metavir score...
Abstract Adjunctive chemotherapy with bisphosphonates has been reported to delay bone metastasis and improve overall survival in breast cancer. Aside from its antiresorptive effect, exhibit antitumor activities, vitro vivo , via several mechanisms, including antiangiogenesis. In this study, we investigated the potential molecular mechanisms underlying antiangiogenic effect of non–nitrogen‐containing nitrogen‐containing bisphosphonates, clodronate pamidronate, respectively, insulin‐like...
Numerous studies have shown that epigallocatechin-3-gallate (EGCG), a polyphenol component extracted from green tea, can inhibit the growth and induce apoptosis of various types human tumor cells. In this study, we evaluated inhibitory effects EGCG on proangiogenic capabilities A549 cells.A549 cells starved in serum-free culture medium for 24 h were pretreated with at concentrations (0, 10, 25, 50, 100 μmol/l) 1 h, followed by addition insulin-like factor-I (IGF-I) final concentration 40...
Objective:To analyze the efficacy and safety of entecavir (ETV) treatment for up to 5 years in nucleos(t)ide-naïve chronic hepatitis B patients real life.Methods: We retrospectively analyzed 230 nucleos(t)ide naïve who received ETV 0.5 mg/day monotherapy at least 3 months, whom 113 were HBeAg positive 117 negative.The primary endpoints was cumulative probability achieving a virological response (undetectable serum HBV DNA, <100IU/mL).Secondary rates ALT normalization (ALT < upper limit...
Background and aim Bile acid (BA) synthesis in the liver is regulated by Fibroblast Growth Factor 19 (FGF19) secreted from ileum as an enterohepatic feedback mechanism. Although FGF19 mRNA absent normal liver, gene expression was reported to increase response both extrahepatic intrahepatic cholestasis. The impact of upregulated on BA unclear overall role circulating under cholestatic conditions needs be further investigated. Methods directly quantified measuring serum concentrations...
Abstract Background Interleukin-33 (IL-33) is a well-recognized pleiotropic cytokine which plays crucial roles in immune regulation and inflammatory responses. Recent studies suggest that IL-33 its receptor ST2 are involved the pathogenesis of neurological diseases. Here, we explore effect IL-33/ST2 signaling neonatal hypoxic-ischemic (HI) brain injury elucidate underlying mechanisms action. Methods The HI model was established C57BL/6 mice by left common carotid artery occlusion with 90 min...
Background: Our previous studies have demonstrated that human papillomaviruse (HPV)-16 oncoproteins promoted epithelial-mesenchymal transition (EMT), leading to non-small cell lung cancer (NSCLC) progression, but the underlying molecular mechanisms still remain unclear. PI3K/Akt/HIF-1α signaling pathway has been reported mediate hypoxia-induced EMT. In this study, we further explored role of in HPV-16 oncoprotein-induced EMT NSCLC cells. Methods: A549 and NCI-H460 cells were transiently...
AbstractThe Xizang plateau frog, Nanorana parkeri (Anura: Dicroglossidae), enters a dormant state in the winter response to seasonal cold and lack of food. To investigate physiological ecological characteristics overwintering this species, we measured habitat conditions (hibernacula temperatures, body temperature, water quality variables), morphology, metabolite concentrations, total antioxidant capacity (T-AOC), bacteria-killing ability (BKA) plasma during summer winter. We found that N....
Our previous studies have found that human papillomavirus (HPV)-16 E7 oncoprotein promotes epithelial-mesenchymal transition (EMT) and hypoxia-inducible factor-1α (HIF-1α) protein accumulation in non-small cell lung cancer (NSCLC) cells monoamine oxidase A (MAOA) is highly expressed NSCLC tissues. Here, we further explored the role of MAOA HPV-16 E7-induced EMT HIF-1α A549 NCI-H460 cells. results showed enhanced expression Additionally, knockout inhibited migration, invasion, EMT,...
Abstract Background In response to seasonal cold and food shortage, the Xizang plateau frogs, Nanorana parkeri (Anura: Dicroglossidae), enter a reversible hypometabolic state where heart rate oxygen consumption in skeletal muscle are strongly suppressed. However, effect of winter hibernation on gene expression metabolic profiling these two tissues remains unknown. present study, we conducted transcriptomic metabolomic analyses from summer- winter-collected N. explore mechanisms involved...
Current guidelines for changing antiviral therapy regimens do not consider different baseline statuses. This study aimed to investigate whether significant prognostic differences exist among patients achieving virological response at various time points and these vary by viral load HBeAg status. retrospective cohort included 1,037 patients, who were classified based on their (high load, HVL, ≥ 7log10 IU mL-1: 522 individuals; or non-HVL, < 515 individuals) status (positive: 668 negative: 369...
Objectives The small noncoding RNAs (sncRNAs) including microRNAs and the noncanonical sncRNAs [i.e., tRNA-derived (tsRNAs) rRNA-derived (rsRNAs)] are a vital class of gene regulators in response to variety diseases. We focus on an sncRNA signature enriched hepatitis B virus (HBV)-related acute-on-chronic liver failure (ACLF) develop plasma exosome-based noninvasive biomarker for human ACLF. Methods In this work, related HBV-ACLF were identified by RNA sequencing (RNA-seq) exosomes collected...
Toxascaris leonina is one of the most common intestinal parasites canids and felids. In this study, we characterised entire mitochondrial (mt) genome sequence T. from cheetah compared it with that dog. The mt 14,685 bp in size, which 375 longer than dog, 408 South China tiger. overall nucleotide (except for non-coding region) identity was 92.8% between two genomes For 12 protein-coding genes, difference dog 5.0–9.7% at level 1.0–7.2% amino acid level. Moreover, comparison cox1 sequences...
Objectives . To compare entecavir (ETV) and tenofovir disoproxil fumarate (TDF) effects in chronic hepatitis B (CHB) patients with high HBV DNA. Method 96 treated initially (TDF group) or (ETV were included this retrospective study. The following parameters assessed: HBeAg e antibody (anti-HBe) status, serum alanine aminotransferase (ALT), HBV-DNA levels at weeks 4, 12, 24, 36, 48, 60, 72, 96; time to ALT normalization, undetectable levels, seroconversion; total duration of follow-up adverse...
IL-33 is a pleiotropic cytokine of the IL-1 family, which has been reported to implicate in both innate and adaptive immune responses. Recent studies suggest crucial for regulation myelopoiesis myeloid cell activity. Here, we explore potential effect against hematopoietic injury after total body irradiation (TBI). C57BL/6 mice were irradiated with sublethal dose radiation (600 cGy) treated at 3 μg/dose i.p. once day seven consecutive days. H&E staining was used determine bone marrow...
Bax inhibitor-1 (Bi-1), an anti-apoptotic protein that belongs to the Bcl-2 family, plays important role in mitochondrial apoptosis pathway suppress Bax-induced apoptosis. In several human cancers, including nasopharyngeal carcinoma, its expression was found be increased; however, up-regulated of this has been linked increased cell proliferations. study, we down-regulated gene Bi-1 carcinoma cells by using a lentivirus transfection system packed with short hairpin RNA targeting and used vivo...
The Rho-kinases (ROCK) inhibitor Y-27632 has been shown to promote the growth of epidermal cells, however, its potential effects on human dermal fibroblasts (HDFs) need be clarified. Here we show that prolonged treatment HDFs with decreased their by inducing senescence, which was associated induction senescence markers p16 and p21, downmodulation ERK pathways. senescent induced acquired a cancer-associated-fibroblast (CAF)-like phenotype squamous cell carcinoma (SCC) in vitro. Expression...