A5056597436- Bone Metabolism and Diseases
- Bone health and treatments
- Bone health and osteoporosis research
- Wnt/β-catenin signaling in development and cancer
- Cytokine Signaling Pathways and Interactions
- Iron Metabolism and Disorders
- Bone and Joint Diseases
- MicroRNA in disease regulation
- Hemoglobinopathies and Related Disorders
- Acute Myeloid Leukemia Research
- Parathyroid Disorders and Treatments
- Estrogen and related hormone effects
- Thyroid Disorders and Treatments
- Trace Elements in Health
- Cancer, Lipids, and Metabolism
- Erythrocyte Function and Pathophysiology
- Vitamin D Research Studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Erythropoietin and Anemia Treatment
- Bone and Dental Protein Studies
- Radiopharmaceutical Chemistry and Applications
- Prostate Cancer Treatment and Research
- Adipose Tissue and Metabolism
- Proteoglycans and glycosaminoglycans research
- Connective tissue disorders research
Technische Universität Dresden
2016-2025
University of Zurich
2024
University Hospital Carl Gustav Carus
2013-2024
Group Health Cooperative
2022-2024
Royal Osteoporosis Society
2024
German Cancer Research Center
2017-2022
Deutschen Konsortium für Translationale Krebsforschung
2021-2022
Heidelberg University
2017-2021
Klinik und Poliklinik für Psychotherapie und Psychosomatik
2012-2021
Helmholtz-Zentrum Dresden-Rossendorf
2021
ROS are implicated in bone diseases. NADPH oxidase 4 (NOX4), a constitutively active enzymatic source of ROS, may contribute to the development such disorders. Therefore, we studied role NOX4 homeostasis. Nox4(-/-) mice displayed higher density and reduced numbers markers osteoclasts. Ex vivo, differentiation monocytes into osteoclasts with RANKL M-CSF induced Nox4 expression. Loss activity attenuated osteoclastogenesis, which was accompanied by impaired activation RANKL-induced NFATc1...
Patients with diabetes mellitus have an impaired bone metabolism; however, the underlying mechanisms are poorly understood. Here, we analyzed impact of type 2 on physiology and regeneration using Zucker diabetic fatty (ZDF) rats, established rat model insulin-resistant mellitus. ZDF rats develop vascular complications when fed a Western diet. In 21-wk-old mineral density (BMD) was 22.5% (total) 54.6% (trabecular) lower at distal femur 17.2% 20.4% lumbar spine, respectively, compared...
Abstract Type 2 diabetes mellitus results in increased risk of fracture and delayed healing. ZDF fa/fa rats are an established model type with low bone mass We tested whether a sclerostin-neutralizing antibody (Scl-AbVI) would reverse the skeletal deficits diabetic rats. Femoral defects 3 mm were created 11-week-old nondiabetic +/+ stabilized by internal plate. Saline or 25 mg/kg Scl-AbVI was administered subcutaneously (s.c.) twice weekly for 12 weeks (n = 9–10/group). Bone strength...
Erythropoietin (EPO) primarily regulates red blood cell formation, and EPO serum levels are increased on hypoxic stress (e.g., anemia altitude). In addition to anemia, recent discoveries suggest new therapeutic indications for EPO, unrelated erythropoiesis. We investigated the skeletal role of using several models overexpression (Tg6 mice) administration (intermittent/continuous, high/low doses) in adult C57Bl6 female mice. Using microcomputed tomography, histology, markers, we found that...
Abstract The mevalonate pathway has emerged as a promising target for several solid tumors. Statins are inhibitors of the 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), rate-limiting enzyme this pathway, and commonly used to treat patients with hypercholesterolemia. Pleiotropic antitumor mechanisms statins have been demonstrated human cancer types. However, cells differ in their individual statin sensitivity some cell lines shown relative resistance. In study we demonstrate, that breast...
Thy-1 on mesenchymal stem cells promotes osteogenesis while inhibiting adipogenesis and obesity.
Activating internal tandem duplications (ITD) in the juxtamembrane domain of receptor tyrosine kinase FLT3 occur frequently patients with acute myeloid leukemia (AML). Constitutive active FLT3-ITD mutations induce aberrant signaling and promote leukemic cell transformation. Inactivation attenuating protein phosphatase CD45 (PTPRC) mice resulted development a severe hematopoietic phenotype characteristics AML. In addition, abnormal bone structures ectopic formation were observed these mice,...
Abstract WNT5A has recently been implicated in inflammatory processes, but its role as a bone marrow stromal cell (BMSC)–derived mediator of joint inflammation arthritis is unclear. Here, we investigated whether stimuli induce BMSC to control responses. levels were determined human after stimulation with lipopolysaccharide (LPS) or tumor necrosis factor α (TNF-α,) and synovial cells tissue patients rheumatoid (RA) TNF-α transgenic (hTNFtg) mice. A microarray analysis WNT5A-treated murine...