A5101730780- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Amoebic Infections and Treatments
- Hepatitis C virus research
- Drug-Induced Hepatotoxicity and Protection
- Hepatitis B Virus Studies
- Liver Diseases and Immunity
- Long-Term Effects of COVID-19
- Antibiotic Resistance in Bacteria
- Advanced MRI Techniques and Applications
- Urinary Tract Infections Management
- Trace Elements in Health
- Lung Cancer Treatments and Mutations
- Neuroendocrine Tumor Research Advances
- Pancreatitis Pathology and Treatment
- Lung Cancer Research Studies
- Lung Cancer Diagnosis and Treatment
- Neurological disorders and treatments
- Pharmacological Effects of Natural Compounds
- Viral Infections and Outbreaks Research
- Clostridium difficile and Clostridium perfringens research
- Extracellular vesicles in disease
- Neurological diseases and metabolism
Beijing Tian Tan Hospital
2023-2025
Chinese PLA General Hospital
2019-2024
National Clinical Research Center for Digestive Diseases
2023
Peking University
2021-2023
Peking University Cancer Hospital
2021-2023
New York University
2023
Capital Medical University
2023
Chinese People's Liberation Army
2020
302 Military Hospital of China
2013-2020
Abstract Background We aimed to clarify high-risk factors for coronavirus disease 2019 (COVID-19) with multivariate analysis and establish a predictive model of progression help clinicians better choose therapeutic strategy. Methods All consecutive patients COVID-19 admitted Fuyang Second People’s Hospital or the Fifth Medical Center Chinese PLA General between 20 January 22 February 2020 were enrolled their clinical data retrospectively collected. Multivariate Cox regression was used...
Clinical and laboratory data on patients with coronavirus disease 2019 (COVID-19) in Beijing, China, remain extremely limited. In this study, we summarized the clinical characteristics of COVID-19 from a designated hospital Beijing. total, 55 laboratory-confirmed SARS-CoV-2 infection Beijing 302 Hospital were enrolled study. Demographic data, symptoms, comorbidities, values, treatments, outcomes all collected retrospectively analyzed. A total 15 (27.3%) had severe mean age was 44.0 years...
Chronic hepatitis B (CHB) and liver fibrosis are associated with a high risk of hepatocellular carcinoma (HCC) development. We assessed whether entecavir (ETV) plus Biejia-Ruangan compound (BRC), an anti-fibrotic traditional Chinese medicine, can further reduce the HCC in treatment-naïve patients CHB Ishak score ≥3 points derived from our parent double-blind randomized placebo-controlled trial.After 72-week comparison between ETV+BRC ETV+placebo treatment, participants were eligible to enter...
Clinical and laboratory data available on patients with Ebola virus disease (EVD) remain extremely limited. We summarized the clinical characteristics of EVD analyzed factors related to their death.Patients admitted for care at Freetown China-Sierra Leone Friendship Hospital during 1 October-14 November 2014 were enrolled in this study. The these retrospectively analyzed.Sixty-one confirmed have EVD; 28 them (45.9%) male 33 (54.1%) female. Their median age was years (range, 1.17-67 years)....
Summary Background Treatment of chronic drug‐induced liver injury (DILI) or herb‐induced injury(HILI) is an important and unresolved challenge. There no consensus regarding the indications for corticosteroids DILI/HILI. Aims To investigate efficacy safety corticosteroid plus glycyrrhizin patients with Methods This was a randomised open‐label trial. Eligible causality assessment using updated RUCAM were randomly assigned (1:1) either to steroid treatment group (48‐week stepwise dose reduction...
Long-term nucleos(t)ide analogue (NA) treatment can reverse liver fibrosis in chronic hepatitis B (CHB), but its effect on regression remains limited. Biejia-Ruangan (BR) has been approved China as an antifibrotic traditional Chinese medicine drug patients with diseases. A multicenter randomized controlled trial aims to evaluate the of BR CHB treated NAs.CHB histologically confirmed advanced or cirrhosis were randomly assigned receive entecavir (ETV) (0.5 mg per day) plus (2 g 3 times a...
To clarify high-risk factors and develop a nomogram model to predict biochemical resolution or nonresolution (BNR) in patients with chronic DILI.
Bloodstream infections (BSIs) are a frequently observed complication in liver cirrhosis patients. This study aimed to investigate the microbiological characteristics and outcomes of BSIs patients with cirrhosis. We retrospectively studied 852 who developed BSI. Patient outcome was evaluated using 30-day mortality assessed multivariate stepwise logistic regression analysis. Antibiotic sensitivity pathogens tested. Gram-negative bacteria were responsible for 59.6% BSIs, Gram-positive caused...
<title>Abstract</title> Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease affecting both upper and lower motor neurons, with median survival of 3–5 years [1]. The key challenge in diagnosis lies the early detection neuron (UMN) impairment, which mainly depends on clinical examination but can be obscured by severe (LMN) impairment [2]. Consequently, searching for alternative UMN markers has become critical focus ALS research. Recent magnetic resonance imaging (MRI)...
Abstract Background and Aims The use of corticosteroids in chronic drug‐induced liver injury (DILI) is an important issue. Our previous randomized controlled trial showed that patients with DILI benefited from a 48‐week steroid stepwise reduction (SSR) regimen. However, it remains unclear whether shorter course therapy can achieve similar efficacy. In this study, we aimed to assess 36‐week SSR efficacy SSR. Methods A open‐label was performed. Eligible were randomly assigned the 36‐ or (1:1)...
// Yangxin Xie 1, 2, * , Bo Tu Xin Zhang 2 Jingfeng Bi 3 Lei Shi Peng Zhao Weiwei Chen Suxia Liu 4 Dongping Xu and Enqiang Qin 1 Treatment Research Center for Infectious Diseases, Beijing 302 Hospital, Beijing, China Chinese PLA General Medical School, Clinical Translational Medicine, Liver Failure, These authors have contributed equally to this work Correspondence to: Xu, email: xudongping302@sina.com Qin, qeq2004@sina.com Keywords: liver cirrhosis; gram-negative bacterial bloodstream...
The novel coronavirus disease 2019 (COVID-19) epidemic is the severe global pandemic with large numbers of infected cases and deaths in recent decades. previous studies were all about influence albumin (ALB) for severity mortality in-patients COVID-19. But few exist factors to achieve viral negative conversion. Therefore, this study conducted an exploratory investigate effect on conversion rate.Among 190 hospitalized patients moderate COVID-19 who had a course longer than 30 days, 102...
Background Spontaneous bacterial peritonitis (SBP) is a detrimental infection of the ascitic fluid in liver cirrhosis patients, with high mortality and morbidity. Early diagnosis timely antibiotic administration have successfully decreased rate to 20%-25%. However, many patients cannot be diagnosed early stages due absence classical SBP symptoms. asymptomatic remains great challenge clinic. Aim To establish multivariate predictive model for using positive microbial cultures from ascites....
// Bo Tu 1, * , Jingfeng Bi 2, Dan Wu Peng Zhao 1 Lei Shi Yangxin Xie Xin Zhang Zhe Xu Suxia Liu 3 Xinhua Wang 4 Xiaoxi Li 5 Fusheng and Enqiang Qin Center for Infectious Disease, Beijing 302 Hospital, 100039, China 2 Clinical Research Management, Liver Failure, Obstetrics Gynecology, Laboratory, These authors contributed equally to this work Correspondence to: Wang, email: o034nmfd@yeah.net Qin, qeq2004@sina.com Keywords: liver cirrhosis; bloodstream infection; MELD; hospital-acquired BSI;...
There were significant differences in response and pharmacokinetic characteristics to the peginterferon α2a treatment among Chronic Hepatitis B (CHB) patients. The aim of this study is identify factors which could significantly impact CHB 208 blood samples collected from 178 patients who considered as had been treated with followed by concentration measurement other laboratory tests. covariates such demographic clinical retrieved medical records. Nonlinear mixed-effects modeling method was...
Objectives Magnetic susceptibility changes in brain MRI of Wilson’s disease (WD) patients have been described subcortical nuclei especially the basal ganglia. The objectives this study were to investigate its relationship with other microstructural and functional alterations diagnostic utility these MRI-related metrics. Methods A total 22 WD 20 healthy controls (HCs) underwent 3.0T multimodal scanning. Susceptibility, volume, diffusion indices whole-brain connectivity putamen (PU), globus...
Background Trans‐stenotic pressure gradient (TPG) measurement is essential for idiopathic intracranial hypertension (IIH) patients with transverse sinus (TS) stenosis. Four‐D flow MRI may provide a noninvasive imaging method differentiation of IIH different TPG. Purpose To investigate the associations between 4D parameters and TPG, to evaluate diagnostic performance in differentiating high TPG (Group HP ) from low LP ). Study type Prospective. Population 31 TS stenosis (age, 38 ± 12 years;...
Since severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread from the early epicenter, Wuhan, to rest of China, virulence SARS-CoV-2 might have evolved at different phases pandemic. We therefore compared unique features among 62 disease 2019 (COVID-19) inpatients who contracted in Wuhan (15 cases), exposed patients (26 or acquired without exposure (21 cases). Median incubation periods are 4.5 days (3–5) for patients, 8 (3–11) those infected by and 12 (7–13) aforementioned...
Esophagogastric varices (EGV) are common complications of primary biliary cholangitis (PBC). We examined the risk factors for variceal bleeding-related liver transplantation (LT) or death. This prospective observational cohort study involved PBC in our hospital from 1 January 2005 to 2020. The clinical endpoints were LT and Survival analysis was performed using Kaplan–Meier estimate, cox regression investigate factors. with EGV had significantly shorter survival than those without (p =...