A5002860009- ECG Monitoring and Analysis
- Metabolomics and Mass Spectrometry Studies
- Traditional Chinese Medicine Analysis
- Machine Learning in Healthcare
- Antimicrobial Peptides and Activities
- Parkinson's Disease Mechanisms and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Non-Invasive Vital Sign Monitoring
- Infection Control and Ventilation
- Building Energy and Comfort Optimization
- Liver Disease Diagnosis and Treatment
- Ginseng Biological Effects and Applications
- Biomedical Text Mining and Ontologies
- Gut microbiota and health
- Phytochemistry and Biological Activities
- Chemical Synthesis and Analysis
- Flavonoids in Medical Research
- Artificial Intelligence in Healthcare
- Neurobiology and Insect Physiology Research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Plant-based Medicinal Research
- Inflammasome and immune disorders
- Immune Response and Inflammation
- Cardiac electrophysiology and arrhythmias
- Chronic Myeloid Leukemia Treatments
Shanghai Jiao Tong University
2022-2025
Heilongjiang University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2025
University of Sheffield
2024
Hebei Medical University
2014-2024
Second Hospital of Hebei Medical University
2014-2024
First Affiliated Hospital of Zhengzhou University
2022-2024
Tianjin Medical University General Hospital
2022-2024
ShanghaiTech University
2021-2023
Zhengzhou University
2022-2023
Abstract Background Long-term monitoring of Electrocardiogram (ECG) recordings is crucial to diagnose arrhythmias. Clinicians can find it challenging arrhythmias, and this a particular issue in more remote underdeveloped areas. The development digital ECG AI methods could assist clinicians who need arrhythmias outside the hospital setting. Methods We constructed large-scale Chinese benchmark dataset using data from 272,753 patients collected January 2017 December 2021. contains all common...
NASH is a highly prevalent metabolic syndrome that has no specific approved agents up to now. BBBP, which mainly contains bile acids, possess various pharmacological properties and some acids are available for treatment. Herein, the therapeutic effects underlying mechanisms of BBBP against were systemically evaluated. In this study, mice received an HFHS diet over 20-week period induce with or without intervention used evaluate effect NASH. Our results demonstrated attenuated hepatic...
We propose a knowledge-enhanced electrocardiogram (ECG) diagnosis foundation model (KED) that utilizes large language models to incorporate domain-specific knowledge of ECG signals. This is trained on 800,000 ECGs from nearly 160,000 unique patients. Despite being single-center data, KED demonstrates exceptional zero-shot performance across various regions, including different locales in China, the United States, and other regions. spans all age groups for conditions such as morphological...
Contrast-induced acute kidney injury (CI-AKI) is a severe complication caused by intravascular applied radial contrast media (CM). Pyroptosis lytic type of cell death inherently associated with inflammation response and the secretion pro-inflammatory cytokines following caspase-1 activation. The aim present study was to investigate protective effects acetylbritannilactone (ABL) on iopromide (IOP)-induced renal failure reveal underlying mechanism. In vivo in vitro, IOP treatment damage...
Autophagy is a major means for the elimination of protein inclusions in neurons neurodegenerative diseases such as Parkinson’s disease (PD). Yet, mechanism autophagy other brain cell type, glia, less well characterized and remains largely unknown. Here, we present evidence that PD risk factor, Cyclin-G-associated kinase (GAK)/ Drosophila homolog Auxilin (dAux), component glial autophagy. The lack GAK/dAux increases autophagosome number size adult fly glia mouse microglia, generally...
Abstract Background Jianwei Xiaoshi oral liquid (JWXS), a classical traditional prescription comprising various edible medicinal plants, has demonstrated significant efficacy in treating paediatric indigestion. It originates from Jianpi Pill, which is developed the Ming Dynasty and nourishes spleen regulates gastrointestinal function. However, specific molecular mechanisms involved remain unclear. Methods To elucidate material base of JWXS its underlying mechanism dyspepsia, UHPLC–Q–Orbitrap...
Hepatocellular carcinoma(HCC) has a high mortality and morbidity rate seriously jeopardizes human life. Chemicals chemotherapeutic agents have been experiencing problems such as side effects drug resistance in the treatment of HCC, which cannot meet needs clinical treatment. Therefore, finding novel low-toxicity high-efficiency anti-hepatocellular carcinoma drugs exploring their mechanisms action become current to be solved HCC. Several studies reported anticancer inotodiol. This study...
Dihuang Baoyuan Granules is a prescription endorsed by HU Tianbao, renowned and elderly Chinese medicine practitioner from Beijing, has demonstrated definite clinical efficacy. The composition of this intricate as it includes 7 distinct herbal medicines. This study aims to analyze the chemical Granules, evaluate its efficacy in treatment diabetes distribution drug components plasma, liver, kidney after administration. findings will serve reference for future research on pharmacodynamic...
IgD multiple myeloma (MM) is a rare type of MM, accounting for about 1%-2% all MMs. MM always causes kidney damage and even leads to renal failure, which the most common complication. This study aimed explore risk factors prognosis patients.From March 2018 November 2021, 85 patients with diagnosed first time at First Affiliated Hospital Zhengzhou University were included in this study. We collected information on clinical features laboratory examinations. Patients divided into impairment...