A5100364833- HIV/AIDS drug development and treatment
- Tuberculosis Research and Epidemiology
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV Research and Treatment
- Antifungal resistance and susceptibility
- SARS-CoV-2 and COVID-19 Research
- HIV/AIDS Research and Interventions
- COVID-19 Clinical Research Studies
- HIV-related health complications and treatments
- Viral Infections and Vectors
- Synthesis and Biological Evaluation
- Infectious Diseases and Tuberculosis
- SARS-CoV-2 detection and testing
- Mycobacterium research and diagnosis
- Hair Growth and Disorders
- Enterobacteriaceae and Cronobacter Research
- Pneumonia and Respiratory Infections
- Genetic Associations and Epidemiology
- Long-Term Effects of COVID-19
- Mycotoxins in Agriculture and Food
- Family Caregiving in Mental Illness
- Bone health and osteoporosis research
- Helicobacter pylori-related gastroenterology studies
- Therapeutic Uses of Natural Elements
- Viral gastroenteritis research and epidemiology
Fudan University
2024-2025
People's Liberation Army 411 Hospital
2025
Peking Union Medical College Hospital
2023-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2025
The First Affiliated Hospital, Sun Yat-sen University
2025
Sun Yat-sen University
2025
Perinatal HIV Research Unit
2022-2023
Dongguan People’s Hospital
2019-2023
CanSino (China)
2023
Army Medical University
2021-2023
Clinical and laboratory data available on patients with Ebola virus disease (EVD) remain extremely limited. We summarized the clinical characteristics of EVD analyzed factors related to their death.Patients admitted for care at Freetown China-Sierra Leone Friendship Hospital during 1 October-14 November 2014 were enrolled in this study. The these retrospectively analyzed.Sixty-one confirmed have EVD; 28 them (45.9%) male 33 (54.1%) female. Their median age was years (range, 1.17-67 years)....
Background The global impact of SARS-CoV-2 and its associated coronavirus disease (COVID-19) has necessitated urgent characterization prognostic biomarkers. This study aimed to delineate the epidemiological clinical predictors mortality among hospitalized COVID-19 patients. Methods A retrospective cohort was conducted on 123 patients with laboratory-confirmed admitted Huoshenshan Hospital (Wuhan, China) from 1 February 2020 30 April 2020. Kaplan–Meier curve multivariate Cox regression were...
The COVID-19 pandemic has spread worldwide, and rapid detection of the SARS-CoV-2 virus is crucial for infection surveillance epidemic control. This study developed a centrifugal microfluidics-based multiplex reverse transcription recombinase polymerase amplification (RT-RPA) assay endpoint fluorescence E, N, ORF1ab genes SARS-CoV-2. microscope slide-shaped microfluidic chip could simultaneously accomplish three target one reference human gene (i.e., ACTB) RT-RPA reactions in 30 min,...
Magnesium is a vital mineral that plays crucial role in various physiological processes, and its imbalance has been associated with many chronic aging-related diseases. Traditional assessment methods are insufficient, the Depletion Score (MDS) proposed as significant indicator. Klotho, transmembrane protein, involved aging regulation oxidative stress modulation. Despite shared relevance of MDS Klotho to aging, their relationship remains unclear. This study aims investigate between levels...
Background: Metagenomic next-generation sequencing (mNGS) has emerged as a revolutionary tool for infectious disease diagnostics. The necessity of mNGS in real-world clinical practice common Lower Respiratory Tract Infections (LRTI) needs further evaluation. Methods: A total 184 bronchoalveolar lavage fluid (BALF) samples and 322 sputa associated with LRTI were fully examined. detection performance was compared between standard microbiology culture, using Sanger the reference method....
Abstract Background: Dual regimen dolutegravir (DTG) plus lamivudine (3TC) has demonstrated non-inferior efficacy compared to DTG-based three-drug regimens (3DRs), yet directly comparative data regarding the and safety of DTG + 3TC bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) for therapy-naïve people with human immunodeficiency virus (HIV)-1 (PWH) are still limited. We aimed assess antiviral potency profiles vs. B/F/TAF based on antiretroviral therapy (ART)-naïve PWH in China....
Background The management of latent tuberculosis infection (LTBI) is a key action for the realization “End (TB) Strategy” worldwide, and it important to identify priority populations. In this prospective cohort study, we evaluated prevalence LTBI incidence active TB among close contacts explored suitable control strategy in schools. Methods We designed with 2 years follow-up, recruiting freshman/sophomore patients’ from three administrative districts Shanghai. These were chosen based on...
Background Blepharophimosis-ptosis-epicanthus inversus syndrome (BPES) is a rare autosomal dominant condition characterized by typical eyelid malformations that include blepharophimosis, ptosis, epicanthus inversus, and telecanthus. Methods We retrospectively reviewed 125 consecutive BPES patients who underwent staged surgical intervention from July 2003 to December 2011. All initial medial lateral canthoplasties, followed blephroptosis correction 6 12 months afterward. The parameters were...
Abstract Background Tuberculosis (TB) is one of the top 10 causes death in world. Since Directly Observed Therapy (DOT) as a core strategy for global TB control are not applicable to all types patients, and self-management patients (SMTP) patient-centered supervision type supplement DOT can improve case management. However, factors related SMTP complex need more study. This study aimed at identifying determinants examining direct/indirect effects these determinants. Methods The purposive...
Tuberculosis remains a major threat to global public health. Regarding its control, directly observed therapy is not suitable as strategy for all tuberculosis patients. Self-management may be an important patient-centered case management supplement therapy. However, there currently no well-established instrument measuring the self-management of This study aimed develop and validate scale patients.We developed initial based on health promotion indicators framework by our research group. After...
Limited real-world data on dolutegravir (DTG) plus lamivudine (3TC) for HIV-1-infected individuals have been reported. This study aimed to evaluated the efficacy and safety of DTG + 3TC in ART-naïve adults China. prospective observational cohort enrolled receiving ART initiation with (D3 group) or tenofovir efavirenz (TDF EFV, TLE subgroups low viral load (LVL, ≤500,000 copies/mL) high (HVL, >500,000 according baseline HIV-1 RNA. Efficacy were assessed by proportion virologic suppression,...
An approach toward novel neutralizing IgY polyclonal antibodies (N-IgY-pAb) against SARS-CoV-2 S-ECD was developed.The N-IgY-pAb and its intranasal spray response the wild type ("'WH-Human 1") virus, variants of Delta or Omicron were up to 98%. Unique virus peptides binding screened by a proteome microarray.Seventeen mutation-free with Z-score > 3.0 identified as potent targets from total 966 peptides. The new findings show that one is in RBM domain (461LKPFERDISTEIYQA475 ), two are NTD...
Fungal pathogens are a major threat to public health, as they becoming increasingly common and resistant treatment, with only four classes of antifungal medicines currently available few candidates in the clinical development pipeline. Most fungal lack rapid sensitive diagnostic techniques, those that exist not widely or affordable. In this study, we introduce novel automated susceptibility testing system, Droplet 48, which detects fluorescence microdilution wells real time fits growth...
Exploration of plasma proteins associated with osteoporosis can offer insights into its pathological development, identify novel biomarkers for screening high-risk populations, and facilitate the discovery effective therapeutic targets.