A5100374997- Gut microbiota and health
- Probiotics and Fermented Foods
- Clostridium difficile and Clostridium perfringens research
- Diet and metabolism studies
- Ovarian cancer diagnosis and treatment
- Reproductive Biology and Fertility
- Gastrointestinal motility and disorders
- Endometriosis Research and Treatment
- Sperm and Testicular Function
- Ginseng Biological Effects and Applications
- Neuroendocrine regulation and behavior
- Ovarian function and disorders
- Animal Nutrition and Physiology
- Pharmacological Effects of Natural Compounds
- Reproductive System and Pregnancy
- Endometrial and Cervical Cancer Treatments
- Colorectal Cancer Screening and Detection
- Reproductive Health and Technologies
- Metabolomics and Mass Spectrometry Studies
- Uterine Myomas and Treatments
- Helicobacter pylori-related gastroenterology studies
- Gynecological conditions and treatments
- Genomics and Phylogenetic Studies
- Liver Disease Diagnosis and Treatment
- Pediatric health and respiratory diseases
Hunan University of Traditional Chinese Medicine
2023-2025
Tianjin University of Commerce
2025
Tianjin University of Science and Technology
2024
Fujian Academy of Agricultural Sciences
2023-2024
Oklahoma State University
2020-2024
Weatherford College
2024
Cardiff University
2024
Guangdong Provincial People's Hospital
2023-2024
Jinan University
2023-2024
Hainan Normal University
2024
SARS-CoV-2, the causative agent for COVID-19, infect human mainly via respiratory tract, which is heavily inhabited by local microbiota. However, interaction between SARS-CoV-2 and nasopharyngeal microbiota, association with metabolome has not been well characterized. Here, metabolomic analysis of blood, urine, swabs from a group COVID-19 non-COVID-19 patients, metagenomic pharyngeal samples were used to identify key features COVID-19. Results showed lactic acid, l-proline, chlorogenic acid...
The interaction of gut content microbiota, brain peptides and lipid metabolism-related indicators leads to digestive dysfunction in mice, which may be one the mechanisms action fatigue factors combined with HFD-induced diarrhea.
Women suffer from various distress and disturbances after menopause, including osteoporosis, a risk factor associated with multiple diseases. Altered gut microbiota has been implicated in postmenopausal osteoporosis. In this study, to understand signatures fecal metabolite changes women 108 were recruited for intestinal detection. Among these participants, 98 patients, who met the inclusion criteria, divided into osteoporosis (PMO) non-postmenopausal (non-PMO) groups based on bone mineral...
Gut microbiota (GM) contributes to the production of immune-regulatory molecules and cytokines. However, our understanding regarding intricate relationship between Lactobacillus plantarum GM on regulation immune function remained limited. To investigate effect an immunosuppressed mouse model, we employed cyclophosphamide treatment conducted various analysis including H&E (hematoxylin-eosin staining), immunohistochemistry, 16S rRNA gene sequencing, RT-PCR. Our results demonstrated that...
Huoxiang Zhengqi San (HXZQS), a traditional Chinese herbal formula, enjoys widespread use in medicine to treat diarrhea with cold-dampness trapped spleen syndrome (CDSS), which is induced by exposure cold and high humidity stress. This study aimed explore its therapeutic mechanisms mice, particularly focusing on the intestinal microbiota. Forty male SPF-grade KM mice were allocated into two groups: normal control group (H-Cc, n = 10) CDSS (H-Mc, 30). After modeling, H-Mc was subdivided (n...
Zinc oxide nanoparticles (ZnO NPs) are used widely in consumer and industrial products, however, their influence on gut microbiota metabolism mutual interactions not fully understood. In this study, the effects of ZnO NPs ileal bacterial communities, plasma metabolites, correlations between them were investigated. Hens fed with different concentrations [based Zn; 0 mg/kg (control), 25 mg/kg, 50 100 mg/kg] for 9 weeks. Subsequently, digesta blood collected analysis microflora respectively....
Necrotic enteritis (NE), an economically devastating disease of poultry caused by pathogenic Clostridium perfringens , is known to induce small intestinal lesions and dysbiosis. However, the microbes that are associated with NE severity yet be characterized. Here, we investigated link between ileal microbiota in a chicken model clinical using 16S rRNA gene sequencing. Our results indicated richness Shannon Index were drastically reduced ( p <0.01) as was exacerbated. While relative...
The aim of this study was to investigate the protective effect alanyl-glutamine (Ala-Gln) on acute colitis complicated by pulmonary injury induced dextran sulfate sodium (DSS) in C57BL/6 mice. results showed that Ala-Gln intervention alleviated weight loss, disease activity index (DAI), colon shortening, and pathological regulated absolute number CD4+T-cell subsets mesenteric lymph nodes (MLNs). In addition, significantly ameliorated composition gut microbiota mice with DSS- colitis,...
Abstract Objective It was reported fatigue or a high-fat diet triggers diarrhea, and intestinal microbiota may play central roles in diarrhea. Therefore, we investigated the association between mucosal barrier from combined with diet. Method This study divided Specific pathogen-free (SPF) male mice into normal group (MCN) standing united lard (MSLD). The MSLD stood on water environment platform box for 4 h/day 14 days, 0.4 mL gavaged day 8, twice daily 7 days. Result After Mice showed...
Antibiotics used as a common clinical treatment have saved many lives. Widespread use of antibiotic therapy has been known to disrupt the balance pathogenic bacteria, host-associated microorganisms and environment. However, our understanding Bacillus licheniformis for health benefits ability restore ceftriaxone sodium-induced gut microbial dysbiosis is severely limited. We Caco-2 cell, H&E (hematoxylin-eosin staining), RT-PCR 16S rRNA sequencing techniques investigate influence on...
Density-dependence is an important mechanism in the population regulation of small mammals. Stressors induced by high-density (e.g., crowding and aggression) can cause physiological neurological disorders, are hypothesized to be associated with alterations gut microbiota, which may turn reduce fitness animals increasing stress- or disease-associated microbes. In this study, we examined effects housing density on hormone levels, immunity, composition microbiota male Brandt's voles...
Abstract Purpose Microorganisms are important in tobacco aging. These used to improve the quality of leaves after threshing and redrying. However, response microbial community storage environment time during aging process has been less explored. This study aimed characterize dynamic changes composition diversity leaf samples. Methods In this study, 16S ITS rRNA gene amplicon sequencing techniques were composition, diversity, co-occurrence stored two different cities 24-month Furthermore,...
Seasonal breeding in mammals has been widely recognized to be regulated by photoperiod, but the association of gut microbiota with photoperiodic regulation seasonal never investigated.In this study, we investigated photoperiod-induced reproduction male Brandt's voles (Lasiopodomys brandtii) through a long-day and short-day photoperiod manipulation experiment fecal transplantation (FMT) experiment. We found significantly altered reproductive hormone gene expression levels, voles. Specific...
Island vertebrates have evolved a number of morphological, physiological, and life history characteristics that set them apart from their mainland relatives. However, to date, the evolution metabolism its impact on vulnerability extinction insular remains poorly understood. This study used metabolic data 2813 species tetrapod vertebrates, including 695 ectothermic 2118 endothermic species, reveal island mammals birds convergent strategies toward slow pace life. Insularity was associated with...
The gastrointestinal (GI) tract harbors a diverse population of microorganisms. While much work has been focused on the characterization bacterial community, very little is known about fungal or mycobiota, in different animal species and chickens particular. Here, we characterized biogeography mycobiota along GI day 28 broiler chicks further examined its possible shift response to bacitracin methylene disalicylate (BMD), commonly used in-feed antibiotic, through Illumina sequencing internal...
Background: The gut is thought to play an important role in the pathogenesis of sepsis. Changes microbiota are closely related occurrence and development human diseases, but few studies have focused on taxonomic composition septic patients. Knowledge changes a key issue intensive care. Clinicians must understand how altered affects susceptibility prognosis Measurements Main Results: In single-center case control study, 20 patients healthy children were recruited. was determined via 16S rRNA...
The occurrence and development of type 2 diabetes mellitus (T2DM) are closely related to gut microbiota. Jiaotai pill (JTP) is used treat mellitus, with definite efficacy in clinical practice. However, it not clear whether the therapeutic effect produced by regulating changes microbiota its metabolism. In this study, T2DM rat models were established a high-fat diet low-dose streptozotocin (STZ). Based on pharmacodynamic evaluation, mechanism JTP treatment was investigated fecal metabolism...
Preliminary research finds that a high-fat diet (HFD) in fatigued state triggers diarrhea, but the exact mechanism has not been clarified. To address concerns about pathogenesis of study evaluates composition and metabolomics gut microbiota.The uses multiple platform apparatus device to induce fatigue mice, combined with intragastric administration lard-caused diarrhea. Subsequently, characteristics interaction relationship microbiota, short-chain fatty acids (SCFAs), inflammatory...
A recent study showed that patients with coronavirus disease 2019 (COVID-19) have gastrointestinal symptoms and intestinal flora dysbiosis. Yeast probiotics shape the gut microbiome improve immune homeostasis. In this study, an oral candidate of yeast-derived spike protein receptor-binding domain (RBD) fusion peptide displayed on surface yeast cell wall was generated. The toxicity efficacy administration were further performed in Institute Cancer Research (ICR) mice. No significant...
Abstract Background Neoadjuvant concurrent chemoradiotherapy (nCCRT) is a standard treatment for locally advanced rectal cancer (LARC). The gut microbiome may be reshaped by radiotherapy through its effects on microbial composition, mucosal immunity, and the systemic immune system. We sought to clarify dynamic, longitudinal changes in blood immunomodulators throughout nCCRT explore relationship of such with outcomes after nCCRT. Methods A total 39 patients LARC were recruited this study....
Soil microorganisms (SM) are primarily involved in organism degradation, plant nitrogen nutrient immobilization, host and oxidation. However, research on the effect of soil-derived Lysinibacillus intestinal microbiota spatial disparity mice is lacking. To test probiotic properties microorganisms, hemolysis test, molecular phylogenetic analysis, antibiotic sensitivity testing, serum biochemical assays 16S rRNA profiling were applied. The results showed that (LZS1 LZS2) was resistant to two...