A5102966592- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- HIV/AIDS drug development and treatment
- Liver Disease and Transplantation
- Lung Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Cytomegalovirus and herpesvirus research
- Hepatitis Viruses Studies and Epidemiology
- Inertial Sensor and Navigation
- GNSS positioning and interference
- Radiomics and Machine Learning in Medical Imaging
- Pediatric Hepatobiliary Diseases and Treatments
- PARP inhibition in cancer therapy
- Virus-based gene therapy research
- Liver Diseases and Immunity
- Advanced Frequency and Time Standards
- Metallurgical Processes and Thermodynamics
- Wnt/β-catenin signaling in development and cancer
- Fungal Infections and Studies
- BRCA gene mutations in cancer
- Cancer, Hypoxia, and Metabolism
- Induction Heating and Inverter Technology
- Renal and related cancers
- Circular RNAs in diseases
Jiangsu University
2025
First People's Hospital of Kunshan
2025
Meteorological Bureau of Shenzhen Municipality
2024
Third Affiliated Hospital of Sun Yat-sen University
2011-2023
Sun Yat-sen University
2013-2023
The First Affiliated Hospital, Sun Yat-sen University
2017-2021
Objective:To analyze the efficacy and safety of entecavir (ETV) treatment for up to 5 years in nucleos(t)ide-naïve chronic hepatitis B patients real life.Methods: We retrospectively analyzed 230 nucleos(t)ide naïve who received ETV 0.5 mg/day monotherapy at least 3 months, whom 113 were HBeAg positive 117 negative.The primary endpoints was cumulative probability achieving a virological response (undetectable serum HBV DNA, <100IU/mL).Secondary rates ALT normalization (ALT < upper limit...
Background and aim Bile acid (BA) synthesis in the liver is regulated by Fibroblast Growth Factor 19 (FGF19) secreted from ileum as an enterohepatic feedback mechanism. Although FGF19 mRNA absent normal liver, gene expression was reported to increase response both extrahepatic intrahepatic cholestasis. The impact of upregulated on BA unclear overall role circulating under cholestatic conditions needs be further investigated. Methods directly quantified measuring serum concentrations...
Lipid metabolism is closely linked to uric acid metabolism, with previous studies suggesting associations between lipid profiles serum (SUA) levels. Apolipoprotein A1 (ApoA1), a key component in and transport, may also be associated SUA levels, though research this area remains limited. This study aimed investigate the independent association ApoA1 levels patients osteoporotic fractures (OPF). cross-sectional included 2,108 OPF admitted Kunshan Hospital, affiliated Jiangsu University, from...
Background and Objective . The direct-acting antiviral agents (DAAs) therapy has drastically improved the prognosis of hepatitis C virus (HCV) patients. However, viral drug resistance-associated variants (RAVs) can limit efficacy DAAs. For HCV-6a is not predominant prevalent genotype; data on prevalence naturally occurring RAVs in it scarce. Our study aims to assess treatment-naive Methods Nested PCR assays were performed 95 patients amplify HCV regions NS3, NS5A, NS5B. Results In NS3/4A...
Objectives . To compare entecavir (ETV) and tenofovir disoproxil fumarate (TDF) effects in chronic hepatitis B (CHB) patients with high HBV DNA. Method 96 treated initially (TDF group) or (ETV were included this retrospective study. The following parameters assessed: HBeAg e antibody (anti-HBe) status, serum alanine aminotransferase (ALT), HBV-DNA levels at weeks 4, 12, 24, 36, 48, 60, 72, 96; time to ALT normalization, undetectable levels, seroconversion; total duration of follow-up adverse...
To investigate the safety and efficacy of double plasma molecular adsorption system (DPMAS) with sequential low-dose exchange (LPE) in treating early hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF).Clinical data patients HBV-ACLF were prospectively collected, including a DPMAS LPE (DPMAS+LPE) group those standard medical treatment (SMT) group. The primary endpoint was death or transplantation (LT) at 12 weeks follow-up. Propensity-score matching performed to control...
Background . Prediction of HBsAg seroclearance, defined as the loss circulating with or without development antibodies for in patients chronic hepatitis B (CHB), is highly difficult and challenging due to its low incidence. This study aimed at developing validating a nomogram prediction CHB patients. Methods We analyzed total 1398 CHB. Two-thirds were randomly assigned training set (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"...
The inappropriate cessation of nucleos(t)ide analog (NA) therapy may lead to acute exacerbations chronic hepatitis B virus (HBV) infection, acute-on-chronic liver failure (ACLF), and even death. This study aims elucidate the association between NA prognosis in patients with HBV-ACLF. A total 901 ACLF were enrolled stratified into non-NA group. Clinical characteristics two groups compared. HBV-ACLF was evaluated using Cox proportional hazard models after propensity score matching (PSM)....
To evaluate the consequences of lamivudine withdrawal in kidney transplant recipients, under immunosuppression, with inactive hepatitis B virus (HBV) infection.HBV infection is more frequent recipients than general population mainly due to high risk acquisition during dialysis, before transplantation.The records surface antigen (HBsAg)-positive, immunosuppressed where was withdrawn after transplantation along reduction immunosuppressant dose, admitted our hospital between 2005 and 2012, were...
The association between serum hepatitis C virus (HCV) load and hepatic injury in HCV-infected patients has been extensively investigated. present study aimed to investigate the HCV parenchyma cells patients. A total of 56 were included retrospective study. mRNA was determined using quantitative polymerase chain reaction, while cell volume also determined. Hepatic evaluated on basis severity inflammation fibrosis. results demonstrated that there evident differences mean RNA levels...
Objectives The optimal treatment of hepatitis C virus (HCV) genotype 6 is unclear owing to its limited geographic distribution. Because a high predictive value rapid virological response (RVR) for sustained (SVR), we conducted an open-label randomized controlled trial compare 24- and 48-week peginterferon/ribavirin combination therapy patients with HCV in Southern China who achieved RVR. Methods Findings Treatment-naive, non-cirrhotic chronic were treated pegylated interferon α-2a (180...
To evaluate the efficacy and safety of tenofovir disoproxil fumarate (TDF) in patients with chronic hepatitis B (CHB) after failure nucleoside-analogues (NAs).A total 30 CHB who had been previously treated NAs subsequently completed a 48-week course TDF were retrospectively investigated. Patients' data HBV DNA level (log10 copies/ml) rate undetectable at treatment weeks 0 (baseline), 4, 12, 24, 36 48 collected for evaluation. The lower limit detection was 100 IU/ml. serum alanine...
Wastewater-based epidemiology (WBE) is an emerging discipline, which has been applied to drug abuse tracking and infectious disease pathogen surveillance. During the COVID-19 epidemic, WBE monitor epidemic trend SARS-CoV-2 variants etc. In order detect hidden cases prevent transmission in community, wastewater surveillance system for monitoring RNA was developed Shenzhen. The sewage sampling sites were set up key places such as port areas, urban villages residential communities of Futian,...
Many patients had to transfer tenofovir disoproxil fumarate (TDF) if there is other nucleos(t)ide analogue (NA) resistance. We aimed investigate antiviral effects of TDF monotherapy between NA-naive and NA-experienced chronic hepatitis B (CHB) in China.A total 102 CHB with (300 mg/day) were retrospectively analyzed for useful parameters up 72 weeks.There 36 66 matched HBV DNA baseline level NA-naïve group, respectively. There no significant differences groups levels (all P > 0.05)...
Background: The objective of this study is to analyze the causes nontreatment among patients with hepatitis C virus (HCV) infection and increase cure rate chronic in Guangdong Province. Methods:We performed both retrospective survey prospective a cohort 435 outpatients our center subjective HCV non-treatment.Results: Among 1,931 patients, did not receive anti-viral therapy (AVT), and, 37 these load was persistently negative.In remaining 398 RNA repeatedly tested positive.The included...
To investigate the safety and efficacy of direct-acting antiviral (DAA) regimens in a cohort Chinese patients with chronic hepatitis C virus (HCV) infection. A total 222 adult were enrolled treated via DAA accordance HCV management guidelines. Treatment responses evaluated 4 weeks after treatment, at end treatment (EOT) 12 post-treatment. Virological responses, biochemical model for end-stage liver disease (MELD) Child-Pugh (CP) scores recorded. 218 (98.2%) achieved sustained virological...
The aim of this study was to evaluate the efficacy and safety entecavir (ETV) combined treatment with adefovir (ADV) on chronic hepatitic B (CHB) patients who failed respond nucleotide (acid) analog (NA) treatment. On basis, possible factors in these will be analyzed. safety, biochemical index, that might affect ETV ADV at different points time were retrospectively index included following: virological response, hepatitis virus (HBV) DNA decline, primary nonresponse, E antigen/hepatitis...
In the present study, efficacy and safety of tenofovir disoproxil fumarate (TDF) switch therapy were assessed in patients with chronic hepatitis B exhibiting a suboptimal response to adefovir (ADV)‑based combination therapy. First, TDF was retrospectively evaluated 50 who failed respond ADV‑based treatment. Among those, 48 median age 35 years e antigen (HBeAg)‑positive 17, 14 19 previously treated lamivudine (LAM) plus ADV, telbivudine ADV entecavir (ETV) respectively. A total 41 alone 9...