A5100409070- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis B Virus Studies
- Renal Transplantation Outcomes and Treatments
- Pancreatic and Hepatic Oncology Research
- Transplantation: Methods and Outcomes
- Influenza Virus Research Studies
- Cerebrovascular and Carotid Artery Diseases
- Hepatitis C virus research
- Organ Donation and Transplantation
- COVID-19 Clinical Research Studies
- Inflammatory Biomarkers in Disease Prognosis
- Intracranial Aneurysms: Treatment and Complications
- Pancreatic function and diabetes
- SARS-CoV-2 and COVID-19 Research
- Cancer Immunotherapy and Biomarkers
- Autophagy in Disease and Therapy
- Respiratory viral infections research
- Spine and Intervertebral Disc Pathology
- Medical Imaging and Analysis
- Cancer Genomics and Diagnostics
- Immune Response and Inflammation
- Radiomics and Machine Learning in Medical Imaging
Wenzhou Medical University
2023-2025
Wenzhou Central Hospital
2017-2025
Zhejiang University
2014-2024
First Affiliated Hospital Zhejiang University
2012-2024
Southern University of Science and Technology
2020-2024
Soochow University
2022-2024
Second Affiliated Hospital of Soochow University
2022-2024
Harbin Medical University
2020-2024
Third Affiliated Hospital of Harbin Medical University
2020-2024
Sanya Central Hospital
2023
Recent data on the coronavirus disease 2019 (COVID-19) outbreak caused by severe acute respiratory syndrome 2 (SARS-CoV-2) has begun to shine light impact of liver. But no studies date have systematically described liver test abnormalities in patients with COVID-19. We evaluated clinical characteristics COVID-19 abnormal results.Clinical records and laboratory results were obtained from 417 laboratory-confirmed who admitted only referral hospital Shenzhen, China January 11 February 21, 2020...
Tislelizumab (anti-programmed cell death protein 1 antibody) showed preliminary antitumor activity and tolerability in patients with advanced solid tumors, including hepatocellular carcinoma (HCC). This study aimed to assess the efficacy safety of tislelizumab previously treated HCC.The multiregional phase 2 RATIONALE-208 examined single-agent (200 mg intravenously every 3 weeks) HCC Child-Pugh A, Barcelona Clinic Liver Cancer stage B or C, who had received one more prior lines systemic...
Clinical and laboratory data available on patients with Ebola virus disease (EVD) remain extremely limited. We summarized the clinical characteristics of EVD analyzed factors related to their death.Patients admitted for care at Freetown China-Sierra Leone Friendship Hospital during 1 October-14 November 2014 were enrolled in this study. The these retrospectively analyzed.Sixty-one confirmed have EVD; 28 them (45.9%) male 33 (54.1%) female. Their median age was years (range, 1.17-67 years)....
Abstract Introduction Postoperative delirium is a common clinical manifestation in geriatric patients, resulting prolonged hospitalization and increased economic burden, addition to higher morbidity mortality rates. Therefore, identifying non‐obvious risk factors that contribute the development of postoperative patients crucial. Methods From J anuary 2011 une 2013, 200 over 65 years age scheduled for orthopedic surgery were randomly selected statistically analyzed with respect effects...
There is a lack of useful biomarkers for predicting the efficacy anti–programmed death-1 (PD-1) therapy advanced gastric and colorectal cancer. To address this issue, in study we investigated correlation between inflammatory marker expression survival patients with Data 111 cancer treated anti–PD-1 regimens were retrospectively analyzed. Neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte (MLR), platelet-to-lymphocyte (PLR), clinical characteristics each patient selected as main...
Summary The anti‐multiple myeloma (MM) efficacy of bortezomib has led to the development other proteasome inhibitors (PI), including CEP‐18770 which shown anti‐MM effects in preclinical studies. However, orally (PO) or intravenously (IV) administered multiple MM models and combination with conventional therapies not been evaluated. Herein, we show that combined melphalan induces synergistic inhibition cell viability vitro . In xenograft models, addition IV completely prevented growth both...
Background De novo malignancies occur after liver transplantation because of immunosuppression and improved long-term survival. But the spectrums associated risk factors remain unclear. Aims To describe overall pattern de cancers in transplant recipients. Methods Data from Scientific Registry Transplant Recipients October 1987 to December 2009 were analyzed. The spectrum cancer was analyzed logistic-regression used identify predictors do malignancies. Results Among 89,036 recipients, 6,834...
Recent studies have indicated that a number of long noncoding RNAs (lncRNAs) are dysregulated in hepatocellular carcinoma, while their aberrant expressions associated with tumorigenesis and poor prognosis. To identify hepatitis B virus (HBV)‐related lncRNAs, we used RNA deep sequencing to quantify the abundances lncRNAs HepG2 cells HBV transgenic HepG2‐4D14 cells. Here, demonstrate lnc‐HUR1 is significantly upregulated We found HBV‐encoded x protein can enhance transcription lnc‐HUR1....
ABSTRACT Hepatitis B virus (HBV)-encoded X protein (HBx) plays a critical role in HBV-related hepatocarcinoma development. In this study, we demonstrate that HBx is specifically modified by NEDD8. We found E3 ligase HDM2 promotes NEDDylation of to enhance stability preventing its ubiquitination-mediated degradation. Consistently, analysis 160 hepatocellular carcinoma patient specimens indicated the amount correlates with level. identified K91 and K95 as key sites observed...
Background The use of the immunosuppressive drug tacrolimus (TAC) is related to new onset diabetes after transplantation. Herein, we examined effect intraperitoneal administered TAC on intestinal glucose absorption in mice. Methods Animals received low, medium, or high dose (0.5, 1, 5 mg/kg/d, respectively), 0.9% saline solution (control) for 14 days. Oral tolerance test (OGTT), insulin concentration test, and serum measurements was performed days exposure. Plasma assessed electrogenic were...
The insatiable demand for lithium in portable energy storage necessitates a sustainable and low-carbon approach to its recovery. Conventional hydrometallurgical pyrometallurgical methods heavily involve hazardous chemicals significant CO 2 emissions. Herein, by integrating electrode oxidation with electrolyte oxidation, we establish photovoltaic-driven “dual-oxidation” seawater electrolyzer system footprint high A 98.96% leaching rate 99.60% product purity was demonstrated recovery from...
Background Salvage liver transplantation (SLT) has been reported as being feasible for patients who develop recurrent hepatocellular carcinoma (HCC) after primary resection, but this finding remains controversial. We retrospectively studied the clinical characteristics of SLT recipients and conducted a comparison between (PLT) recipients. Methodology Principal Findings A retrospective study examined data from China Liver Transplant Registry (CLTR) 6,975 transplants performed January 1999 to...
The aim of the present study was to investigate survival and prognostic factors patients who were with advanced esophageal squamous cell carcinoma (ESCC) developed an fistula. data from 221 ESCC fistula January 2008 December 2017 at Harbin Medical University Cancer Hospital retrospectively analyzed. Hazard ratios (HRs) 95% confidence intervals (CIs) estimated by Cox proportional hazard models. median time after a diagnosis calculated using Kaplan-Meier method. We found that pathogens...
The present study aimed to explore the effect of Saikosaponin D (SSD) and its underlying mechanism on apoptosis autophagy in human breast cancer MDA‑MB‑231 cells. MTT assay, flow cytometry, western blotting confocal fluorescence microscopy detection were employed. SSD, a kind triterpenoid saponins extracted from Radix bupleuri, has been demonstrated have effects anti‑inflammatory, antioxidative anticancer can regulate autophagy. revealed that SSD induced through activation p38...
Background: Homer scaffold protein 1 (homer1) may harbor neuroprotective effects against acute brain injury. This study aimed to investigate the prognostic role of serum homer1 in human aneurysmal subarachnoid hemorrhage (aSAH). Methods: A total 209 patients with aSAH and 100 controls were encompassed this prospective cohort study. Serum levels quantified at admission all patients, on post-aSAH days 1, 3, 5, 7, 10, 14 83 recruitments controls. The modified Fisher scale (mFisher) World...
We characterize $\tau$-tilting modules as $1$-tilting over quotient algebras satisfying a tensor-vanishing condition, and ${\rm Tor}^1$-vanishing condition. use delooping levels to study \emph{Self-orthogonal Conjecture}: any self-orthogonal module is $1$-tilting. confirm the conjecture when endomorphism algebra of has finite global level.
e16201 Background: Systemic and locoregional combination therapy has demonstrated promising outcomes for unresectable hepatocellular carcinoma (uHCC). The purpose of this study was to evaluate the efficacy safety Tislelizumab Lenvatinib in with hepatic artery infusion chemotherapy (HAIC) plus transarterial chemoembolization (TACE) initial uHCC high tumor burden. Methods: From January 2023 December 2024, 20 patients who received FOLFOX-HAIC/TACE combined (200mg, q3w) (8/12mg, qd) were...