A5028295974- Gut microbiota and health
- Inflammatory Bowel Disease
- Liver Disease Diagnosis and Treatment
- Microscopic Colitis
- Probiotics and Fermented Foods
- Alcohol Consumption and Health Effects
- Tea Polyphenols and Effects
- IL-33, ST2, and ILC Pathways
- Immune Cell Function and Interaction
- Eosinophilic Esophagitis
- Clostridium difficile and Clostridium perfringens research
- Helicobacter pylori-related gastroenterology studies
- Selenium in Biological Systems
- Digestive system and related health
- Lipid metabolism and disorders
- Phytoestrogen effects and research
- Immunotherapy and Immune Responses
- Ginkgo biloba and Cashew Applications
- Eosinophilic Disorders and Syndromes
- Cancer Immunotherapy and Biomarkers
- Gastrointestinal motility and disorders
- Autoimmune and Inflammatory Disorders
- Infant Nutrition and Health
- Cancer-related molecular mechanisms research
- Diet and metabolism studies
Shenyang Sport University
2025
China Medical University
2014-2025
First Hospital of China Medical University
2010-2022
University of Oklahoma Health Sciences Center
2010
Rutgers, The State University of New Jersey
2010
Rutgers New Jersey Medical School
2010
This study aimed to investigate the mechanism of probiotic VSL#3 in acute alcoholic intestinal injury, and evaluate effect VSL#3, glutamine,VSL#3+glutamine heat-killed therapy a rat model.Six- eight-week-old male wild-type rats were divided into seven groups. To establish alcohol liver disease model, received three doses corn starch dissolved PBS/40% administered intra-gastrically every 12 hours. Treatment groups an intra-gastric dose Glutamine, or VSL#3+Glutamine 30 minutes prior...
Background. The role of the Th17/Treg balance in development experimental colitis remains poorly understood. Methods. We exploited differential response BALB/c mice and C57BL/6 towards drinking water mediated by dextran sulfate sodium (DSS) challenge. Results. DSS-resistant were characterized low levels IFN- γ TNF- α but high IL-4, IL-6, IL-10, IL-17A, IL-17F, colon lamina propria mesenteric lymph node (MLN) CD4 + CD25 FoxP3 T cells when compared to mice. Collectively, these data indicate...
Background/Aims: Transplantation of mesenchymal stem cells (MSCs) has been shown to alleviate dextran sulfate sodium (DSS) -induced colitis through modulation transforming growth factor β (TGFβ) receptor signaling. However, the exact molecular mechanisms are not known. Methods: Here, we transplanted primary mouse MSCs or injected TGFβ1 into mice with DSS-induced colitis. Cells were purified by flow cytometry. Gene expression was analyzed RT-qPCR. Results: We found that significantly...
Aim: To evaluate the effect of Selenium-enriched Lactobacillus acidophilus (Se-enriched L. ) on dextran sulfate sodium (DSS)-induced colitis in mice. Methods: Mice were randomly divided into four groups: a control group, + Se-enriched chronic and group ( n = 10 each group). The mice sacrificed 26th day. disease activity index, survival rates, histological injury score determined. Cytokines produced by lamina propria lymphocytes (LPLs), selenium (Se) concentrations serum colon tissue mouse...
The aim of this study was to investigate the protective effect alanyl-glutamine (Ala-Gln) on acute colitis complicated by pulmonary injury induced dextran sulfate sodium (DSS) in C57BL/6 mice. results showed that Ala-Gln intervention alleviated weight loss, disease activity index (DAI), colon shortening, and pathological regulated absolute number CD4+T-cell subsets mesenteric lymph nodes (MLNs). In addition, significantly ameliorated composition gut microbiota mice with DSS- colitis,...
Inflammatory bowel disease (IBD) is a nonspecific inflammatory of the intestine that includes Crohn’s and ulcerative colitis. Because IBD difficult to heal easily relapses, it could worsen patient quality life increase economic burdens. Curcumin (CUR) bioactive component derived from rhizome turmeric (Curcuma longa). Many basic clinical studies have shown CUR can efficiently treat by decreasing activity proinflammatory cytokines communicating with transcription factors signaling molecules....
To investigate whether morin can reduce hepatic fibrosis by activating the NF-E2-related factor 2 (Nrf2) signaling pathway. Twenty male Sprague-Dawley rats were randomly divided into four groups: control group, carbon tetrachloride (CCl4) and + CCl4 group. Rats in both groups injected intraperitoneally with at a dose of mL/kg twice week. treated orally 50 mg/kg Control vehicle only At end-point 8 wk experimental period, serum AST, ALT, ALP measured, liver specimens obtained for pathological...
Tea polyphenols (TPs), naturally present in green tea, have a number of health benefits, such as alleviating hepatic injury. Acute alcoholic liver injury was induced C57BL/6 male mice by 40% ethanol gavage, and the were treated with distilled water or TPs drinking (4 g/L, 0.4%) for 8 weeks. The results demonstrated that intake alleviated acute modulated gut microbiota composition abundance. supplementation elevated abundance propionic acid, butyric acid valeric ethanol-gavaged mice....
To determine the effects of heat-killed VSL#3 (B. breve, B. longum and infantis; L. plantarum, bulgaricus, casei acidophilus; S. salivarius subsp. thermophilus) therapy in dextran sulfate sodium (DSS)-induced acute experimental colitis rats. Acute was induced rats by 5% DSS freely drink for seven days. Beginning on Day 8, underwent gavage once daily days with probiotic (0.6 g/kg/day), colonic damage evaluated histologically biochemically after gavage. Expression inflammatory related...
Interleukin‐ (IL‐) 33, a member of the IL‐1 cytokine family, is an important modulator immune system associated with several immune‐mediated diseases. IL‐33 was expressed in high level on epithelial cells intestinal tract. It suggested that plays potential role inflammatory bowel diseases (IBD). We investigated interleukin‐ 33 dextran sulphate sodium‐ (DSS‐) induced acute colitis mice using recombinant mouse protein (rIL‐33). found DSS‐induced aggravated by rIL‐33 treatment. rIL‐33‐treated...