A5035613025- Bone and Joint Diseases
- Mesenchymal stem cell research
- High-pressure geophysics and materials
- Bone Metabolism and Diseases
- Hip disorders and treatments
- Cancer Cells and Metastasis
- Nerve injury and regeneration
- Bone health and osteoporosis research
- Dental Research and COVID-19
- MicroRNA in disease regulation
- Virtual Reality Applications and Impacts
- Tryptophan and brain disorders
- Neurogenesis and neuroplasticity mechanisms
- Peroxisome Proliferator-Activated Receptors
- Dental Radiography and Imaging
- Quantum, superfluid, helium dynamics
- Extracellular vesicles in disease
- Fusion materials and technologies
- Ubiquitin and proteasome pathways
- Cancer, Hypoxia, and Metabolism
- Body Composition Measurement Techniques
- Bone and Dental Protein Studies
- Diagnosis and Treatment of Venous Diseases
- Cancer-related Molecular Pathways
- Neonatal Respiratory Health Research
Peking University
2015-2025
China Three Gorges University
2025
National Clinical Research Center for Digestive Diseases
2020-2025
Peking University People's Hospital
2025
Chengdu Medical College
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2024
First Affiliated Hospital of Jiangxi Medical College
2024
Credo Reference (United States)
2024
Ningbo University
2024
National Health and Family Planning Commission
2024
The dysfunction of bone marrow stromal cells (BMSCs) may be a core factor in Type 2 diabetes mellitus (T2DM) associated osteoporosis.However, the underlying mechanism is not well understood.Here, we delineated critical role insulin impeding osteogenesis BMSCs T2DM.Compared with from healthy people (H-BMSCs), T2DM patient (DM-BMSCs) showed decreased osteogenic differentiation and autophagy level, increased senescent phenotype.H-BMSCs incubated hyperglycemic hyperinsulinemic conditions...
Depression is an inflammatory-related condition, with the progression in neuronal damage resulting major depression disorder. Ginsenoside-Rg1, a sterol extract from herb Panax ginseng , has been shown to exert neuroprotective effects upon neurodegeneration disorders. However, whether ginsenoside-Rg1 confers antidepressant-like on neuroinflammation as associated depression, well possible mechanism involved these effects, currently unclear. In present report, we show that treatment (40 mg/kg,...
Abstract Activating autologous stem cells after the implantation of biomaterials is an important process to initiate bone regeneration. Although several studies have demonstrated mechanism biomaterial‐mediated regeneration, a comprehensive single‐cell level transcriptomic map revealing influence on regulating temporal and spatial expression patterns mesenchymal (MSCs) still lacking. Herein, osteoimmune microenvironment depicted around classical collagen/nanohydroxyapatite‐based repair...
Background Endothelial cells ( EC s) form blood vessels through angiogenesis that is regulated by coordination of vascular endothelial growth factor VEGF ), Notch, transforming β, and other signals, but the detailed molecular mechanisms remain unclear. Methods Results Small RNA sequencing initially identified miR‐342‐5p as a novel downstream molecule Notch signaling in s. Reporter assay, quantitative reverse transcription polymerase chain reaction Western blot analysis indicated targeted...
Hydrogen sulfide (H2S) is a crucial signaling molecule with wide range of physiological functions. Previously, we confirmed that stress-induced depression accompanied disturbance H2S generation in hippocampus. The present work attempted to investigate the inhibitory effect on chronic unpredictable mild depressive-like behaviors and underlying mechanism. We established rat model stress simulate depression. Open field test, forced swim tail suspension test were used assess behaviors....
Artesunate, a derivative of artemisinin isolated from Artemisia annua L., has been traditionally used to treat malaria, and artesunate demonstrated cytotoxic effects against variety cancer cells. However, there is little available information about the antitumor on human gastric In present study, we investigated effect cells whether its associated with reduction in COX-2 expression. The growth apoptosis were by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, flow...
Autophagy serves as a stress response and may contribute to the pathogenesis of avascular necrosis femoral head induced by steroids. Statins promote angiogenesis ameliorate endothelial functions through apoptosis inhibition progenitor cells, however process used statins modulate autophagy in remains unclear. This manuscript determines whether pravastatin protects against dexamethasone-induced activating cell autophagy. Pravastatin was observed enhance activity specifically upregulating...
Tissue inflammation is an important problem in the field of human adipose-derived stem cell (ASC)-based therapeutic bone regeneration. Many studies indicate that inflammatory cytokines are disadvantageous for osteogenic differentiation and formation. Therefore, overcoming would be greatly beneficial promoting ASC-mediated The present study aims to investigate potential anti-inflammatory role Prostaglandin G/H synthase 1 (PTGS1) during ASCs. We performed TNFα treatment response PTGS1...
Virtual reality (VR) dental simulators are currently used in preclinical skills training. However, with the development of extended technologies, use mixed (MR) has shown significant advantages over VR.This study aimed to describe research and a newly developed MR haptic-based simulator for tooth preparation conduct preliminary evaluation its face validity.A prototype was by integrating head-mounted display (HMD), special force feedback handles, foot pedal, computer hardware, software...
Background Melanosomes are specialized membrane-surrounded organelles, which involved in the synthesis, storage and transport of melanin. Glycoprotein (transmembrane) non-metastatic melanoma protein b (GPNMB), a melanosome-specific structural protein, shares significant amino acid sequence homology with Pmel-17. Proteomic analysis demonstrated that GPNMB is present all stages (I-IV) melanosomes. However, little known about role Methodology/Principal Findings Using real-time quantitative PCR,...
Prevascularization strategies have become a hot spot in tissue engineering. As one of the potential candidates for seed cells, skin precursor-derived Schwann cells (SKP-SCs) were endowed with new role to more efficiently construct prevascularized tissue-engineered peripheral nerves. The silk fibroin scaffolds seeded SKP-SCs through subcutaneously implantation, which was further assembled SKP-SC-containing chitosan conduit. expressed pro-angiogenic factors vitro and vivo. significantly...
Periodontal diseases are prevalent among middle-aged and elderly individuals. There's still no satisfactory solution for tooth loss caused by periodontal diseases. Human ligament stem cells (hPDLSCs) is a distinctive subgroup of mesenchymal cells, which play crucial role in supportive tissues, but their application value hasn't been fully explored yet. As regulatory subunit PI3K, PIK3R3's cell regulation remains poorly comprehended. This study aims to explore the effect PIK3R3 on...
Purpose This paper investigates the language attitudes of ethnic minority junior secondary school students in a complex ecology Urumqi, People’s Republic China. It focuses on these towards Uyghur, Mandarin Chinese and English. Design/methodology/approach Methods comprise questionnaire survey interviews. The 294 three schools catering for asked about their languages. Using Likert scale open-ended questions, it covers social affective aspects. Semi-structured group interviews individual...
Mesenchymal stem cells (MSCs) are a reliable resource for bone regeneration and tissue engineering, but the molecular mechanisms of differentiation remain unclear. The tumor antigen 15-leucine-rich repeat containing membrane protein (LRRC15) is transmembrane demonstrated to play important roles in cancer. However, little known about its role osteogenesis. This study was evaluate functions LRRC15 osteogenic MSCs. Osteogenic-induction treatment ovariectomized (OVX) model were performed...
Abstract Osteonecrosis of the femoral head (ONFH) primarily results from ischemia/hypoxia to head, and one cellular manifestations is endoplasmic reticulum (ER) stress. To understand possible linkage ischemic osteonecrosis ER stress, a surgery-induced animal model was employed salubrinal administered evaluate role Salubrinal synthetic chemical that inhibits de-phosphorylation eIF2α, it can suppress cell death stress at proper dose. The indicated associated with ONFH significantly improved...
Hydrogen sulfide (H2 S) plays antidepressant-like roles in diabetic rats. However, the underlying mechanisms remain unclear. Brain-derived neurotropic factor (BDNF), a neurotrophic factor, important regulatory depression by its high-affinity tropomysin-related kinase B (TrkB) receptor. Autophagy also is implicated modulation of depression. Previous work confirmed modulatory H2 S BDNF protein expression and autophagy. Thus, this study, we explored whether BDNF-TrkB pathway mediates effects...
Abstract Schwann cells experience de-differentiation, proliferation, migration, re-differentiation and myelination, participate in the repair regeneration of injured peripheral nerves. Our previous sequencing analysis suggested that gene expression level matrix metalloproteinase 7 (MMP7), a cell-secreted proteolytic enzyme, was robustly elevated rat sciatic nerve segments after injury. However, biological roles MMP7 are poorly understood. Here, we exposed primary cultured with recombinant...
The E3 ubiquitin ligase complex CDC20-activated anaphase-promoting complex/Cyclosome (APC/CCDC20 ) plays a critical role in governing mitotic progression by targeting key cell cycle regulators for degradation. Cell division protein 20 homolog (CDC20), the co-activator of APC/C, is required full activity. In addition to its well-known cycle-related functions, we demonstrate that CDC20 an essential osteogenic commitment bone marrow mesenchymal stromal/stem cells (BMSCs). Cdc20 conditional...
The origin of life and native tissue development are dependent on the heterogeneity pluripotent stem cells. Bone marrow mesenchymal cells (BMMSCs) located in a complicated niche with variable matrix stiffnesses, resulting divergent cell fates. However, how stiffness drives fate remains unknown. For this study, we performed whole-gene transcriptomics precise untargeted metabolomics sequencing to elucidate complex interaction network transcriptional metabolic signals extracellular matrices...