A5053519063- Radiation Therapy and Dosimetry
- Advanced Radiotherapy Techniques
- Glioma Diagnosis and Treatment
- Prostate Cancer Diagnosis and Treatment
- Ocular Oncology and Treatments
- Head and Neck Cancer Studies
- Brain Metastases and Treatment
- Radiopharmaceutical Chemistry and Applications
- Meningioma and schwannoma management
- Radiation Detection and Scintillator Technologies
- Sarcoma Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Advanced X-ray and CT Imaging
- Vascular Malformations Diagnosis and Treatment
- Corneal Surgery and Treatments
- Lung Cancer Treatments and Mutations
- Head and Neck Surgical Oncology
- Prostate Cancer Treatment and Research
- Radiation Effects and Dosimetry
- Management of metastatic bone disease
- ATP Synthase and ATPases Research
- COVID-19 and healthcare impacts
- Nuclear Physics and Applications
- Hearing, Cochlea, Tinnitus, Genetics
- Body Contouring and Surgery
TU Dortmund University
2023
Essen University Hospital
2004-2022
Deutschen Konsortium für Translationale Krebsforschung
2019-2022
West German Heart and Vascular Center Essen
2009-2022
German Cancer Research Center
2019-2021
University of Duisburg-Essen
2021
Consorzio Milano Ricerche
2019
Università Cattolica del Sacro Cuore
2019
Charité - Universitätsmedizin Berlin
2000-2005
Humboldt-Universität zu Berlin
2000-2004
To report the results and corresponding acute late reactions of a prospective, randomized, clinical study in locally advanced head neck cancer comparing concurrent fluorouracil (FU) mitomycin (MMC) chemotherapy hyperfractionated accelerated radiation therapy (C-HART; 70.6 Gy) to alone (HART; 77.6 Gy).Three hundred eighty-four stage III (6%) IV (94%) oropharyngeal (59.4%), hypopharyngeal (32.3%), oral cavity (8.3%) patients were randomly assigned receive either 30 Gy (2 every day) followed by...
Abstract Purpose Several studies have demonstrated the negative impact of radiotherapy protocol deviations on tumor control in medulloblastoma. In SIOP PNET5 MB trial, a pretreatment quality (RT-QC) program was introduced. A first analysis for patients enrolled Germany, Switzerland and Austria with focus types initial plan proposals review criteria modern radiation technologies performed. Methods Sixty-nine craniospinal irradiation (CSI) plans were available detailed analyses. RT-QC...
Proton therapy makes use of the favorable depth-dose distribution with its characteristic Bragg peak to spare normal tissue distal target volume. A steep dose gradient would be desired in lateral dimensions, too. The widespread spot scanning delivery technique is based, however, on pencil-beams in-air full-widths-at-half-maximum typically 1 cm or more. This hampers sparing organs-at-risk if small-scale structures adjacent volume are concerned. trimming fields collimating apertures...
To evaluate the impact of beam quality in terms distal fall-off (DFO, 90%-10%) and lateral penumbra (LP, 80%-20%) single ocular proton therapy (OPT) to derive resulting ideal requirements for future systems.Nine different models with DFO varying between 1 4 mm LP were created. Beam incorporated into RayStation RayOcular treatment planning system version 10 B (RaySearch Laboratories, Stockholm, Sweden). Each model was applied eight typical clinical cases, covering sizes locations uveal...
Pencil beam scanning (PBS) proton therapy enables better dose conformality for complex anatomical geometries than passive scattering techniques, but is more susceptible to organ motion. This becomes an issue when treating moving tumours in the thorax or abdomen. Novel four-dimensional treatment planning approaches have been developed increase robustness of PBS plans against However, their efficacy still needs be examined by means 4D dynamically accumulated (4DDD) analyses. study investigates...
Despite the increased risk of subsequent primary tumors (SPTs) external beam radiation (EBRT) may be only therapeutic option to preserve a retinoblastoma eye. Due their physical properties, proton therapy (PBT) offers possibility use effectiveness EBRT in tumor treatment and decisively reduce treatment-related morbidity. We report our experiences PBT as rescue retrospectively studied cohort 15 advanced eyes final for eye-preserving therapy. The average age at initiation was 35 (14–97)...
Retinoblastoma and other eye tumors in childhood are rare diseases. Many the first signs of a genetic tumor predisposition syndrome affected children carry higher risk developing cancers later life. Clinical data all with diagnosed between 2013–2018 Germany Austria were collected multicenter prospective observational study. In five years, 300 recruited into study: 287 retinoblastoma, 7 uveal melanoma, 3 ciliary body medulloepithelioma, 2 retinal astrocytoma, 1 meningioma optic nerve...
Proton radiotherapy of the prostate basal or whole seminal vesicles using scattering delivery systems is an effective treatment cancer that has been evaluated in prospective trials. Meanwhile, use pencil beam scanning (PBS) can further reduce dose entrance channels and to normal tissues. However, PBS distributions be affected by intra‐ interfractional motion. In this planning study, effects organ motion on are investigated repeated CT scans at close distant time intervals. The minimum ( ) 2%...
<b><i>Introduction:</i></b> Given the rarity of retinoblastoma and consequences accidental vitrectomy in event misdiagnosis, reporting on clinical experience this area is important. <b><i>Objective:</i></b> The aim study was to analyse management complications with a focus local orbital recurrence metastatic disease 10 children vitrectomized an undetected eye. <b><i>Methods:</i></b> This retrospective descriptive case...
In Germany, Austria, and Switzerland, pretreatment radiotherapy quality control (RT-QC) for tumor bed boost (TB) in non-metastatic medulloblastoma (MB) was not mandatory but recommended patients enrolled the SIOP PNET5 MB trial between 2014 2018. This individual case review (ICR) analysis aimed to evaluate types of deviations initial plan proposals develop uniform criteria TB boost.A total 78 were registered this trial, whom a subgroup 65 available evaluation treatment plans. Dose uniformity...
Abstract Background Eye‐preserving therapy in retinoblastoma comprises systemic chemotherapy, but studies analyzing the efficacy of different chemotherapy regimens are scarce. Methods The and side effects two eye‐preserving containing either vincristine, etoposide, carboplatin (VEC) or cyclophosphamide, (CyVEC) were compared a prospective non‐interventional observational study including children diagnosed with between 2013 2019 Germany Austria. Event‐free eye survival (EFES) overall (OES)...
The aim of this study is to examine the dosimetric influence endorectal balloons (ERB) on rectal sparing in prostate cancer patients with implanted hydrogel rectum spacers treated dose-escalated or hypofractionated intensity-modulated proton beam therapy (IMPT).Ten localized included ProRegPros and at our center were investigated. All underwent placement before planning. Two planning CTs (with without 120 cm3 fluid-filled ERB) applied for each patient. Dose prescription was set according h...
The treatment of moving targets is a challenging task using high conformal radiation techniques such as pencil beam scanning (PBS) proton therapy and requires adequate motion mitigation. Recent guidelines propose 4D robust optimization to mitigate artefacts in PBS thoracic malignancies. However, the availability dosimetric analyses supporting this recommendation limited even non-existing for other tumour sites. objective study was therefore analyse effectiveness hepatocellular carcinoma...
Adequate management of retinoblastoma requires a multidisciplinary and individual approach to treatment. Intraarterial chemotherapy (IAC) is one the most commonly used treatment modalities, enables supraselective application via ophthalmic artery now established in almost all centres. However, published success rates are heterogeneous. There some unanswered issues regarding sight-threatening ocular complications long-term occurrence secondary malignancies metastatic disease. The objective...