A5068932701- Advanced Banach Space Theory
- Approximation Theory and Sequence Spaces
- Holomorphic and Operator Theory
- Advanced Topics in Algebra
- Lung Cancer Treatments and Mutations
- Matrix Theory and Algorithms
- Colorectal Cancer Treatments and Studies
- Cancer Treatment and Pharmacology
- Fixed Point Theorems Analysis
- Lung Cancer Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- Cancer Genomics and Diagnostics
- Cell Adhesion Molecules Research
- Polynomial and algebraic computation
- Corporate Governance and Management
- Optimization and Variational Analysis
- Lung Cancer Research Studies
- Palliative Care and End-of-Life Issues
- Testicular diseases and treatments
- advanced mathematical theories
- Noise Effects and Management
- Advanced Operator Algebra Research
- Rings, Modules, and Algebras
- Occupational Health and Safety Research
- Economic and Financial Impacts of Cancer
Technische Universität Dresden
2007-2023
University Medical Center of the Johannes Gutenberg University Mainz
2016-2020
Johannes Gutenberg University Mainz
2016-2020
Zimmer Biomet (Netherlands)
2019-2020
University Medical Center
2019-2020
University of Freiburg
2019-2020
Scripps Research Institute
2004-2016
Indian Institute of Technology Madras
2013
Bristol-Myers Squibb (United States)
2008-2010
Hematology Oncology Associates
2009-2010
PURPOSE To evaluate the efficacy of cetuximab plus taxane/carboplatin (TC) as first-line treatment advanced non-small-cell lung cancer (NSCLC). PATIENTS AND METHODS This multicenter, open-label, phase III study enrolled 676 chemotherapy-naïve patients with stage IIIB (pleural effusion) or IV NSCLC, without restrictions by histology epidermal growth factor receptor expression. Patients were randomly assigned to cetuximab/TC TC. TC consisted paclitaxel (225 mg/m(2)) docetaxel (75 mg/m(2)), at...
Abstract Brain metastases are among the most feared complications in breast cancer, as no therapy exists that prevents or eliminates cancer spreading to brain. New therapeutic strategies depend on specific knowledge of tumor cell properties allow growth within brain tissue. To provide information this direction, we established a human model for metastasis based circulating cells from patient and variants these derived bone lesions immunodeficient mice. The brain-derived showed an increased...
PURPOSE The anti-epidermal growth factor receptor (EGFR) antibody cetuximab is efficacious in multiple tumor types. Patient selection with markers predictive of benefit may enhance its therapeutic index. This retrospective, correlative analysis the phase III trial BMS099 advanced non-small-cell lung cancer (NSCLC) was conducted to identify molecular for patients most likely from cetuximab. METHODS In BMS099, 676 chemotherapy-naïve stage IIIB (pleural effusion) or IV NSCLC any histology EGFR...
To evaluate the efficacy of cetuximab added to first-line gemcitabine/platinum in chemotherapy-naïve patients with advanced non-small-cell lung cancer (NSCLC).In this noncomparative, randomized trial, recurrent/metastatic NSCLC (stage IV or stage IIIB malignant pleural effusion) were eligible. Patients received cisplatin (75 mg/m2 i.v., every 3 weeks) carboplatin (area under concentration-versus-time curve 5 intravenously [i.v.], weeks), and gemcitabine (1,250 1,000 days 1 8) plus (400 i.v....
Purpose To determine the dose of cetuximab that can be safely combined with irinotecan for treatment pediatric and adolescent patients refractory solid tumors. Patients Methods This open-label, phase I study enrolled ages 1 to 18 years advanced tumors, including tumors CNS. Patient cohorts by age group (children, 12 years; adolescents, 13 years) received escalating weekly doses (75, 150, 250 mg/m 2 ) in a 3 + design, plus (16 or 20 /d) 5 days consecutive weeks every 21 days. The primary end...
Combinatorial antibody libraries have the potential to display entire immunological record of an individual, allowing one detect and recover any ever made, irrespective whether it is currently being produced. We termed this “fossil record” individual's response. To determine cancer patients made antibodies with disease-fighting potential, we screened combinatorial from for immunoglobulins that can identify metastatic tumor cells. This strategy yielded human specific activated conformation...
The first part of this article is a brief survey the properties so-called almost interior points in ordered Banach spaces. Those vectors can be seen as generalisation "functions which are strictly positive everywhere" on $L^p$-spaces
Abstract Purpose. To determine the optimal dose of antiepidermal growth factor receptor (EGFR) monoclonal antibody cetuximab that can be safely administered in combination with a standard daily erlotinib patients advanced solid malignancies. Patients and Methods. malignancies who had failed chemotherapies received escalating doses without loading (100, 200, 250 mg/m2 i.v. weekly) fixed (150 mg orally) until disease progression or unacceptable toxicity. Results. Twenty-two were treated,...
8021 Background: This phase III study investigated cetuximab (C) plus taxane/carboplatin (TC) in 1 st -line advanced NSCLC. Progression-free survival (PFS) was not significantly different with the addition of C to TC; response rate (RR) higher; median overall (OS) longer, a difference (not statistically significant) similar magnitude significant OS improvement from FLEX (cisplat/vinorelb±C). Potential patient-selection markers were analyzed, including mut K-Ras, EGFR and gene copy number...
7539 Background: This randomized phase II study was conducted to evaluate the benefit of adding cetuximab, an IgG1 monoclonal antibody targeting EGF receptor, gemcitabine/platinum chemotherapy in patients with recurrent or metastatic NSCLC. Methods: Patients previously untreated stage IIIB (malignant pleural effusion) IV NSCLC irrespective their receptor status were eligible for this study. on arm A received cetuximab (400 mg/m 2 day 1 followed by 250 weekly) combined either cisplatin (75 q3...
Abstract Background The ERANet-LAC CODE (Care Of the Dying Evaluation) international survey assessed quality of care for dying cancer patients in seven countries, by use i-CODE questionnaire completed bereaved relatives. aim this sub study was to explore which factors improve or reduce end-of-life (EOL) from Norwegian relatives’ point view, as expressed free text comments. Methods 194 relatives hospitals 6–8 weeks after bereavement; recruitment period 14 months; response rate 58%. Responders...
Abstract In Archimedean vector lattices we show that each element of the band generated by a finite is also finite. with (PPP) and in Banach obtain some characterizations elements using generalized order units for principal bands. case continuous norm ideal all coincides linear span atoms. Some other related results applications are included. (© 2006 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Abstract Let E be a Banach lattice. H stand for sublattice, an ideal or band in , and denote by Φ 1 ( ) the ideals of finite elements vector lattices respectively. In this paper we first present some sufficient conditions counterexamples inclusions ⊂ ∩ to hold not. For closed (and therefore bands) there always holds ). If is projection then even P = It proved that every element also both its Dedekind completion Ê bidual space ″. Some results concerning direct sums are included. (© 2007...