A5100451092- Liver Disease Diagnosis and Treatment
- Drug-Induced Hepatotoxicity and Protection
- Liver Disease and Transplantation
- Gastric Cancer Management and Outcomes
- Liver Diseases and Immunity
- Inflammatory Biomarkers in Disease Prognosis
- Cancer Immunotherapy and Biomarkers
- Drug Transport and Resistance Mechanisms
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Essential Oils and Antimicrobial Activity
- Hepatitis B Virus Studies
- Pancreatic and Hepatic Oncology Research
- Diet, Metabolism, and Disease
- Plant-based Medicinal Research
- Advancements in Transdermal Drug Delivery
- Hepatocellular Carcinoma Treatment and Prognosis
- Lung Cancer Research Studies
- Lung Cancer Treatments and Mutations
- Cervical Cancer and HPV Research
- Alcohol Consumption and Health Effects
- Ovarian cancer diagnosis and treatment
- Pharmacological Effects of Natural Compounds
- Cardiac Arrest and Resuscitation
- Organ Transplantation Techniques and Outcomes
- Traumatic Brain Injury Research
Dongshin University
2025
Liaoning Cancer Hospital & Institute
2020-2024
China Medical University
2020-2024
Second Military Medical University
2022-2024
Sichuan University
2012-2024
Chinese PLA General Hospital
2021-2024
Shanghai University of Finance and Economics
2024
Shanghai University of Traditional Chinese Medicine
2024
China Astronaut Research and Training Center
2024
Shanghai Tenth People's Hospital
2022-2024
Abstract Background and Aims About 20% of patients receiving nucleos(t)ide analogues treatment experienced low‐level viraemia (LLV), which is associated with progression liver fibrosis high risk hepatocellular carcinoma. We aimed to evaluate the effectiveness safety switching from entecavir (ETV) tenofovir alafenamide fumarate (TAF) in ETV‐treated LLV. Methods In this prospective study, LLV, presented our hospital December 2018 October 2019, were enrolled. Switching TAF or continuing ETV was...
Families and clinicians have limited validated tools available to assist in estimating long-term outcomes early after pediatric cardiac arrest. Blood-based brain-specific biomarkers may be helpful aid outcome assessment. To analyze the association of blood-based brain injury biomarker concentrations with 1 year The Personalizing Outcomes After Child Cardiac Arrest multicenter prospective cohort study was conducted intensive care units at 14 academic referral centers US between May 16, 2017,...
Abstract A randomized, active‐controlled clinical trial was conducted to examine the effect of pulsed electromagnetic fields (PEMFs) on women with postmenopausal osteoporosis (PMO) in southwest China. Forty‐four participants were randomly assigned receive alendronate or one course PEMFs treatment. The primary endpoint mean percentage change bone mineral density lumbar spine (BMDL), and secondary endpoints changes left proximal femur (BMDF), serum 25OH vitamin D3 (25(OH)D) concentrations,...
Diabetes induces impairment in cognitive function. There is substantial evidence that hippocampal endoplasmic reticulum (ER) stress involved diabetic impairment. Hydrogen sulfide (H2S) attenuates the learning and memory decline experimental Alzheimer's disease inhibits ER homocysteine-exposed rats. Therefore, this aim of present work was to investigate whether H2S ameliorates dysfunction involving inhibition stress. In work, we found stretozotocin (STZ, 40 mg/kg)-induced rats exhibited...
Cervical cancer is the most common gynecological malignancy and screening for risk factors with early detection has been shown to reduce mortality. In this study, we aimed analyze characteristics of human papillomavirus (HPV) infection precancerous lesions in women provide clinical evidence developing strategies prevent cervical women. Furthermore, evaluated influencing high-risk HPV infection. From April 2018 December 2021, 10,628 were recruited at Liaoning Cancer Hospital, Shenyang...
Purpose Suicide is a global concern, especially among young people. prediction models have the potential to make it easier identify patients who are at high risk of suicide, but they very little predictive power when there positive value for suicide mortality. Therefore, aim study uncover factors associated with by self-poisoning and further provide trustworthy nomogram predict poisoned patients. Methods This prospectively enrolled 237 were treated poisoning Fifth Medical Center PLA General...
The objective of this study was to investigate the impact surgical margin and hepatic resection on prognosis compare their importance in patients with hepatocellular carcinoma (HCC).The clinical data 906 HCC who underwent our hospital from January 2013 2015 were collected retrospectively. All divided into anatomical (AR) (n = 234) nonanatomical (NAR) group 672) according type resection. effects AR NAR wide narrow margins overall survival (OS) time recurrence (TTR) analyzed.In all patients,...
Abstract Introduction Increasing evidence shows the close association between prognostic nutritional index (PNI) and overall survival (OS) of solid cancers including lung cancer. However, role PNI in non‐small cell cancer patients (NSCLC) with bone metastasis remains unclear. Objective To explore NSCLC metastasis. Methods A retrospective analysis 259 initially diagnosed was conducted. Univariate multivariate were used to assess potential roles parameters. Results The most common symptoms...
<h3>Objective</h3> There is an unmet need to improve clinical outcomes for patients with recurrent/metastatic cervical cancer. Checkpoint inhibitors represent a promising treatment strategy. We evaluated the safety and anti-tumor activity of zimberelimab, anti-programmed cell death protein-1 antibody, in previously treated, recurrent, metastatic <h3>Methods</h3> This phase II, single-arm, open-label study used Simon two-stage minimax design. Eligible were women aged 18–75 years programmed...
Numbers of prognostic factors small cell lung cancer (SCLC) have been demonstrated in previous studies. However, the identification biomarkers with easy access, convenience, and low consumption is great value clinics.In order to find such a biomarker, single institution study 1156 SCLC patients was retrospectively conducted assess nutritional index (PNI) on treated platinum-based chemotherapy.The optimal cut-off values were determined by receiver operating characteristic (ROC) curve...
To clarify high-risk factors and develop a nomogram model to predict biochemical resolution or nonresolution (BNR) in patients with chronic DILI.
The Symptom Checklist (SCL) developed by the Health Behaviour in School‑aged Children (HBSC) study is widely used to capture psychosomatic complaints (PSC) of non-clinical children and adolescents. Although its psychometric properties have been well established internationally, performance Mandarin Chinese version remains unclear. This evaluates HBSC-SCL's properties, develops norm, creates corresponding scoring algorithm. Data were collected from a two-wave cross-sectional survey conducted...
In familial hypercholesterolemia (FH), high-density lipoprotein (HDL) often becomes dysfunctional and enriched with lipid peroxidation products, potentially contributing to increased thrombotic risk. However, its specific effects on platelet function thrombosis remain unclear. Whether targeting HDL oxidation can restore protective role has yet be determined. Platelet in healthy FH subjects was assessed via flow cytometry, TEM, western blotting, transcriptome analysis. The of from...
Serum biochemical liver tests (LTs) (alanine aminotransferase, aspartate and gamma glutamyltransferase) platelet counts are often used to screen for chronic disease. We determined the prevalence etiologies of abnormal LTs in an adult population Jilin, China.A total 3791 individuals between ages 18 79 years were interviewed then underwent ultrasonography blood tests.The was 14.77% (560 out subjects). The risk factors non-alcoholic fatty disease (NAFLD) alone, which accounted 11.61%, metabolic...
Hydrogen sulfide (H2 S) plays antidepressant-like roles in diabetic rats. However, the underlying mechanisms remain unclear. Brain-derived neurotropic factor (BDNF), a neurotrophic factor, important regulatory depression by its high-affinity tropomysin-related kinase B (TrkB) receptor. Autophagy also is implicated modulation of depression. Previous work confirmed modulatory H2 S BDNF protein expression and autophagy. Thus, this study, we explored whether BDNF-TrkB pathway mediates effects...
Objective We report the efficacy and safety of serplulimab, a novel humanized anti–programmed death-1 antibody, plus nanoparticle albumin-bound (nab)-paclitaxel in previously treated patients with programmed death ligand-1 (PD-L1)–positive advanced cervical cancer. Methods Patients diagnosed PD-L1–positive (combined positive score ≥1) cancer were enrolled this single-arm, open-label, phase II study. They given serplulimab 4.5 mg/kg for up to 2 years (35 dosing cycles) nab-paclitaxel 260 mg/m...
Currently, research on biopsy-proven acute drug-induced liver injury (DILI) remains limited. This study aimed to identify clinical characteristics and risk factors for significant hepatic inflammation in patients with DILI. An ambispective cohort was conducted DILI admitted our hospital from 2012 2018. Using the Scheuer scoring system, were categorized into G0-2 or G3-4 groups followed up 12 months after first admission. Clinical outcomes retrieved medical records. The median age of 157...