A5101815170- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Neuroscience of respiration and sleep
- Neurogenesis and neuroplasticity mechanisms
- Ovarian function and disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- RNA Research and Splicing
- Neuroendocrine regulation and behavior
- Cerebrospinal fluid and hydrocephalus
- Ginseng Biological Effects and Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA Interference and Gene Delivery
- Photoreceptor and optogenetics research
- RNA modifications and cancer
- Nerve injury and regeneration
- Reproductive Biology and Fertility
- Ultrasound and Hyperthermia Applications
- NF-κB Signaling Pathways
- Birth, Development, and Health
- Immune Response and Inflammation
- Ion Channels and Receptors
- MicroRNA in disease regulation
- Regulation of Appetite and Obesity
- Cancer-related molecular mechanisms research
- Luminescence and Fluorescent Materials
Hebei University of Chinese Medicine
2024-2025
First Affiliated Hospital of Anhui Medical University
2024-2025
Anhui Medical University
2024-2025
Shandong Provincial Hospital
2009-2023
Shandong First Medical University
2023
West Virginia University
2021-2023
Beijing Chao-Yang Hospital
2022-2023
Capital Medical University
2022-2023
University of Cincinnati Medical Center
2020-2023
Sabin Vaccine Institute
2023
Ligation of TLR4 with LPS in macrophages leads to the production proinflammatory cytokines, which are central eliminate viral and bacterial infection. However, uncontrolled activation may contribute pathogenesis inflammatory diseases such as septic shock. In this study, we found microRNA‐210 was induced murine by LPS. Transfection miR‐210 mimics significantly inhibited LPS‐induced cytokines. contrast, transfection anti‐miR‐210 inhibitors increased expression Furthermore, demonstrated that...
Protein ubiquitination plays an essential role in the regulation of retinoic acid-inducible gene I (RIG-I) activation and antiviral immune response. However, function opposite process deubiquitination RIG-I remains elusive. In this study, we have identified deubiquitinating enzyme ubiquitin-specific protease 4 (USP4) as a new regulator for through stabilization RIG-I. USP4 expression was attenuated after virus-induced activation. Overexpression significantly enhanced protein RIG-I-triggered...
Depression is considered a neuropsychiatric disease associated with various neuronal changes within specific brain regions. We previously reported that ginsenoside-Rg1, potential neuroprotective agent extracted from ginseng, significantly alleviated depressive-like disorders induced by chronic stress in rats. However, the mechanisms which ginsenoside-Rg1 exerts its effects depression remain largely uncharacterized. In present study we confirm prevented antidepressant-like rat model of...
Are telomere length and telomerase activity associated with biochemical primary ovarian insufficiency (POI)?Shortened diminished were POI.POI is a result of pathological reproductive aging encompasses occult, overt stages. Studies have indicated as biomarker for biological aging.A total 120 patients POI 279 control women recruited by the Center Reproductive Medicine Shandong University.Telomere in peripheral blood leukocytes (LTL) granulosa cells (GTL) was measured using modified...
Background Opening of the blood-brain barrier (BBB) induced with MRI-guided focused ultrasound has been shown in experimental animal models to reduce amyloid-β plaque burden, improve memory performance, and facilitate delivery therapeutic agents brain. However, physiologic effects this procedure humans Alzheimer disease (AD) require further investigation. Purpose To assess imaging ultrasound–induced BBB opening hippocampus human participants early AD evaluate fluid flow patterns after by...
Depression is suggested to be a neuropsychiatric disease resulting from neuroinflammation within specific brain regions. Curcumin, potential neuroprotective agent extracted curcuma loga, exerts antidepressant-like effects in various animal models of depression. However, the underlying mechanisms, particular whether curcumin may exert neuroprotection through suppression inflammatory pathway activity depression remains largely unknown. In present study, we examined molecular events as related...
Autism spectrum disorder (ASD) is a group of extensive neurodevelopmental disorders for which few efficacious drugs are available. Sodium selenite (Se), the most common inorganic form selenium given to humans and animals, has antioxidant, anti-inflammatory, neuroprotective effects in several psychiatric neurological disorders. However, effect Se on ASD unclear.Using BTBR T + tf/J (BTBR) mouse model ASD, we investigated therapeutic underlying mechanism action ASD. mice were randomly divided...
Abstract Background Focused ultrasound (FUS)-mediated blood–brain barrier (BBB) opening is under investigation as a therapeutic modality for neurodegeneration, yet its effects in humans are incompletely understood. Here, we assessed physiologic responses to FUS administered multifocal brain sites of persons with Alzheimer’s disease (AD). Methods At tertiary neuroscience institute, eight participants AD (mean age 65, 38% F) enrolled phase 2 clinical trial underwent three successive targeted...
Ginsenoside Rg1 has been demonstrated to exhibit neuroprotective effects in various studies. This study aimed investigate the neuronal mechanisms underlying and antidepressant-like of ginsenoside a rat model depression.Chronic unpredictable mild stress was used induce depression-like behaviors rats. Transmission electron microscopy observe synapses within basolateral amygdala (BLA). The expression microRNA (miR)-134 BLA verified by real-time quantitative PCR. Finally, synaptic...
Depression is an inflammatory-related condition, with the progression in neuronal damage resulting major depression disorder. Ginsenoside-Rg1, a sterol extract from herb Panax ginseng , has been shown to exert neuroprotective effects upon neurodegeneration disorders. However, whether ginsenoside-Rg1 confers antidepressant-like on neuroinflammation as associated depression, well possible mechanism involved these effects, currently unclear. In present report, we show that treatment (40 mg/kg,...
Macrophages are critical for regulation of inflammatory response during endotoxemia and septic shock. However, the mediators underlying their regulatory function remain obscure. Growth differentiation factor 3 (GDF3), a member transforming growth beta (TGF-β) superfamily, has been implicated in response. Nonetheless, role GDF3 macrophage-regulated endotoxemia/sepsis is unknown. Here, we show that serum levels patients elevated strongly correlate with severity sepsis 28-day mortality....
Background Dexmedetomidine has repeatedly shown to improve anxiety, but the precise neural mechanisms underlying this effect remain incompletely understood. This study aims explore role of corticotropin-releasing hormone–producing hypothalamic paraventricular nucleus (CRH PVN ) neurons in mediating anxiolytic effects dexmedetomidine. Methods A social defeat stress mouse model was used evaluate induced by dexmedetomidine through elevated plus maze, open-field test, and measurement serum...
Our previous genome-wide association study identified LH/choriogonadotropin receptor (LHCGR) as a susceptibility gene for polycystic ovary syndrome (PCOS). The objective of this was to determine whether the genetic or epigenetic components associated with LHCGR participate in pathogenesis PCOS. exons and flanking regions were sequenced from 192 women PCOS, no novel somatic mutations identified. In addition, methylation statuses 6 cytosine-phosphate-guanine (CpG) sites promoter region...
Abstract Osteopontin (OPN) is expressed by various immune cells and modulates both innate adaptive responses. However, the molecular mechanisms that control opn gene expression, especially at chromatin level, remain largely unknown. We have previously demonstrated many specific cis- trans-regulatory elements determine extent of endotoxin (LPS)-mediated induction OPN synthesis in murine macrophages. In present study, we confirm NF-κB also plays an important role setting LPS-stimulated...
Background Fat mass and obesity-associated gene (FTO) has been associated with obesity, especially the common variant rs9939609. Polycystic ovary syndrome (PCOS) is a complex endocrine-metabolic disorder over 50% of patients are overweight/obese. Thus FTO potential candidate for PCOS but their relationship confusing remains to be clarified in different population large sample size. Method This study was performed adopting two-stage design by genotyping SNP The first set comprise 741 704...
It has been reported that aquaporin-4 (AQP4) deficiency impairs transportation between the cerebrospinal fluid and interstitial (ISF) as well clearance of solutes in superficial brain. However, effect AQP4 on ISF flow deep brain remains unclear. This study compared caudate nucleus thalamus normal rats (NO) knockout (KO) using tracer-based magnetic resonance imaging. The rate slowed to different degrees two regions KO rats' brains. Compared with NO rats, half-life was significantly prolonged,...
Leptin, an anorexigenic hormone in the hypothalamus, suppresses food intake and increases energy expenditure. Failure to respond leptin will lead obesity. Here, we discovered that nuclear receptor Nur77 expression is lower hypothalamus of obese mice compared with normal mice. Injection results significant reduction body weight wild-type but not knockout (KO) littermates or specific knockdown hypothalamus. Hypothalamic only participates central control also expands leptin's reach liver...