A5036569805- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Mesenchymal stem cell research
- COVID-19 Clinical Research Studies
- Liver physiology and pathology
- SARS-CoV-2 and COVID-19 Research
- Immune Cell Function and Interaction
- Viral gastroenteritis research and epidemiology
- Ferroptosis and cancer prognosis
- Hepatocellular Carcinoma Treatment and Prognosis
- Drug Transport and Resistance Mechanisms
- Acupuncture Treatment Research Studies
- Pharmacological Effects of Natural Compounds
- MicroRNA in disease regulation
- Hepatitis Viruses Studies and Epidemiology
- RNA modifications and cancer
- Long-Term Effects of COVID-19
- Epigenetics and DNA Methylation
- Drug-Induced Hepatotoxicity and Protection
- Clinical Nutrition and Gastroenterology
- COVID-19 diagnosis using AI
- Pancreatic and Hepatic Oncology Research
Third Affiliated Hospital of Sun Yat-sen University
2016-2025
Sun Yat-sen University
2016-2025
Chinese Academy of Tropical Agricultural Sciences
2025
Ministry of Agriculture and Rural Affairs
2025
Guiyang Medical University
2023-2024
Yantaishan Hospital
2024
University of South China
2024
National University of Defense Technology
2023
Key Laboratory of Guangdong Province
2022
Ministry of Education of the People's Republic of China
2022
Abstract Purpose The purpose of this study was to detect severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) ribonucleic acid (RNA) in urine and blood specimens, anal oropharyngeal swabs from patients with confirmed SARS‐CoV‐2 infection, correlated positive results clinical findings. Methods Patients infections were included study. Patients' demographic data recorded. Quantitative real‐time polymerase chain reaction used RNA swabs. is registered at ClinicalTrials.gov (No....
Our study aimed to investigate the short-term efficacy and long-term prognosis of liver failure patients caused by hepatitis B after a single transplantation with autologous marrow mesenchymal stem cells (MMSCs). A total 527 inpatients were recruited received same medical treatments, among whom 53 underwent MMSCs. 105 matched for age, sex, biochemical indexes, including alanine aminotransferase (ALT), albumin, bilirubin (TBIL), prothrombin time (PT), Model End-Stage Liver Disease (MELD),...
Mortality from hepatitis B virus (HBV)–related acute‐on‐chronic liver failure (ACLF) is high due to limited treatment options. Preclinical and clinical investigations have proved that with mesenchymal stromal cells (MSCs) beneficial for recovery injury. We hypothesized the outcome of HBV‐related ACLF would be improved by MSC treatment. From 2010 2013, 110 patients were enrolled in this open‐label, nonblinded randomized controlled study. The control group (n = 54) was treated standard medical...
Abstract We tested samples collected from nine patients diagnosed with coronavirus disease 2019 (COVID-19). The virus was found in urine, blood, anal swabs and oropharyngeal swabs. It is the first time for SARS-CoV-2 though no urinary irritation found.
Mesenchymal stromal cells (MSCs) can differentiate to various cell types including osteoblasts, chondrocytes, and adipocytes. This cellular flexibility contributes widespread clinical use of MSCs in tissue repair. However, challenges remain efficient expansion for stem therapy. Current MSC culture methods have resulted reduced self-renewal compromised therapeutic outcomes. study identifies that nicotinamide mononucleotide (NMN), a key natural NAD+ intermediate, effectively encourages vitro...
SARS-CoV-2, the causative agent for COVID-19, infect human mainly via respiratory tract, which is heavily inhabited by local microbiota. However, interaction between SARS-CoV-2 and nasopharyngeal microbiota, association with metabolome has not been well characterized. Here, metabolomic analysis of blood, urine, swabs from a group COVID-19 non-COVID-19 patients, metagenomic pharyngeal samples were used to identify key features COVID-19. Results showed lactic acid, l-proline, chlorogenic acid...
Abstract Ribosome biogenesis (RiboSis) and ribosomal stress are critical in tumor progression, positioning RiboSis as a promising therapeutic target for cancer treatment overcoming drug resistance. In this study, we examined the role of progression from hepatitis B virus (HBV) infection to HBV-related hepatocellular carcinoma (HCC), focusing specifically on nucleolar protein 9 (NOL9) its influence HCC pathogenesis response. Our findings showed that NOL9 was significantly upregulated tissues,...
In the past 50 years there have been considerable efforts to identify cellular receptor of hepatitis B virus (HBV). Recently, in vitro evidence from several groups has shown that sodium–taurocholate cotransporting polypeptide (NTCP, which is encoded by SLC10A1 and transports bile acids into hepatic cells enterohepatic recirculation) a strong candidate. particular, p.Ser267Phe variation results loss HBV function. We tested role NTCP as for chronic patients using genetic association study....
Background . Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is a common type of with high mortality. This study aimed at investigating the safety and efficacy combination treatment plasma exchange (PE) umbilical cord-derived mesenchymal stem cell (UC-MSCs) transplantation for HBV-ACLF patients. Methods A total 110 patients treated in our hospital from January 2012 to September 2017 were enrolled into this trial divided control group (<mml:math...
Abstract Hepatocellular carcinoma (HCC) is a severe disease with high mortality and global incidence. However, the interaction between gut microbiome combined immunotherapy for HCC yet unclear. In this prospective clinical study, patients unresectable who had not received systemic treatment previously were recruited. Fecal serum samples collected at baseline point before each subsequent administration as specified. Between 20 October 2019 2 February 2021, 61 screened eligibility, of whom 35...
Summary Background Hepatitis B surface antigen (HBsAg) seroclearance marks regression of hepatitis virus (HBV) infection. However, more than one‐fifth patients with functional cure following pegylated interferon‐based therapy may experience HBsAg seroreversion. The mechanisms causing the HBV relapse remain unclear. Aim To investigate level and origin transcripts in their role predicting relapse. Methods Liver tissue obtained from cure, as well uncured treatment‐naïve HBeAg‐negative chronic...
Since stem cells can differentiate into hepatocyte, cell-based therapy becomes a potential alternative treatment for terminal liver diseases. However, an appropriate source of human mesenchymal (hMSCs) hepatocytes has not yet been clearly elucidated. The aim the present study was to investigate in vitro biological characterization and hepatic differentiation amniotic fluid-derived (AF-hMSCs) bone marrow-derived (BM-hMSCs). Our results show that AF-hMSCs possess higher proliferation...
Chromobox (CBX) proteins are important components of epigenetic regulation complexes known to play key roles in hepatocellular carcinoma (HCC). Little is about the function distinct CBXs HCC. To address this issue, study investigated prognosis HCC using ONCOMINE, UALCAN, Human Protein Atlas, Kaplan-Meier Plotter, c-BioPortal databases. Over expressions 8 members were found be significantly associated with clinical cancer stages and pathological tumor grades patients. Besides, higher mRNA...
SLC10A1 codes for the sodium-taurocholate cotransporting polypeptide (NTCP), which is a hepatocellular transporter bile acids (BAs) and receptor hepatitis B D viruses. NTCP also target of multiple drugs. We aimed to evaluate medical consequences loss function mutation p.Ser267Phe in SLC10A1. identified eight individuals with homozygous followed up 8-90 months. compared their total serum BAs 6 species 170 wild-type 107 heterozygous healthy individuals. performed in-depth examinations exome...
Bone marrow-derived mesenchymal stem cells (BMSCs) can reduce liver fibrosis. Apart from the paracrine mechanism by which antifibrotic effects of BMSCs inhibit activated hepatic stellate (HSCs), direct interplay and juxtacrine signaling between two cell types are poorly understood. The purpose this study was to explore underlying mechanisms modulate function HSCs.We used directly indirectly co-culture system with HSCs evaluate anti-fibrosis effect BMSCs. Cell proliferation activation were...
Uncontrolled hepatic immunoactivation is regarded as the primary pathological mechanism of fulminant failure (FHF). The major acute-phase mediators associated with FHF, including IL-1β, IL-6, and TNF-α, impair regeneration liver cells stem cell grafts. Amniotic-fluid-derived mesenchymal (AF-MSCs) have capacity, under specific conditions, to differentiate into hepatocytes. Interleukin-1-receptor antagonist (IL-1Ra) plays an anti-inflammatory anti-apoptotic role in acute chronic inflammation,...
The La-related protein 1 (LARP1) has been found to be a RNA binding and was related spermatogenesis, embryogenesis cell-cycle progression. aim of this study investigate the prognostic value LARP1 in hepatocellular carcinoma (HCC). expression examined 15 HCC cell lines 272 clinical specimens using real-time PCR, immunohistochemistry (IHC) western blot analysis (WB). also studied 6 paired lesions adjacent non-cancerous tissue samples. Statistical analyses were applied derive association...
Current evidence suggests that the mortality rate of intermediate-stage hepatitis B virus (HBV)-related acute-on-chronic liver failure (ACLF) remains high. We aimed to investigate safety and efficacy double plasma molecular adsorption system (DPMAS) with sequential low-volume exchange (LPE) treatment in HBV-related ACLF. This prospective study recruited ACLF patients was registered on ClinicalTrials.gov (NCT04597164). Eligible were randomly divided into a trial group control group. Patients...
With the aging population and popularity of implant prostheses, an increasing number postmenopausal osteoporosis (PMOP) patients require restorations; however, poor bone condition affects long-term stability prostheses. This study aimed to investigate therapeutic effect quercetin (QR) compared with alendronate (ALN), primary treatment for PMOP, on mandibular (OP) induced by ovariectomy (OVX) in female rats. Adult rats were treated QR (50 mg/kg/day), ALN (6.25 mg/kg/week) gavage 8 weeks,...
Summary Background and Aims For chronic hepatitis B (CHB) patients, there is still a need to improve surface antigen (HBsAg) clearance rates. This study aimed assess the predictive effectiveness of soluble programmed cell death‐1 (sPD‐1) death ligand‐1 (sPD‐L1) for HBsAg in HBeAg‐negative CHB patients undergoing peginterferon (Peg‐IFN)‐based antiviral treatment. Methods encompassed 280 treatment with Peg‐IFNα. Serum levels sPD‐1 sPD‐L1 were measured using ELISA kits at baseline, as well 12,...