A5083446090- Genomics and Phylogenetic Studies
- Cancer-related molecular mechanisms research
- Leptospirosis research and findings
- Genetic diversity and population structure
- Marine and coastal plant biology
- T-cell and Retrovirus Studies
- Hedgehog Signaling Pathway Studies
- MicroRNA in disease regulation
- Immune Response and Inflammation
- Mycobacterium research and diagnosis
- interferon and immune responses
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Chromosomal and Genetic Variations
- Identification and Quantification in Food
- Microbial Community Ecology and Physiology
- Aquaculture disease management and microbiota
- Genetic and phenotypic traits in livestock
- Soil Carbon and Nitrogen Dynamics
- RNA modifications and cancer
- Plant Pathogens and Fungal Diseases
- Marine Biology and Ecology Research
- Plant Diversity and Evolution
- Climate change impacts on agriculture
- Circular RNAs in diseases
- Aquaculture Nutrition and Growth
Northeast Forestry University
2021-2025
Zhengzhou University
2025
Jining University
2022-2025
Qufu Normal University
2009-2025
Zhengzhou Children's Hospital
2025
Lanzhou University
2025
Tianjin University of Traditional Chinese Medicine
2021-2025
North Minzu University
2021-2025
State Ethnic Affairs Commission
2021-2025
Beijing Forestry University
2025
NLRP3 inflammasome plays a critical role in the activation of caspase‐1 and maturation IL‐1β. However, specific cis ‐ trans ‐regulatory elements that determine extent expression are not well defined. In this study, we found was induced by TLR agonists murine macrophages NF‐κB dependent manner. Furthermore, corresponding binding sites (nt −1303 to −1292 −1238 −1228) were identified promoter. Finally, EMSA ChIP assays demonstrated LPS‐induced Therefore, out results delineated molecular...
Abstract Early weaning usually causes intestinal disorders, enteritis, and diarrhea in young animals human infants. Astragalus polysaccharides (APS) possesses anti‐inflammatory activity. To study the mechanisms of APS its potential effects on health, we performed an RNA sequencing (RNA‐seq) lipopolysaccharide (LPS)‐stimulated porcine epithelial cells (IPEC‐J2) vitro. In addition, LPS‐stimulated BALB/c mice were used to inflammation vivo. The results from RNA‐seq analysis show that there 107,...
Salmonella typhimurium (S.T) is a common cause of acute, self-limiting food-borne diarrhea with severe intestinal inflammation and barrier damage. Oleanolic acid (OA), isolated from almost 2000 plant species, has been shown to have anti-inflammatory roles. The purpose this study was investigate the potential protective effects OA on S.T-induced enteritis elucidate its mechanisms. A total eighty BALB/c mice (4-week-old) were randomly divided into control group (no S.T, no OA), S.T (S.T only),...
Circular RNAs (circRNAs) are a class of widespread and diverse covalently closed circular endogenous that exert crucial functions in regulating gene expression mammals. However, the function regulation mechanism circRNAs lower vertebrates still unknown. Here, we discovered novel circRNA derived from PIKfyve, named circPIKfyve, is related to antiviral responses teleost fish. The results showed circPIKfyve plays essential roles host immunity inhibition SCRV replication. Moreover, also found...
Abstract Osteopontin (OPN) is expressed by various immune cells and modulates both innate adaptive responses. However, the molecular mechanisms that control opn gene expression, especially at chromatin level, remain largely unknown. We have previously demonstrated many specific cis- trans-regulatory elements determine extent of endotoxin (LPS)-mediated induction OPN synthesis in murine macrophages. In present study, we confirm NF-κB also plays an important role setting LPS-stimulated...
A series of ferrocene-appended half-sandwiched iridium(III) phenylpyridine complexes have been designed and synthesized. These show better anticancer activity than cisplatin widely used in clinic under the same conditions. Meanwhile, could effectively inhibit cell migration colony formation. Complexes interact with protein transport through serum protein, catalyzing oxidation nicotinamide-adenine dinucleotid inducing accumulation reactive oxygen species (ROS, 1O2), which confirmed mechanism...
Upon recognition of bacterial or viral components by pattern receptors, cells could be activated to produce inflammatory cytokines, type I IFN, and IFN-stimulated genes. These antibacterial antiviral immunities are tightly regulated the host prevent inappropriate immune responses. MicroRNAs (miRNAs) have emerged as an essential regulatory network with profound effects on mammalian inflammation responses, but networks miRNA-mediated response in lower vertebrates remain largely unknown. In...
The gut microbiota is a complex and essential system organ that plays an integrative role in balancing key vital functions the host. Knowledge of impact altitude on European mouflon (Ovis orientalis musimon) blue sheep (Pseudois nayaur) currently limited. In this study, we compared characteristics 5 at low (K group), 4 high (L (M (N group). V3-V4 region 16S rRNA gene was analyzed using high-throughput sequencing. Analyses based operational taxonomic units showed significant changes microbial...
The Hedgehog (Hh) family of secreted proteins is essential for development in both vertebrates and invertebrates. As one main morphogens during metazoan development, the graded Hh signal transduced across plasma membrane by Smoothened (Smo) through differential phosphorylation its cytoplasmic tail, leading to pathway activation expression target genes. However, how Smo transduces via Costal2 (Cos2)/Fused (Fu) complex remains poorly understood. Here we present a model cell response gradient...
Fluorescent iridium(<sc>iii</sc>) coumarin-salicylaldehyde Schiff base antitumor compounds change the ROS and Δ<italic>Ψ</italic><sub>m</sub>, induce lysosomal damage, lead to apoptosis.
Abstract Although sex determination and differentiation are key developmental processes in animals, the involvement of non-coding RNA regulation this process is still not clarified. The tiger pufferfish ( Takifugu rubripes ) one most economically important marine cultured species Asia, but analyses miRNA long (lncRNA) at early stages have been conducted yet. In our study, high-throughput sequencing technology was used to sequence transcriptome libraries from undifferentiated gonads T. ....
Intestinal coccidiosis is a common parasitic disease in livestock, caused by the infection of Eimeria and Cystoisospora parasites, which results great economic losses to animal husbandry. Triazine compounds, such as toltrazuril diclazuril, are widely used treatment chemoprophylaxis coccidiosis. Unfortunately, widespread drug resistance has compromised their effectiveness. Most studies have focused on prophylaxis therapeutics with flocks, while comprehensive understanding how alters...
Abstract In growing children, growth plate cartilage has limited self-repair ability upon fracture injury always leading to limb arrest. Interestingly, one type of injuries within the achieve amazing self-healing, however, mechanism is unclear. Using this mouse model, we discovered activation Hedgehog (Hh) signaling in injured plate, which could activate chondrocytes and promote repair. Primary cilia are central transduction mediator Hh signaling. Notably, ciliary Hh-Smo-Gli pathways were...
Salvia miltiorrhiza, a traditional Chinese herbal medicine, is used to treat various inflammatory diseases. In the present study, antiinflammatory effects of S. miltiorrhiza lipid-soluble extracts (SMLE) were demonstrated in vitro and vivo, along with its underlying mechanism action. SMLE significantly inhibited production NO, TNF-α, IL-1β IL-6 lipopolysaccharides (LPS)-stimulated RAW 264.7 cells. also LPS-induced degradation IκB-α cytoplasm translocation p65 nucleus addition, intracellular...
Inflammatory bowel diseases (IBDs), including ulcerative colitis (UC) and Crohn's disease (CD), are chronic inflammatory disorders caused by genetic influences, the immune system environmental factors. However, underlying pathogenesis of IBDs pivotal molecular interactions remain to be fully elucidated. The aim present study was identify signatures in patients with elucidate potential mechanisms IBD subtypes. gene expression profiles GSE75214 datasets were obtained from Gene Expression...