A5066236221- Lung Cancer Treatments and Mutations
- HER2/EGFR in Cancer Research
- Radiation Therapy and Dosimetry
- Radiopharmaceutical Chemistry and Applications
- Glioma Diagnosis and Treatment
- Cancer Cells and Metastasis
- Medical Imaging Techniques and Applications
- Renal and related cancers
- Cancer-related Molecular Pathways
- Bone and Dental Protein Studies
- Cancer, Hypoxia, and Metabolism
- Cancer Genomics and Diagnostics
- Hepatocellular Carcinoma Treatment and Prognosis
- Advanced Radiotherapy Techniques
- Renal cell carcinoma treatment
- Cancer Research and Treatments
- Childhood Cancer Survivors' Quality of Life
- Brain Metastases and Treatment
- Bone health and treatments
- Ethics and Legal Issues in Pediatric Healthcare
- Sarcoma Diagnosis and Treatment
- Vascular Malformations and Hemangiomas
- RNA modifications and cancer
- Chemical Reactions and Isotopes
- Lung Cancer Diagnosis and Treatment
University Hospital Carl Gustav Carus
2012-2023
Technische Universität Dresden
2008-2023
OncoRay
2008-2023
Helmholtz-Zentrum Dresden-Rossendorf
2017-2023
National Center for Tumor Diseases
2017-2023
Heidelberg University
2017-2023
German Cancer Research Center
2017-2023
University Hospital Heidelberg
2023
Klinik und Poliklinik für Strahlentherapie und Radioonkologie
2013-2016
London Health Sciences Centre
2013
Integrin signaling critically contributes to the progression, growth, and therapy resistance of malignant tumors. Here, we show that targeting β₁ integrins with inhibitory antibodies enhances sensitivity ionizing radiation delays growth human head neck squamous cell carcinoma lines in 3D culture xenografted mice. Mechanistically, dephosphorylation focal adhesion kinase (FAK) upon inhibition integrin resulted dissociation a FAK/cortactin protein complex. This, turn, downregulated JNK induced...
Lung cancers with activating KRAS mutations are characterized by treatment resistance and poor prognosis. In particular, the basis for their to radiation therapy is poorly understood. Here, we describe a phenotype conferred stem-like subpopulation mitosis-like condensed chromatin (MLCC), high CD133 expression, invasive potential, tumor-initiating properties. Mechanistic investigations defined pathway involving osteopontin EGFR in promoting this phenotype. Osteopontin/EGFR-dependent MLCC...
The transcription factor hypoxia-inducible factor-1 (HIF-1) pathway plays an important role in tumor response to cytotoxic treatments. We investigated the effects of a novel small molecule inhibitor mitochondrial complex I and hypoxia-induced HIF-1 activity BAY-87-2243, on microenvironment human squamous cell carcinoma (hSCC) clinically relevant fractionated radiotherapy (RT) with without concomitant chemotherapy.When UT-SCC-5 hSCC xenografts nude mice reached 6 mm diameter BAY-87-2243 or...
Recent clinical data have linked KRAS/TP53 comutation (mut) to resistance radiotherapy (RT), but supporting laboratory in vivo evidence is lacking. In addition, the ability of different radiation doses, with/without epidermal growth factor receptor (EGFR)-directed treatment, achieve local tumor control as a function KRAS status unknown. Here, we assessed clonogenic survival panel annotated lung cancer cell lines. KRASmut/TP53mut was associated with highest radioresistance nonisogenic and...
Abstract Purpose Several studies have demonstrated the negative impact of radiotherapy protocol deviations on tumor control in medulloblastoma. In SIOP PNET5 MB trial, a pretreatment quality (RT-QC) program was introduced. A first analysis for patients enrolled Germany, Switzerland and Austria with focus types initial plan proposals review criteria modern radiation technologies performed. Methods Sixty-nine craniospinal irradiation (CSI) plans were available detailed analyses. RT-QC...
In previous experiments an enhanced anti-proliterative effect of the EGFR/ErbB tyrosine kinase inhibitor (TKI) BIBW 2992 with single dose irradiation was observed in FaDu tumour xenografts. Aim present experiment to determine if this can also be seen combination a fractionated radiotherapy. Secondly we investigate efficacy on local control for UT-SCC-15. Tumour pieces FaDu, UT-SCC-14, A431, UT-SCC-15 (squamous cell carcinomas) and A7 (glioma) models were transplanted onto right hind leg NMRI...
Recently, the SIOP-RTSG developed a highly-conformal flank target volume definition for children with renal tumors. The aims of this study were to evaluate inter-clinician delineation variation new in an international multicenter setting and explore necessity quality assurance. Six pediatric cancer cases transferred ten radiation oncologists from seven European countries ('participants'). These participants delineated pre- postoperative Gross Tumor Volume (GTVpre/post), Clinical Target (CTV)...
In Germany, Austria, and Switzerland, pretreatment radiotherapy quality control (RT-QC) for tumor bed boost (TB) in non-metastatic medulloblastoma (MB) was not mandatory but recommended patients enrolled the SIOP PNET5 MB trial between 2014 2018. This individual case review (ICR) analysis aimed to evaluate types of deviations initial plan proposals develop uniform criteria TB boost.A total 78 were registered this trial, whom a subgroup 65 available evaluation treatment plans. Dose uniformity...
Cancer research faces the problem of high rates clinical failure new treatment approaches after positive preclinical data. We hypothesize that a major confounding factor to this in radiooncology is choice endpoint.We present comprehensive re-evaluation large-scale in-vivo data on fractionated irradiation alone or simultaneously with Epidermal Growth Factor Receptor inhibition. Taking permanent local tumour control assay as gold standard, we evaluated different volume dependent endpoints are...
Abstract We report about a female toddler congenitally deaf and diagnosed with non-metastatic desmoplastic medulloblastoma (SHH activated, TP53-wt, variant in LDB1 gene). No tumor predisposition syndrome was found. After complete resection the patient treated according to I-HIT-MED-Guidance protocol. Five months later an asymptomatic localised relapse (same histology, PTEN frameshift deletion, TERT mutation, mutation) detected by routine MRI resection, craniospinal irradiation antiangiogenic...