A5076211418- MicroRNA in disease regulation
- Pharmacological Effects of Natural Compounds
- Traditional Chinese Medicine Analysis
- Orbital Angular Momentum in Optics
- Metabolomics and Mass Spectrometry Studies
- Metamaterials and Metasurfaces Applications
- Flavonoids in Medical Research
- Gut microbiota and health
- Cancer-related molecular mechanisms research
- interferon and immune responses
- Aquaculture disease management and microbiota
- Tryptophan and brain disorders
- Advanced Antenna and Metasurface Technologies
- Photonic Crystals and Applications
- Medicinal Plants and Bioactive Compounds
- Ginseng Biological Effects and Applications
- Circular RNAs in diseases
- Natural product bioactivities and synthesis
- Chromatography in Natural Products
- Soil Moisture and Remote Sensing
- Alzheimer's disease research and treatments
- Phytochemistry and Biological Activities
- Peroxisome Proliferator-Activated Receptors
- Computational Drug Discovery Methods
- Plasmonic and Surface Plasmon Research
Qinghai University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2025
Harbin Institute of Technology
2023-2025
Chinese Academy of Sciences
2019-2025
Institute of Genetics and Developmental Biology
2025
Qingdao University of Science and Technology
2024
Harbin Engineering University
2023
Beijing University of Technology
2023
China Academy of Chinese Medical Sciences
2022-2023
Shanghai Ocean University
2021-2022
Neuroinflammation is often characterized by an overactive microglial response. Curcumin, known for its anti-inflammatory and antioxidant properties, can mitigate hyperactivity following epileptic seizures. The study delves into the molecular mechanisms underlying curcumin's modulation of RNA post-transcriptional N (6)-methyladenosine (m6A) modification. It found that curcumin interacts with Z1-type protein tyrosine phosphatase receptor (PTPRZ1), maintaining enzymatic activity thus regulating...
Abstract Background In recent years, excellent results have suggested an association between the “brain-gut” axis and Alzheimer’s disease (AD) progression, yet role of in AD pathogenesis still remains obscure. Herein, we provided a potential link central peripheral neuroinflammatory disorders progression. Methods The Morris water maze (MWM) test, immunohistochemistry, ELISA, ProcartaPlex Multiplex immunoassay, multiple LC-MS/MS methods, V3-V4 regions 16S rRNA genes were applied to explore...
Circular RNAs (circRNAs) are a class of widespread and diverse covalently closed circular endogenous that exert crucial functions in regulating gene expression mammals. However, the function regulation mechanism circRNAs lower vertebrates still unknown. Here, we discovered novel circRNA derived from PIKfyve, named circPIKfyve, is related to antiviral responses teleost fish. The results showed circPIKfyve plays essential roles host immunity inhibition SCRV replication. Moreover, also found...
Arenobufagin (ArBu) is a natural anticancer drug with good anti-tumor effects, but its clinical applications and development potential are limited due to toxicity. The purpose of this study reduce the toxic side effects ArBu improve efficacy tumor treatment by incorporating it into poly(ethylene glycol)-b-poly (lactide) co-polymer (PEG-PLA). ArBu@PEG-PLA micelles were prepared thin film hydration method. optimized characterized size, stability, loading, encapsulation rate, release....
Siniperca chuatsi rhabdovirus (SCRV) is a typical fish RNA rhabdovirus, which one of the most significant viral pathogens in teleost and can cause severe hemorrhagic septicemia freshwater marine fishes. Here, we discovered highly conserved circRNA called circRasGEF1B, acts as key regulator for innate antiviral responses upon SCRV infection. circRasGEF1B an endogenous sponge miR-21-3p that downregulates expression levels. able to bind directly regulates MITA expression.
Bound states in the continuum (BICs) have been widely observed many symmetric geometries optical system during last decade. Here, we consider a scenario which structure is designed asymmetrically with anisotropic birefringent material embedded one-dimensional photonic crystals. This kind of new shape opens possibility obtaining symmetry-protected BICs (SP-BICs) and Friedrich–Wintgen (FW-BICs) form tunable anisotropy axis tilt. Interestingly, these can be as high-Q resonances by variation...
Abstract Background Jianwei Xiaoshi oral liquid (JWXS), a classical traditional prescription comprising various edible medicinal plants, has demonstrated significant efficacy in treating paediatric indigestion. It originates from Jianpi Pill, which is developed the Ming Dynasty and nourishes spleen regulates gastrointestinal function. However, specific molecular mechanisms involved remain unclear. Methods To elucidate material base of JWXS its underlying mechanism dyspepsia, UHPLC–Q–Orbitrap...
Abstract Hybrid‐order Poincaré beams (HyOPBs) with complex transverse polarization states hold significant potential in optical communication and quantum information. Fully characterizing the parameters of HyOPBs is a key task to accelerate applications. Conventional methods typically require mapping multiple reconstructing point by point, creating fundamental bottleneck for fast measurement real‐time monitoring parameters. In this work, single‐shot characterization scheme demonstrated...
Psoriasis brings economic and mental burdens to patients, the exact etiology pathogenesis of psoriasis are still unclear. Compounds herbal medicine have potential for treatment. This study aims explore characteristic genes psoriasis, which compounds may target. Four differential gene expression datasets, with 181 healthy skin lesion samples, were used analysis. employed random forest, neural network, support vector machine algorithms identify associated psoriasis. The identified validated...
We report herein an environmentally friendly and pyrolysis-free synthesis strategy to prepare efficient supported catalyst with Pt single-atom modified sub-nanometric Ru clusters for all-pH HER.
Emerging evidence suggested the association between gut dysbiosis and Alzheimer's disease (AD) progression. However, it remained unclear how microbiome neuroinflammation in brain mutually interact or these interactions affect functioning cognition. Here we hypothesized that "gut-brain" axis mediated by microbial derived metabolites was expected to novel breakthroughs fields of AD research development. Multiple technologies, such as immunofluorescence, 16s rDNA sequencing, mass...