A5034551071- Antibiotics Pharmacokinetics and Efficacy
- Analytical Methods in Pharmaceuticals
- Analytical Chemistry and Chromatography
- Pharmaceutical and Antibiotic Environmental Impacts
- Dental Anxiety and Anesthesia Techniques
- Drug Transport and Resistance Mechanisms
- Anesthesia and Sedative Agents
- Pharmacogenetics and Drug Metabolism
- Pharmacological Effects and Toxicity Studies
- Analytical chemistry methods development
- SARS-CoV-2 detection and testing
- Anesthesia and Pain Management
- Plant-based Medicinal Research
- Venous Thromboembolism Diagnosis and Management
- COVID-19 Clinical Research Studies
- Heparin-Induced Thrombocytopenia and Thrombosis
- Receptor Mechanisms and Signaling
- Blood Pressure and Hypertension Studies
- Neuroscience and Neuropharmacology Research
- Water Treatment and Disinfection
- Poisoning and overdose treatments
- Cholinesterase and Neurodegenerative Diseases
- Biosensors and Analytical Detection
- Inflammatory Bowel Disease
- Medical History and Innovations
Technische Universität Dresden
2015-2025
University Hospital Carl Gustav Carus
2012-2024
Columbus Oncology and Hematology Associates
2018
University of Florida
2018
Institute of Pharmacology
2010
Klinik und Poliklinik für Psychotherapie und Psychosomatik
1994-2009
University of Technology - Iraq
2008
London Health Sciences Centre
2005
Vanderbilt University
2005
Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology
2005
Abstract Background and aims Wastewater‐based epidemiology is an additional indicator of drug use that gaining reliability to complement the current established panel indicators. The this study were to: (i) assess spatial temporal trends population‐normalized mass loads benzoylecgonine, amphetamine, methamphetamine 3,4‐methylenedioxymethamphetamine (MDMA) in raw wastewater over 7 years (2011–17); (ii) address overall by estimating average number combined doses consumed per day each city;...
It is unclear whether improved metabolism or a "lipid sink" effect of lipid infusion responsible for the positive effects in local anesthetic-induced myocardial depression.We used an isolated rat heart, constant-pressure perfused, nonrecirculating Langendorff preparation and exposed hearts to 5 mug/mL l-bupivacaine 9 microL/mL emulsion. Hearts were freeze-clamped energy was charge measured by HPLC. In second experiment pacing evaluated. The addition on anesthetic concentrations...
Flavonoids are phytochemicals and belong to the polyphenols. A wide variety of beneficial factors has been attributed their mode action. Some activities concerns inhibition inflammatory pathways down regulation genes involved in chronic disease states. These enhance signaling leading expression cytokines chemokines. from fruits, vegetable tea compounds can block many proinflammatory proteins thus function as natural inhibitors inflammation. Instead using nonsteroidal anti-inflammatory drugs...
Objectives Our objectives were to evaluate the effect of single and repeated grapefruit juice ingestion relative water on oral pharmacokinetics nonmetabolized P-glycoprotein-transported drug talinolol in humans assess potential impact P-glycoprotein intestinal uptake transporters. Methods The 50 mg was determined with water, 1 glass (300 mL), after 6 days (900 mL/d) 24 healthy white volunteers. MDR1 messenger ribonucleic acid levels measured duodenal biopsy specimens obtained from 3...
Increased bioavailability of the P-glycoprotein (Pgp) substrates digoxin and cyclosporin due to erythromycin has been observed in vivo. The aim present study was investigate effect orally administered on oral beta-blocker talinolol. Talinolol is a suitable model compound for Pgp drug-drug interaction studies its Pgp-related active intestinal secretion lack any significant metabolism.In randomized crossover study, pharmacokinetics talinolol (50 mg) after concomitant single dose (2 g) or...
St John's wort (SJW) is known to induce cytochrome P450 (CYP) 3A4 and P-glycoprotein through pregnane X-receptor activation. Our study evaluated the effects of long-term SJW administration on oral intravenous pharmacokinetics nonmetabolized in vivo probe P-glycoprotein, talinolol, relation intestinal expression. In a controlled, randomized (N=9), (50 mg) talinolol (30 was determined before after 12 days (900 mg daily, Jarsin 300®). Duodenal biopsies were taken MDR1 genotypes assessed....
Objective To examine the relevance of site-dependent small intestinal absorption for incomplete poorly metabolized β1-adrenergic receptor antagonist talinolol. Methods The steady-state perfusion technique (triple lumen tubing system with a 30 cm test segment) intraluminal measurements was combined simultaneous determination talinolol serum concentrations. Dissolved perfused over 160 minutes into different parts intestine. middle segment located between 95 and 235 beyond teeth. Each six...
Dependent on the excretion pattern, wastewater monitoring of viruses can be a valuable approach to characterizing their circulation in human population. Using polyethylene glycol precipitation and reverse transcription-quantitative PCR, occurrence RNA SARS-CoV-2 influenza A/B raw two treatment plants Germany between January May 2022 was investigated. Due relatively high incidence both exposal areas (plant 1 plant 2), SARS-CoV-2-specific determined all 273 composite samples analyzed...
Use of wastewater-based epidemiology as a tool to record and manage the course SARS-CoV-2 infections in human populations requires information about efficiency methods concentrate virus from wastewater. In present study, we spiked untreated wastewater with quantified positive clinical material enriched by polyethylene glycol precipitation ultrafiltration Vivaspin 10 kDa MWCO columns. was detected reverse transcription quantitative PCR (E- S-gene) droplet digital PCR. The concentration...
Mutations of the CBP/p300 histone acetyltransferase (HAT) domain can be linked to leukemic transformation in humans, suggestive a checkpoint leukocyte compartment sizes. Here, we examined impact reversible inhibition this by small-molecule A485. We found that A485 triggered acute and transient mobilization leukocytes from bone marrow into blood. Leukocyte was equally potent as, but mechanistically distinct from, granulocyte colony-stimulating factor (G-CSF), which allowed for additive...
Vancomycin-resistant (VR) Enterococcus spp. can be detected in high concentrations wastewaters and pose a risk to public health. During one-year study (September 2022–August 2023), 24 h composite raw wastewater samples (n = 192) of municipal treatment plant were investigated for cultivable enterococci. After growth on Slanetz–Bartley agar (SBA), mean concentration 29,736 ± 9919 cfu/mL was calculated. Using MALDI-TOF MS characterize randomly picked colonies 576), the most common species found...
To examine the secretion of beta1-adrenergic receptor antagonist talinolol into small intestine during its intravenous administration and to show relevance P-glycoprotein-modulating drug verapamil for this secretory transport mechanism in humans.In six healthy volunteers intestinal steady-state perfusion technique (triple lumen tubing system) was used measuring appearance within while infused intravenously. During four seven perfusions performed, fluid changed from a verapamil-free solution...
The effects of subcutaneously administered scopolamine on quantitative electroencephalogram (qEEG) and cognitive performance were evaluated correlated with pharmacokinetic parameters in a randomized, double‐blind placebo‐controlled crossover study 10 healthy male volunteers. Changes qEEG cognition determined for 8 hours after drug administration. Scopolamine produced dose‐ time‐dependent impairments attention memory increase delta power (1.25‐4.50 Hz) decrease fast alpha (9.75‐12.50 compared...