A5017606693- Forensic Toxicology and Drug Analysis
- Opioid Use Disorder Treatment
- Pharmaceutical and Antibiotic Environmental Impacts
- Analytical Chemistry and Chromatography
- Mass Spectrometry Techniques and Applications
- HIV, Drug Use, Sexual Risk
- Psychedelics and Drug Studies
- Alcohol Consumption and Health Effects
- Cannabis and Cannabinoid Research
- Research in Social Sciences
- Pain Management and Opioid Use
- SARS-CoV-2 detection and testing
- Analytical chemistry methods development
- Pesticide Residue Analysis and Safety
- Analytical Methods in Pharmaceuticals
- Substance Abuse Treatment and Outcomes
- Neurotransmitter Receptor Influence on Behavior
- Metabolomics and Mass Spectrometry Studies
- Prenatal Substance Exposure Effects
- Healthcare and Environmental Waste Management
- Homelessness and Social Issues
- Biosensors and Analytical Detection
- European and International Law Studies
- Alcoholism and Thiamine Deficiency
- Nausea and vomiting management
Finnish Institute for Health and Welfare
2016-2025
National Institutes of Health
2010-2014
Institute for Molecular Medicine Finland
2005-2009
Finnish Foundation for Alcohol Studies
2004
Abstract Background and aims Wastewater‐based epidemiology is an additional indicator of drug use that gaining reliability to complement the current established panel indicators. The this study were to: (i) assess spatial temporal trends population‐normalized mass loads benzoylecgonine, amphetamine, methamphetamine 3,4‐methylenedioxymethamphetamine (MDMA) in raw wastewater over 7 years (2011–17); (ii) address overall by estimating average number combined doses consumed per day each city;...
Wastewater-based surveillance of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is used to monitor population-level prevalence COVID-19 disease. In many cases, due lockdowns or analytical delays, analysis wastewater samples might only be possible after prolonged storage. this study, effect storage conditions on RNA copy numbers SARS-CoV-2 virus in influent was studied and compared persistence norovirus over time at 4 °C, −20 −75 °C using reverse-transcription quantitative...
Nine different oral fluid (OF) collection devices were studied to evaluate their suitability for collecting samples drug analysis. The Greiner Bio-One, Orasure Intercept, Immunalysis Quantisal, StatSure Saliva.Sampler, Cozart, Sarstedt Salivette, Malvern Medical OraCol, Acro Biotech Salicule, and Varian OraTube. For comparison, OF was also collected into plastic tubes. volume of quantified both in vitro from volunteers. Drug recovery by fortified at 1000 ng/mL with amphetamine,...
In recent years, the interest in use of oral fluid as a biological matrix has increased significantly, particularly for detecting driving under influence drugs (DUID). this study, relationship between and blood concentrations abuse drivers suspected DUID is discussed. Blood samples were collected from or stopped during random controls by police Belgium, Germany, Finland, Norway ROSITA-2 project. The analyzed gas chromatography-mass spectrometry (GC-MS) liquid (LC-MS), sometimes preceded...
Abstract An analytical procedure was developed for the simultaneous sensitive identification, screening and quantitation of 30 drugs abuse using 250 µl human oral fluid. The method employs sequential mixed‐mode solid‐phase extraction (SPE), optimized derivative formation long‐column fast gas chromatography/electron impact mass spectrometry (GC/EI‐MS). After SPE elution, most stable derivatives were formed by taking careful account characteristics active functional groups possible steric...
Wastewater-based epidemiology is an efficient way to assess illicit drug use, complementing currently used methods retrieved from different data sources. The aim of this study compare stimulant use in five Nordic capital cities that include for the first time wastewater samples Torshavn Faroe Islands. Currently there are no published reports these capitals. All were analyzed using solid phase extraction and ultra-high performance liquid chromatography coupled tandem mass spectrometry....
Fast gas chromatography/negative-ion chemical ionization mass spectrometric (GC/NICI-MS) assay combined with rapid and nonlaborious sample preparation is presented for the simultaneous determination of benzodiazepines alpha-hydroxy metabolites, zaleplon zopiclone in whole blood. The compounds were extracted from 100 microl blood by multitube, microscale liquid-liquid extraction (LLE) derivatized N-methyl-N-(tert-butyldimethylsilyl)trifluoroacetamide (MTBSTFA), without need time-consuming...
Illicit drug use presents a significant challenge to global health and public safety, requiring innovative effective monitoring strategies. This study aimed evaluate the current landscape of wastewater-based epidemiology (WBE) for illicit drugs in Europe, focusing on collaboration, practices, barriers, while identifying opportunities improvement. Cross-sectional survey-based study. Coordinated by Sewage Analysis CORe Group Europe (SCORE) European Union Drugs Agency (EUDA), two surveys were...
Injecting drug use is a matter of public health concern, associated with risks overdoses, addiction and increased risk bloodborne viral transmissions. Self-reported data on substances injected can be inaccurate or subject to bias users might oblivious their adulterations. Gathering robust analytical information the actual composition provide better about drugs that are being used. Therefore, this study aimed analyse residual content discarded syringes collected across 7 European cities,...
This study investigated amphetamine concentrations in both oral fluid and whole blood samples of persons suspected driving under the influence drugs. The data for were obtained from 153 cases. mean volume collected with Intercept® collection device was 224 µL. Because small sample fluid, results not used calculations 39 total number cases positive 100 out 114. In seven (cutoff 25 µg/L), even though negative 20 µg/L). All found (n = 93) also fluid. Oral would therefore be well suited as a...
Abstract Background Prenatal alcohol exposure (PAE) is one of the leading causes preventable developmental disabilities. A lack objective screening methods results in an under‐recognition phenomenon. Phosphatidylethanol (PEth) a specific ethanol biomarker that reveals intake up to several weeks after use. So far, PEth has mostly been tool for detecting moderate and heavy drinking. With lower cut‐offs, revealing even minor prenatal consumption possible. We aimed find out if sensitive method...
Abstract Background Despite reporting lower levels of alcohol consumption, people with socio-economic status (SES) experience greater alcohol-related harm. Whether differential biases in the measurement use could explain this apparent paradox is unknown. Using biomarkers to account for error, we examined whether exposure differences mortality. Methods Participants from eight representative health surveys (n = 52 164, mean age 47.7 years) were linked mortality data and followed up until...
Abstract Wastewater-based surveillance of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is used to monitor population-level prevalence COVID-19 disease. In many cases, due lockdowns or analytical delays, analysis wastewater samples might only be possible after prolonged storage. this study, effect storage conditions on RNA copy numbers SARS-CoV-2 virus in influent was studied and compared persistence norovirus over time at 4°C, −20°C, −75°C using reverse-transcription...
A toxicological analysis was developed and validated for simultaneous screening quantification of methadone (METH) its primary metabolite 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP). The method employs microscale liquid-liquid extraction (microLLE) direct injection a separated aliquot the organic layer into gas chromatography/mass spectrometric (GC/MS) system without any other pre-treatment stages. fast GC/MS runtime (total 5.8 min; METH, Rt = 3.55 EDDP, 3.40 min) combined with...