A5054196722- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Hepatitis B Virus Studies
- SARS-CoV-2 and COVID-19 Research
- Drug-Induced Hepatotoxicity and Protection
- Immune Cell Function and Interaction
- Poisoning and overdose treatments
- Hearing, Cochlea, Tinnitus, Genetics
- Ferroptosis and cancer prognosis
- COVID-19 and healthcare impacts
- HIV/AIDS drug development and treatment
- Insects and Parasite Interactions
- Liver Disease and Transplantation
- Allergic Rhinitis and Sensitization
- COVID-19 diagnosis using AI
- Food Allergy and Anaphylaxis Research
- T-cell and B-cell Immunology
- Immune Response and Inflammation
- SARS-CoV-2 detection and testing
- Disaster Response and Management
- MicroRNA in disease regulation
- Viral Infections and Outbreaks Research
- HIV-related health complications and treatments
- Cancer, Lipids, and Metabolism
Southern University of Science and Technology
2020-2025
Fujian Medical University
2025
Ningde Normal University
2025
National Clinical Research Center for Digestive Diseases
2024
Shenzhen Third People’s Hospital
2020-2024
Nanjing Agricultural University
2023
Sun Yat-sen University
2010-2018
Third Affiliated Hospital of Sun Yat-sen University
2010-2018
Huazhong University of Science and Technology
2018
University of Tennessee Health Science Center
2006-2011
There is currently an outbreak of respiratory disease caused by a novel coronavirus. The virus has been named severe acute syndrome coronavirus 2 (SARS-CoV-2) and the it causes 2019 (COVID-19). More than 16% patients developed distress syndrome, fatality ratio was 1%–2%. No specific treatment reported. Herein, we examined effects favipiravir (FPV) versus lopinavir (LPV)/ritonavir (RTV) for COVID-19. Patients with laboratory-confirmed COVID-19 who received oral FPV (Day 1: 1600 mg twice...
Recent data on the coronavirus disease 2019 (COVID-19) outbreak caused by severe acute respiratory syndrome 2 (SARS-CoV-2) has begun to shine light impact of liver. But no studies date have systematically described liver test abnormalities in patients with COVID-19. We evaluated clinical characteristics COVID-19 abnormal results.Clinical records and laboratory results were obtained from 417 laboratory-confirmed who admitted only referral hospital Shenzhen, China January 11 February 21, 2020...
OBJECTIVE Patients with obesity are at increased risk of exacerbations from viral respiratory infections. However, the association severity coronavirus disease 2019 (COVID-19) is unclear. We examined this using data only referral hospital in Shenzhen, China. RESEARCH DESIGN AND METHODS A total 383 consecutively hospitalized patients COVID-19 admitted 11 January 2020 to 16 February and followed until 26 March Third People’s Hospital Shenzhen were included. Underweight was defined as a BMI...
Abstract Background The clinical characteristics of novel coronavirus disease (COVID‐2019) patients outside the epicenter Hubei Province are less understood. Methods We analyzed epidemiological and features all COVID‐2019 cases in only referral hospital Shenzhen City, China, from January 11, 2020, to February 6, followed until March 2020. Results Among 298 confirmed cases, 233 (81.5%) had been Hubei, while 42 (14%) did not have a clear travel history. Only 218 (73.15%) fever as initial...
The characteristics, significance and potential cause of positive SARS-CoV-2 diagnoses in recovered coronavirus disease 2019 (COVID-19) patients post discharge (re-detectable positive, RP) remained elusive.
Summary Background It has been reported that several cases recovered from COVID-19 tested positive for SARS-CoV-2 after discharge (re-detectable positive, RP), however the clinical characteristics, significance and potential cause of RP patients remained elusive. Methods A total 262 were discharged January 23 to February 25, 2020, enrolled analysis their parameters. The non-RP (NRP) grouped according disease severity during hospitalization period. characterization at re-admission hospital...
Abstract Background A new type of novel coronavirus infection (COVID-19) occurred in Wuhan, Hubei Province. Previous investigations reported patients Wuhan city often progressed into severe or critical and had a high mortality rate.The clinical characteristics affected outside the epicenter province are less well understood. Methods All confirmed COVID-19 case treated Third People’s Hospital Shenzhen,from January 11, 2020 to February 6, 2020, were included this study. We analyzed...
With the current coronavirus disease (COVID-19) pandemic and high endemic levels of chronic hepatitis B virus (HBV) infection worldwide, it is urgent to investigate liver function changes COVID-19 patients with HBV infection, how severe acute respiratory syndrome 2 (SARS-CoV-2) in turn affects course infection.We undertook a retrospective study based on 347 (21 vs. 326 without infection). propensity score matching (PSM) method, we yielded 20 51 matched for group non-HBV group,...
Severe coronavirus disease 2019 (COVID-19) is often indicated by lymphopenia and increased myelopoiesis; however, the underlying mechanism still unclear, especially alteration of hematopoiesis. It important to explore what extent how hematopoietic stem cells contribute impairment peripheral lymphoid myeloid compartments in COVID-19 patients. In this study, we used single-cell RNA sequencing assess bone marrow mononuclear from patients with blood as control. The results showed that these were...
The continuous evolution of SARS-CoV-2 variants constitutes a significant impediment to the public health. World Health Organization (WHO) has designated variant JN.1, which evolved from its progenitor BA.2.86, as Variant Interest (VOI) in light enhanced immune evasion and transmissibility. proliferating dissemination JN.1 globally accentuates competitive superiority potential instigate fresh surges infection, notably among cohorts previously infected by antecedent variants. Notably,...
To evaluate the capacity of Versant HCV genotype assay (LiPA) 2.0 to identify hepatitis C virus (HCV) genotypes, 110 serum samples were collected from chronic patients. Three methods compared: core sequence analysis, NS5B analysis and INNO-LiPA assay. The result showed that 102 (92.7%) amplified in either or both regions, which 97 region 62 region. Correlation amplification rates subgenomic regions associated with viral loads. Basic local alignment search tool (BLAST) phylogenetic classified...
533 Background: To develop and validate a predictive model to identify hepatocellular carcinoma (HCC) patients likely benefit from combined treatment of transarterial chemoembolization (TACE), molecular targeted therapies (MTTs), immune checkpoint inhibitors (ICIs). Methods: Data 500 with unresectable HCC treated TACE, MTTs, ICIs (2019-2023) were analyzed. Patients divided into training set (241 Nanfang Hospital) validation (259 various hospitals). Key prognostic variables identified using...
Liver fibrosis is a common response to chronic liver injury due multiple etiologies and plays crucial in the progression of disease cirrhosis, hepatocellular carcinoma, other liver-related clinical outcomes. Currently, available treatments block are designed eliminate underlying causes disease. The lack truly effective drugs regress or reverse major unmet need. In this context, article briefly describes pathological process hepatic focuses on reviewing progress studies mechanism-based...
Hepatocellular carcinoma (HCC) is a common malignancy with poor prognosis and high mortality. To identify key genes associated HCC the underlying mechanisms, we performed weighted correlation network analysis (WGCNA) of potential HCC. We identified 17 closely related to by yellow module combined PPI analysis. Verification role these revealed that SPC25 knockdown results in significant decrease proliferation metastasis cells increased protein levels components p53 pathway vitro. In summary,...
Computed tomography (CT) is widely used to evaluate the severity of COVID-19 infection and track disease progression. We described changes in chest CT enable better understanding progression during hospitalization.Consecutively hospitalized patients admitted from January 11, 2020 February 16, followed until March 26, at Third People's Hospital Shenzhen, China were included. Semi- quantitative analysis was assess shape, distribution, range lung lesions. For each image, lungs divided into six...
The standard treatment for patients with chronic hepatitis C (CHC), pegylated interferon-α (PEG-IFN) plus ribavirin (RBV) does not provide a sustained virological response (SVR) in all patients. Genetic variations at the interleukin 28B (IL-28B) locus are important predicting outcome following therapy CHC patients.We investigated role of IL28B (rs8099917) to PEG-IFN-α/RBV and evaluated its association risk null (NVR) relapse (REL) different viral genotypes. We found that overall...
This study aimed to investigate pulmonary function and radiological outcomes in a group of coronavirus disease 2019 (COVID-19) survivors.One hundred seventy-two COVID-19 survivors follow-up clinic referral hospital underwent high-resolution computed tomography (CT) the thorax at 3 months after discharge.The median duration from discharge test (interquartile range) was 90 (88-95) days. Abnormal found 11 (6.40%) patients, abnormal small airway (FEF25-75%) 12 (6.98%). Six (3.49%) patients had...
Currently, hepatitis C antiviral therapy is entering a new era with the use of direct-acting (DAA) agents. However, precise immunological influences DAA in patients chronic (CHC) are insufficiently understood. This study aimed to investigate effects on frequency myeloid-derived suppressor cells (MDSCs), T lymphocytes, and natural killer (NK) CHC. Thirty-two treatment-naive CHC were treated therapy, immune was analyzed by flow cytometry at various time points during after therapy. Sixteen...
The direct-acting antiviral agents (DAAs) have drastically improved the prognosis of hepatitis C virus (HCV) patients. However, resistance-associated variants (RAVs) to DAAs may hamper treatment. There was a lack data on prevalence pre-exist RAVs in Chinese HCV-infected We performed nested PCR assays 74 HCV genotype 1b-infected patients amplify viral regions NS3, NS5A, and NS5B investigate treatment-naive genotype1b-infected China. mutations A156S, T54S, D168Y NS3/4A region were found 18.33%...
The serine-threonine protein phosphatase 2A (PP2A) is a heterotrimeric enzyme complex that plays vital role in regulating male reproductive activities. However, as an essential member of the PP2A family, physiological functions regulatory subunit B55α ( PPP2R2A ) testis remain inconclusive. Hu sheep are noted for their precocity and fertility, ideal models study physiology. Here, we analyzed expression patterns tract at different developmental stages further investigated its testosterone...