A5037808517- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Pain Management
- Anesthesia and Neurotoxicity Research
- Sepsis Diagnosis and Treatment
- Cardiac Ischemia and Reperfusion
- Innovations in Medical Education
- Anesthesia and Sedative Agents
- Hemodynamic Monitoring and Therapy
- Cardiac Arrest and Resuscitation
- COVID-19 and healthcare impacts
- Intensive Care Unit Cognitive Disorders
- Radiopharmaceutical Chemistry and Applications
- Organ Transplantation Techniques and Outcomes
- Simulation-Based Education in Healthcare
- Trauma and Emergency Care Studies
- Medical Imaging Techniques and Applications
- Cardiac Imaging and Diagnostics
- Hip and Femur Fractures
- Fatty Acid Research and Health
- SARS-CoV-2 and COVID-19 Research
- Respiratory Support and Mechanisms
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Renal Transplantation Outcomes and Treatments
- Nitric Oxide and Endothelin Effects
Leipzig University
2017-2024
University Hospital Leipzig
2017-2024
Klinik und Poliklinik für Neurologie
2024
Jena University Hospital
2012-2022
University of Lübeck
2015-2019
University Hospital Schleswig-Holstein
2015-2019
Universität Hamburg
2018
University Medical Center Hamburg-Eppendorf
2018
Committee on Publication Ethics
2018
University of Duisburg-Essen
2017-2018
Remote ischemic preconditioning (RIPC) is reported to reduce biomarkers of and reperfusion injury in patients undergoing cardiac surgery, but uncertainty about clinical outcomes remains.We conducted a prospective, double-blind, multicenter, randomized, controlled trial involving adults who were scheduled for elective surgery requiring cardiopulmonary bypass under total anesthesia with intravenous propofol. The compared upper-limb RIPC sham intervention. primary end point was composite death,...
Summary Ropivacaine 1% 40 ml was mistakenly injected as part of an axillary plexus block in 84‐year‐old woman. After 15 min the patient complained dizziness and drowsiness developed a generalised tonic‐clonic seizure followed by asystolic cardiac arrest. 10 unsuccessful cardiopulmonary resuscitation, bolus 100 Intralipid 20% (2 ml.kg −1 ) administered continuous infusion ml.min . total dose 200 had been given spontaneous electrical activity output restored. The recovered completely. We...
As of late 2019, the COVID-19 pandemic has been a challenge to health care systems worldwide. Rapidly rising local incidence rates, result in demand for high hospital and intensive bed capacities on short notice. A detailed up-to-date regional surveillance dynamics pandemic, precise prediction required inpatient as well centralized coordination distribution patient fluxes is needed ensure optimal care. In March 2020, German federal state Saxony established three centers located at each its...
Only a few data exist about the occurrence of emergencies in dental practice and training experience teams life support. This study evaluates incidence practices, attitude dentists towards emergency management their experience.Anonymous questionnaires were sent to all 2998 listed Saxony State Dental Council Register January 2005.620 returned. 77% responders expressed an interest 84% stated that they owned bag. In 12-month period, 57% reported up 3 36% 10 emergencies. Vasovagal syncope was...
In Brief A 91-yr-old man (57 kg, 156 cm, ASA III) received an infraclavicular brachial plexus block for surgery of bursitis the olecranon. Twenty minutes after injection 30 mL mepivacaine 1% (Scandicain®) and 5 min supplementation 10 prilocaine (Xylonest®) using axillary approach, patient complained agitation dizziness became unresponsive to verbal commands. addition, supraventricular extrasystole with bigeminy occurred. Local anesthetic toxicity was suspected a dose 200 20% lipid emulsion...
It is unclear whether improved metabolism or a "lipid sink" effect of lipid infusion responsible for the positive effects in local anesthetic-induced myocardial depression.We used an isolated rat heart, constant-pressure perfused, nonrecirculating Langendorff preparation and exposed hearts to 5 mug/mL l-bupivacaine 9 microL/mL emulsion. Hearts were freeze-clamped energy was charge measured by HPLC. In second experiment pacing evaluated. The addition on anesthetic concentrations...
Abstract Background Myocardial involvement induced by SARS-CoV-2 infection might be important for long-term prognosis. The aim of this observational study was to characterize the myocardial effects during infections echocardiography. Results and methods An extended echocardiographic image acquisition protocol performed in 18 patients with assessing LV longitudinal, radial, circumferential deformation including rotation, twist, untwisting. Furthermore, analyzed an age-matched control group...
Thrombomodulin (TM), via its lectin-like domain (LLD), exhibits anti-inflammatory properties partly by sequestering the pro-inflammatory cytokine, high-mobility group box 1 (HMGB1). Since myocardial damage after ischaemia and reperfusion is mediated inflammation, we evaluated cardioprotective effects of LLD TM. Using an in vivo mouse model transient vitro models cardiomyocyte hypoxia, assessed ability to suppress HMGB1-mediated activation receptors, receptor for advanced glycation...
Patients in intensive care units (ICU) are often diagnosed with postoperative delirium; the duration of which has a relevant negative impact on various clinical outcomes. Recent research found potentially important role acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) delirium critically ill patients non-surgical ICU or non-cardiac-surgery patients. We tested hypothesis that AChE BChE have an after cardiac surgery delirium.After obtaining approval from local ethics committee,...
Background Remote ischemic preconditioning ( RIPC ) has been suggested to protect against certain forms of organ injury after cardiac surgery. Previously, we reported the main results RIPHeart (Remote Ischemic Preconditioning for Heart Surgery) Study, a multicenter trial randomizing 1403 surgery patients receiving either or sham‐ . Methods and Results In this follow‐up paper, present 1‐year composite primary end point its individual components (all‐cause mortality, myocardial infarction,...
Enhancers are genomic regulatory elements conferring spatiotemporal and signal-dependent control of gene expression. Recent evidence suggests that enhancers can generate noncoding enhancer RNAs, but their (patho)biological functions remain largely elusive.We performed chromatin immunoprecipitation-coupled sequencing histone marks combined with RNA left ventricular biopsies from experimental genetic mouse models human cardiac hypertrophy to identify transcripts revealing localization,...
The aim of our study was the identification genetic variants associated with postoperative complications after cardiac surgery. We conducted a prospective, double-blind, multicenter, randomized trial (RIPHeart). performed genome-wide association (GWAS) in 1170 patients both genders (871 males, 299 females) from RIPHeart-Study cohort. Patients undergoing non-emergent surgery were included. Primary endpoint comprises binary composite complication rate covering atrial fibrillation, delirium,...
Background Extracorporeal Membrane Oxygenation (ECMO) use is increasing despite limited evidence. The aim of this study was to demonstrate heterogeneity ECMO and its association with hospital size annual frequency in Germany. Methods This a database analysis all cases Germany from 2010 2016 using the German Diagnosis Related Groups (DRG) coding system for ECMO. Results During period, 510 hospitals performed 29,929 runs (12,572 vvECMO, 11,504 vaECMO, 1993 pECLA) an increase over time....
Understanding SARS-CoV-2 breakthrough infections in vaccinated healthcare workers is of key importance mitigating the effects COVID-19 pandemic facilities. An observational prospective cohort study was conducted employees with acute infection between October 2021 and February 2022. Serological molecular testing performed to determine viral load, lineage, antibody levels, neutralizing titers. A total 571 (9.7%) experienced during enrolment period, which 81 were included. The majority (n = 79,...
IN recent years newly developed antiplatelet drugs such as the thienopyridine derivatives ticlopidine and clopidogrel are being increasingly used in patients with cardiovascular disease. Knowledge of their pharmacokinetics is crucial for appropriate perioperative care. Therefore, updated guidelines concomitant use these locoregional anesthesia have been issued by American Society Regional Anesthesia Pain Medicine1and European societies anesthesiologists2concerning a risk-benefit ratio well...
Background Management of cardiac surgery patients is a very standardized procedure in respective local institutions. Yet only limited evidence exists concerning optimal indication, safety and efficacy hemodynamic monitoring catecholamine fluid therapy. Methods Between April May 2013, all 81 German anaesthesia departments involved care were asked to participate questionnaire addressing the institutional specific current practice monitoring, volume Results 51 (63%) questionnaires completed...
Cardiac dysfunction, in particular of the left ventricle, is a common and early event sepsis, strongly associated with an increase patients' mortality. Acid sphingomyelinase (SMPD1)-the principal regulator for rapid transient generation lipid mediator ceramide-is involved both regulation host response sepsis as well pathogenesis chronic heart failure. This study determined degree potential role to which SMPD1 its modulation affect sepsis-induced cardiomyopathy using genetically deficient...
Technetium-labeled fatty acids intended for myocardial metabolism imaging and the respective rhenium model complexes were synthesized according to "4 + 1" mixed-ligand approach investigated in vitro vivo. The non-radioactive characterized by NMR, IR, EA, geometrical impact of chelate unit on integrity acid head structure was determined single-crystal X-ray analyses. To estimate diagnostic value 99mTc-labeled acids, compounds experiments biodistribution studies using male Wistar rats. new...
Immunological interventions in endotoxemia and sepsis have been tested experimental clinical studies. Our group evaluated the effects of an immunoglobulin (Ig)M-enriched solution established model Gram-negative bacteraemia. Ten New Zealand White rabbits (2-3 kg) were randomized to a treatment or control group. In both groups, LPS was infused at rate 40 mg kg(-1) h(-1). Immunoglobulin M-enriched (Pentaglobin; 2 mL h(-1)) applied intervention 15 min after beginning infusion. 1 x 10(8) colony...