A5011494265- Sarcoma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Ear and Head Tumors
- Musculoskeletal synovial abnormalities and treatments
- Protein Degradation and Inhibitors
- Ocular Oncology and Treatments
- Cancer Genomics and Diagnostics
- Lymphoma Diagnosis and Treatment
- CAR-T cell therapy research
- Testicular diseases and treatments
- Cutaneous Melanoma Detection and Management
- Renal and related cancers
- Bone Tumor Diagnosis and Treatments
- Tumors and Oncological Cases
- Cancer therapeutics and mechanisms
- Gastrointestinal Tumor Research and Treatment
- Ovarian cancer diagnosis and treatment
- Neuroendocrine Tumor Research Advances
- Lung Cancer Treatments and Mutations
- Intraperitoneal and Appendiceal Malignancies
- Cardiac tumors and thrombi
- Hepatocellular Carcinoma Treatment and Prognosis
- Vascular Tumors and Angiosarcomas
- Immunotherapy and Immune Responses
- Soft tissue tumors and treatment
The University of Texas MD Anderson Cancer Center
2016-2025
Zealand University Hospital Køge
2020
Museum of Fine Arts, Houston
2017
Pediatrics and Genetics
2011-2015
National Cancer Institute
2010-2015
Cairo University
2015
The University of Texas at Austin
2005-2013
The University of Sydney
2012
La Roche College
2010
Memorial Sloan Kettering Cancer Center
2009-2010
To determine whether consolidation therapy with high-dose melphalan, etoposide, and total-body irradiation (TBI) autologous stem-cell support would improve the prognosis for patients newly diagnosed metastatic Ewing's sarcoma (ES).Thirty-two eligible ES to bone and/or marrow were enrolled onto this study. Treatment was initially comprised of five cycles induction chemotherapy (cyclophosphamide, doxorubicin, vincristine alternating ifosfamide etoposide) local control. Peripheral-blood...
Abstract Purpose: Desmoplastic small round cell tumor (DSRCT), which harbors EWSR1-WT1 t(11;22)(p13:q12) chromosomal translocation, is an aggressive malignancy that typically presents as intra-abdominal sarcomatosis in young males. Given its rarity, optimal treatment has not been defined. Experimental Design: We conducted a retrospective study of 187 patients with DSRCT treated at MD Anderson Cancer Center over 2 decades. Univariate and multivariate regression analyses were performed....
To review the outcome for all patients with ovarian dysgerminoma treated at M.D. Anderson Cancer Center who received bleomycin, etoposide, and cisplatin (BEP) to assess menstrual reproductive function of those conservative treatment.Clinical information was abstracted from medical record. Patients completed a detailed questionnaire about function; did not return were interviewed by telephone.Twenty-six identified as having been BEP chemotherapy pure January 1984 1998. Their median age 19.5...
Background: There are few data describing symptom prevalence in children with cancer. The available literature suggests that similar to adults, and distress high communication regarding end-of-life care needs is limited. Objectives: We evaluated prevalence, treatment recommendations, about issues for seen pediatric palliative consultation (PCC) at one National Cancer Institute-designated comprehensive cancer center. goal of our study was obtain baseline target areas need intervention....
Abstract Background Robatumumab (19D12; MK‐7454 otherwise known as SCH717454) is a fully human antibody that binds to and inhibits insulin‐like growth factor receptor‐1 (IGF‐1R). This multiinstitutional study (P04720) determined the safety clinical efficacy of robatumumab in three separate patient groups with resectable osteosarcoma metastases (Group 1), unresectable 2), Ewing sarcoma 3). Procedure infusions were administered every 2 weeks well tolerated minimal toxicity. Centrally reviewed...
The aim of this study was to determine the influence age on outcome in pediatric melanoma patients and identify factors associated with positive lymph node status population.A retrospective review a prospective database, using sentinel biopsy (SLNB), from 1992 2006, identified 109 primary diagnosis melanoma. Patient dichotomized as prepubescent (<10 years age) adolescent (≥10-18 age). Factors investigated included patient race, sex, tumor thickness, Spitzoid or Non-Spitzoid histology, radial...
There are currently no United States Food and Drug Administration approved molecularly matched therapies for sarcomas except gastrointestinal stromal tumors. Complicating this is the extreme diversity, heterogeneity, rarity of these neoplasms. Few therapeutic options exist relapsed refractory sarcomas. In clinical practice many oncologists refer patients genomic profiling hoping guidance on treatment after standard therapy. However, a systematic analysis actionable mutations has yet to be...
Local recurrence in Ewing sarcoma is associated with a poor prognosis. The purpose of the study was to determine factors that predict local after surgical treatment primary tumor.Between 1990 and 2001, 64 patients underwent resection sarcoma. Surgical margins were assessed histologically radiologically. Response preoperative chemotherapy determined by detailed specimen mapping. recurrence-free survival (LRFS) calculated Kaplan-Meier analysis. Multivariate analysis performed Cox proportional...
Multidrug resistance (MDR) mediated by high levels of mdr-1 (also known as PGY1)/P-glycoprotein (Pgp) has been studied in tissue culture systems; however, most tumor samples which express mdr-1/Pgp have much lower levels.We wanted to determine if seen clinically could be detected commonly used methods and these conferred MDR reversible Pgp antagonists.We multi-drug-resistant cell lines sublines with expression comparable those clinically. We evaluated the RNA Northern blot analysis, slot...
Abstract Purpose: Heat shock protein 90 (Hsp90) is essential for the posttranslational control of many regulators cell growth, differentiation, and apoptosis. 17-N-Allylamino-17-demethoxygeldanamycin (17-AAG) binds to Hsp90 alters levels proteins regulated by Hsp90. We conducted a phase I trial 17-AAG in pediatric patients with recurrent or refractory neuroblastoma, Ewing's sarcoma, osteosarcoma, desmoplastic small round tumor determine maximum tolerated dose, define toxicity pharmacokinetic...
Cutaneous melanoma in childhood is rare; therefore, its prognostic factors and biologic behavior the effectiveness of adjuvant diagnostic techniques this group remain mostly unknown.The authors conducted a retrospective, observational study on significance clinical pathologic findings from 137 cutaneous mucosal melanomas patients aged <18 years that were reviewed by pathology department large cancer center during period 1992 to 2006.Univariate analysis indicated there was significantly...
Purpose This non-randomized, patient-access protocol, assessed both safety and efficacy outcomes following liposomal muramyl-tripeptide-phosphatidylethanolamine (L-MTP-PE; mifamurtide) in patients with high-risk, recurrent and/or metastatic osteosarcoma. Methods Patients received mifamurtide 2 mg/m2 intravenously twice-weekly ×12 weeks, then weekly ×24 weeks without chemotherapy. Serum concentration-time profiles were collected. Adverse events within 24 hours of drug administration...
Background Increasing evidence suggests that lymphocyte recovery plays a major part in tumor control. Facilitating immune reconstitution might be novel direction of cancer therapy. The purpose this study was to determine if early is an independent prognostic indicator for high-risk Ewing sarcoma outcome. Results Data 24 patients were analyzed (age, 3 50 y; median, 16.5; male female, 16:8). 5-year overall survival (OS) the total population 47.9% [10.6 standard error (SE)]. Patients separated...
Chemotherapy during radiation and/or bone-seeking radioisotope therapy (153-samarium; 1 mCi/kg) may improve osteosarcoma cancer control.We analyzed our preliminary experience in high-risk, metastatic, recurrent patients a consecutive period of 20 months (May 2005-December 2006).Thirty-nine high-risk had radiotherapy; 119 sites were irradiated. A median four irradiated per patient (range 1-14). The dose and number fractions was 30 Gy 10 10-70 4-35 fractions). Chemotherapy, most commonly...
Background: Pediatric papillary thyroid cancer (PTC) typically presents with more advanced disease as compared adults, yet the prognosis, even in presence of distant metastatic disease, is usually excellent. Systemic therapies other than radioactive iodine (RAI) are rarely required. Sorafenib an orally administered multi-kinase inhibitor that has shown promise treatment adults cancer, but it not been studied children this disease. Objective: Our objective to present adolescent a progressive...