A5040747569- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Pain Management
- Cancer Treatment and Pharmacology
- Multiple Myeloma Research and Treatments
- Blood transfusion and management
- Neonatal Respiratory Health Research
- Testicular diseases and treatments
- Nausea and vomiting management
- Pain Management and Opioid Use
- Anesthesia and Neurotoxicity Research
- Erythropoietin and Anemia Treatment
- Respiratory Support and Mechanisms
- Palliative Care and End-of-Life Issues
- Intensive Care Unit Cognitive Disorders
- Cardiac Arrest and Resuscitation
- Music Therapy and Health
- Family and Patient Care in Intensive Care Units
- Cardiac Ischemia and Reperfusion
- Pain Management and Placebo Effect
- Cannabis and Cannabinoid Research
- Intraoperative Neuromonitoring and Anesthetic Effects
- Pain Mechanisms and Treatments
- Cardiac tumors and thrombi
- Cardiac Arrhythmias and Treatments
- Ocular Diseases and Behçet’s Syndrome
Johannes Gutenberg University Mainz
2014-2023
University Medical Center of the Johannes Gutenberg University Mainz
2014-2023
Hospital Israelita Albert Einstein
2017
Faculdade de Medicina do ABC
2017
University Hospital Carl Gustav Carus
2017
Amsterdam UMC Location University of Amsterdam
2017
University of Amsterdam
2017
Remote ischemic preconditioning (RIPC) is reported to reduce biomarkers of and reperfusion injury in patients undergoing cardiac surgery, but uncertainty about clinical outcomes remains.We conducted a prospective, double-blind, multicenter, randomized, controlled trial involving adults who were scheduled for elective surgery requiring cardiopulmonary bypass under total anesthesia with intravenous propofol. The compared upper-limb RIPC sham intervention. primary end point was composite death,...
Selenium contributes to antioxidative, anti-inflammatory, and immunomodulatory pathways, which may improve outcomes in patients at high risk of organ dysfunctions after cardiac surgery.To assess the ability high-dose intravenous sodium selenite treatment reduce postoperative dysfunction mortality surgery patients.This multicenter, randomized, double-blind, placebo-controlled trial took place 23 sites Germany Canada from January 2015 2021. Adult with a European System for Cardiac Operative...
Pain after surgery is a major issue for patient discomfort and often associated with delayed recovery. The aim of the present study was to evaluate prevalence pain requirement analgesics up 6 months elective surgery, independent if new symptoms occurred or preoperative persisted in postoperative period.A prospective observational single center cohort conducted between January 2012 August 2013. Eligible patients were scheduled undergo surgical interventions including joint (hip, knee...
Background Remote ischemic preconditioning ( RIPC ) has been suggested to protect against certain forms of organ injury after cardiac surgery. Previously, we reported the main results RIPHeart (Remote Ischemic Preconditioning for Heart Surgery) Study, a multicenter trial randomizing 1403 surgery patients receiving either or sham‐ . Methods and Results In this follow‐up paper, present 1‐year composite primary end point its individual components (all‐cause mortality, myocardial infarction,...
BACKGROUND Postoperative nausea and vomiting (PONV) is an extremely distressing side effect for patients. Despite PONV prophylaxis guided by well established scoring systems, the incidence of still high. OBJECTIVE The aim current study was to investigate predictive value anxiety sensitivity as additional independent risk factor in patients with increased PONV. DESIGN A noninterventional, observational study. SETTING tertiary care university hospital. PATIENTS Patients (i.e. female,...
BACKGROUND Postoperative pulmonary complications (PPCs) are common after major abdominal surgery. The kinetics of plasma biomarkers could improve identification patients developing PPCs, but the may depend on intraoperative ventilator settings. OBJECTIVE To test whether capable identifying who will develop and level positive end-expiratory pressure (PEEP). DESIGN A preplanned substudy a randomised controlled trial. SETTING Operation room five centres. PATIENTS Two hundred forty-two adult...
The aim of our study was the identification genetic variants associated with postoperative complications after cardiac surgery. We conducted a prospective, double-blind, multicenter, randomized trial (RIPHeart). performed genome-wide association (GWAS) in 1170 patients both genders (871 males, 299 females) from RIPHeart-Study cohort. Patients undergoing non-emergent surgery were included. Primary endpoint comprises binary composite complication rate covering atrial fibrillation, delirium,...
Perioperative anaemia leads to impaired oxygen supply with a risk of vital organ ischaemia. In healthy and fit individuals, can be compensated by several mechanisms. Elderly patients, however, have less compensatory mechanisms because multiple co-morbidities age-related decline functional reserves. The purpose the study is evaluate whether elderly surgical patients may benefit from liberal red blood cell (RBC) transfusion strategy compared restrictive strategy.The LIBERAL Trial prospective,...
Ongoing pain after surgery is a major problem and influences recovery the quality of life patient. Associations between anxiety their impact on postoperative herniated disc have been reported, but results are inconsistent. The aim present longitudinal study was to evaluate predictive value preoperative for ongoing prolonged analgesic intake surgery. 106 patients with lumbar herniation were evaluated in study. Anxiety measured Generalized Disorder 7-Item Scale (GAD-7) before Pain intensity...
Zusammenfassung Die Bedeutung moderner Intensivmedizin für schwerstkranke Patienten ist unbestritten. Dennoch stellt sich die Frage nach der Sinnhaftigkeit maximaler Intensivtherapie, wenn sie zwar eine Lebensverlängerung erreicht, aber Lebensqualität stark beeinträchtigt. Mit dem Wissen und Akzeptanz, realistische Therapieziele im Sinne des festzulegen, gewinnen palliativmedizinische Aspekte auf Intensivstation zunehmend an Bedeutung.
BACKGROUND Biological phenotypes have been identified within several heterogeneous pulmonary diseases, with potential therapeutic consequences. OBJECTIVE To assess whether distinct biological exist surgical patients, and development of postoperative complications (PPCs) subsequent dependence intra-operative positive end-expiratory pressure (PEEP) differ between such phenotypes. SETTING Operating rooms six hospitals in Europe USA. DESIGN Secondary analysis the 'PROtective Ventilation HIgh or...
Abstract Background Patients with multiple myeloma report more problems quality of life (QoL) than other haematological malignancies over the course their incurable illness. The patient-centred Myeloma Patient Outcome Scale (MyPOS) was developed to assess and monitor symptoms supportive care factors in routine care. Our aim translate culturally adapt outcome measure German context, explore its face content validity. Methods Translation cultural adaptation following established guidelines...
Abstract Background: Perioperative anaemia leads to impaired oxygen supply with a risk of vital organ ischaemia. In healthy and fit individuals, can be compensated by several mechanisms. Elderly patients, however, have less compensatory mechanisms because multiple co-morbidities aging-related decline functional reserves. The purpose the study is evaluate whether elderly surgical patients may benefit from liberal red blood cell (RBC) transfusion strategy compared restrictive strategy....
Abstract Background: Perioperative anaemia leads to impaired oxygen supply with a risk of vital organ ischaemia. In healthy and fit individuals, can be compensated by several mechanisms. Elderly patients, however, have less compensatory mechanisms because multiple co-morbidities aging-related decline functional reserves. The purpose the study is evaluate whether elderly surgical patients may benefit from liberal red blood cell (RBC) transfusion strategy compared restrictive strategy....
Abstract Background: Perioperative anaemia leads to impaired oxygen supply with a risk of vital organ ischaemia. In healthy and fit individuals, can be compensated by several mechanisms. Elderly patients, however, have less compensatory mechanisms because multiple co-morbidities aging-related decline functional reserves. The purpose the study is evaluate whether elderly surgical patients may benefit from liberal red blood cell (RBC) transfusion strategy compared restrictive strategy....
Abstract Background Patients with multiple myeloma report more problems quality of life (QoL) than other haematological malignancies over the course their incurable illness. The patient-centred Myeloma Patient Outcome Scale (MyPOS) was developed to assess and monitor symptoms supportive care factors in routine care. Our aim translate culturally adapt outcome measure German context, explore its face content validity. Methods Translation cultural adaptation following established guidelines...
Abstract Background Patients with multiple myeloma report more problems quality of life (QoL) than other haematological malignancies over the course their incurable illness. The patient-centred Myeloma Patient Outcome Scale (MyPOS) was developed to assess and monitor symptoms supportive care factors in routine care. Our aim translate culturally adapt outcome measure German context, explore its face content validity. Methods Translation cultural adaptation following established guidelines...