A5100380016- Pregnancy-related medical research
- Acupuncture Treatment Research Studies
- Healthcare and Venom Research
- Traditional Chinese Medicine Studies
- Dialysis and Renal Disease Management
- Acute Kidney Injury Research
- Muscle and Compartmental Disorders
- Clinical practice guidelines implementation
- Meta-analysis and systematic reviews
- Liver Disease Diagnosis and Treatment
- Cancer Treatment and Pharmacology
- Complementary and Alternative Medicine Studies
- Advanced Breast Cancer Therapies
- Atmospheric chemistry and aerosols
- Urinary Bladder and Prostate Research
- Gastrointestinal disorders and treatments
- Toxin Mechanisms and Immunotoxins
- Reproductive Biology and Fertility
- Immune Cell Function and Interaction
- Neuropeptides and Animal Physiology
- Neurological Disorders and Treatments
- Pneumonia and Respiratory Infections
- Obstructive Sleep Apnea Research
- Traditional Chinese Medicine Analysis
- Air Quality and Health Impacts
Foshan Hospital of TCM
2024-2025
Beijing Children’s Hospital
2015-2025
Capital Medical University
2009-2025
Shanghai East Hospital
2011-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2010-2025
Shanghai Ninth People's Hospital
2017-2025
Shanghai Jiao Tong University
2017-2025
Peking Union Medical College Hospital
2017-2025
Zhongshan Hospital
2025
Fudan University
2025
In this paper, a nanosized porous metal–organic framework, Fe-MIL-88NH2, was facilely prepared with uniform octahedral shape by the addition of acetic acid, and for first time demonstrated to possess intrinsic peroxidase-like activity. Kinetic analysis electron spin resonance measurements indicated that catalytic behavior consistent typical Michaelis–Menten kinetics follows ping-pong mechanism. As novel peroxidase mimic material, Fe-MIL-88NH2 shows advantages high efficiency, ultrahigh...
Can dydrogesterone (DYG) be used as an alternative progestin in a progesterone primed ovarian stimulation (PPOS) protocol? DYG can appropriate PPOS protocol. is new regimen based on freeze-all strategy that uses to GnRH analog for suppressing premature LH surge during the follicular phase. Medroxyprogesterone acetate (MPA) has been successfully adjuvant gonadotrophin However, use of MPA may lead stronger pituitary suppression and thus require higher dosage hMG longer duration than...
Acupuncture is widely used worldwide, and systematic reviews on acupuncture are increasingly being published. Although share several essential elements with other reviews, some information for the application of not covered by Preferred Reporting Items Systematic Meta-Analyses (PRISMA) statement. Considering this, we aimed to develop an extension PRISMA statement reviews.We as a starting point, conducted this study referring development strategy recommended EQUATOR network. The initial items...
<h3>Importance</h3> Multiple immunostimulatory agonist antibodies have been clinically tested in solid tumors to evaluate the role of targeting glucocorticoid-induced tumor necrosis factor (TNF) receptor–related protein anticancer treatments. <h3>Objective</h3> To safety and activity fully human TNF IgG1 monoclonal antibody BMS-986156 with or without nivolumab patients advanced tumors. <h3>Design, Setting, Participants</h3> This global, open-label, phase 1/2a study enrolled 292 18 years...
Abstract Background Trastuzumab deruxtecan (T-DXd, DS-8201) is an antibody-drug conjugate with a HER2 antibody, tetrapeptide-based cleavable linker, and novel topoisomerase I inhibitor payload. DESTINY-Breast01 (NCT03248492) open-label, international, multicenter, phase 2 study of T-DXd in patients positive metastatic breast cancer (MBC) supported regulatory approval the US Japan. Updated longer-term safety efficacy results are presented here. Methods All were required to have MBC that...
Abstract Background: T-DXd is a HER2-targeting antibody-drug conjugate approved for the treatment of pts with advanced HER2+ mBC based on DESTINY-Breast01 study (NCT03248492). DESTINY-Breast03 (NCT03529110) isa randomized, multicenter, open-label, phase 3 assessing efficacy and safety vs. T-DM1 in previously treated trastuzumab taxane. In primary analysis, demonstrated clinically meaningful statistically significant improvement PFS (Corteset al, ESMO 2021). this exploratory we provide...
Structural information of grassland changes on the Tibetan Plateau is essential for understanding alterations in critical ecosystem functioning and their underlying drivers that may reflect environmental changes. However, such at regional scale still lacking due to methodological limitations. Beyond remote sensing indicators only recognizing vegetation productivity, we utilized multivariate data fusion deep learning characterize formation-based plant community structure alpine grasslands...
Squalene epoxidase (SQLE) promotes metabolic dysfunction-associated steatohepatitis-associated hepatocellular carcinoma (MASH-HCC), but its role in modulating the tumour immune microenvironment MASH-HCC remains unclear.
Urelumab, a fully human, non-ligand binding, CD137 agonist IgG4 monoclonal antibody, enhances T-cell and natural killer-cell antitumor activity in preclinical models, may enhance cytotoxic of rituximab. Here we report results patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL), follicular (FL), other lymphomas, phase 1 studies evaluating urelumab alone (NCT01471210) combined rituximab (NCT01775631). Sixty received (0.3 mg/kg IV Q3W, 8 mg Q6W); 46 (0.1 mg/kg, 0.3 Q3W)...
526 Background: Patients (pts) with HER2+ metastatic breast cancer (mBC) are at high risk of developing brain metastases (BMs), and treatment options limited once BMs occur. T-DXd is an antibody-drug conjugate composed anti-HER2 antibody, a cleavable tetrapeptide-based linker, topoisomerase I inhibitor payload. On the basis findings phase 2 DESTINY-Breast01 trial (NCT03248492), was approved for adult pts unresectable or mBC who have received ≥2 prior anti-HER2–based regimens (US Europe) had...
Resources can affect plant productivity and biodiversity simultaneously thus are key drivers of their relationships in addition to plant-plant interactions. However, most previous studies only focused on a single resource while neglecting the nature multidimensionality. Here we integrated four essential resources for growth into metric diversity (RD) investigate its effects productivity-biodiversity relationship (PBR) across Chinese grasslands. Results showed that habitats differing RD have...
Aims: The mechanisms coordinating maturation with an environment-driven metabolic shift, a critical step in determining the developmental potential of human vitro (IVM) oocytes, remain to be elucidated. Here we explored key genes regulating oocyte using single-cell RNA sequencing and illuminated compensatory mechanism from perspective by analyzing gene expression. Results: Three that encode CoA-related enzymes were screened data. Two them, ACAT1 HADHA, closely related regulation substrate...
Background The gut microbiota plays a pivotal role in the development of diabetes and kidney disease. However, it is not clear how intestinal microecological imbalance involved context diabetic disease (DKD), leading cause renal failure. Objectives To elucidate microbial signatures associated with DKD progression towards end-stage (ESRD) explore whether they could reflect dysfunction psychological distress. Methods A cross-sectional study was conducted to 29 non-ESRD patients 19 ESRD...
The “lipotoxicity” hypothesis holds that fat-induced hepatic insulin resistance (FIHIR) may play a major role in the pathogenesis of type 2 diabetes. Berberine has been reported to have antidiabetic properties. However, molecular mechanisms for this action are not fully clarified. Therefore, we will investigate gene expression alterations involved therapeutic effect berberine on FIHIR diabetic hamsters and possible mechanisms. In study, were induced by high-fat diet with streptozotocin...