A5102857934- interferon and immune responses
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Influenza Virus Research Studies
- Herpesvirus Infections and Treatments
- Virus-based gene therapy research
- Hepatitis B Virus Studies
- Immune Response and Inflammation
- Viral Infections and Immunology Research
- Hydrology and Sediment Transport Processes
- Soil erosion and sediment transport
- Neurological Disease Mechanisms and Treatments
- Virology and Viral Diseases
- Endoplasmic Reticulum Stress and Disease
- Antimicrobial Peptides and Activities
- Noise Effects and Management
- Immunotherapy and Immune Responses
- Poxvirus research and outbreaks
- Respiratory viral infections research
- Immune Cell Function and Interaction
- Traditional Chinese Medicine Analysis
- Genomics, phytochemicals, and oxidative stress
- Curcumin's Biomedical Applications
- Aeolian processes and effects
- Medicinal Plants and Bioactive Compounds
Fujian University of Traditional Chinese Medicine
2025
Shaanxi University of Science and Technology
2008-2024
Southeast University
2016-2024
Guangzhou Medical University
2019-2024
University of Chinese Academy of Sciences
2014-2024
Shanghai University of Traditional Chinese Medicine
2024
Suzhou Research Institute
2024
Institute of Microelectronics
2022-2024
Seventh People's Hospital of Shanghai
2024
Wuhan University of Technology
2024
Objectives We aim to investigate the prevalence of respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) among pediatric patients with acute tract illness (ARTI) in southern China both pre- post-COVID-19 pandemic, as well identify associated risk factors for severe infections. Methods The study conducted a real-time PCR analysis on hospitalized children ARTI from 2012 2023, specifically targeting RSV, hMPV, other pathogens. Additionally, demographic data was collected during...
ABSTRACT Recombinant vesicular stomatitis virus (rVSV) has shown great potential as a new viral vector for vaccination. However, the prototypic rVSV described previously was found to be insufficiently attenuated clinical evaluation when assessed neurovirulence in nonhuman primates. Here, we describe attenuation, neurovirulence, and immunogenicity of vectors expressing human immunodeficiency type 1 Gag. These were by combinations following manipulations: N gene translocations (N4), G...
The majority of hepatitis C virus (HCV) infection develops chronic infection, which causes steatosis, cirrhosis and hepatocellular carcinoma. However, understanding HCV chronicity pathogenesis is hampered by its narrow host range, mostly restricted to human chimpanzee. Recent endeavour infect a variety humanized mice has not been able achieve persistent unless the essential innate immune responsive genes are knocked out. Nevertheless, such immune-compromised still lacked infection-induced...
ABSTRACT A variety of rational approaches to attenuate growth and virulence vesicular stomatitis virus (VSV) have been described previously. These include gene shuffling, truncation the cytoplasmic tail G protein, generation noncytopathic M mutants. When separately introduced into recombinant VSV (rVSV), these mutations gave rise viruses distinguished from their “wild-type” progenitor by diminished reproductive capacity in cell culture and/or reduced cytopathology decreased pathogenicity...
ABSTRACT Similar to other positive-sense, single-stranded RNA viruses, hepatitis C virus (HCV) replicates its genome in a remodeled intracellular membranous structure known as the web (MW). To date, process of MW formation remains unclear. It is generally acknowledged that HCV nonstructural protein 4B (NS4B) can induce through interaction with cytosolic endoplasmic reticulum (ER) membrane. Many host proteins, such phosphatidylinositol 4-kinase IIIα (PI4KIIIα), have been identified critical...
Our present study focused on assessing whether Sinomenine (SIN) could attenuate sepsis-induced acute lung injury (ALI).The mice were conditioned with SIN 1 h before intraperitoneal injection of lipopolysaccharide (LPS). Lung wet/dry (W/D) ratio, inflammatory level in bronchoalveolar lavage fluid (BALF), malondialdehyde (MDA) levels, superoxide dismutase (SOD) activity and cytokines production detected. The expression nuclear factor erythroid 2-like 2 (Nrf2) autophagy-related proteins...
Epidemiological studies have indicated that noise exposure is associated with an increased risk of type 2 diabetes mellitus (T2DM). However, the nature connection between and T2DM remains to be explored.We explored whether how affects glucose homeostasis in mice as initial step toward development.Male ICR were randomly assigned one four groups: control group three groups (N20D, N10D, N1D), which animals exposed white at 95 decibel sound pressure level (dB SPL) for 4 hr per day 20 successive...
ABSTRACT Several members of the phospholipase family have been reported to be involved in hepatitis C virus (HCV) replication. Here, we identified another phospholipase, phosphatidylserine-specific A1 (PLA1A), as a host factor HCV assembly. PLA1A was upregulated by infection, and knockdown significantly reduced J399EM (genotype 2a) propagation at assembly step but not entry, RNA replication, protein translation steps life cycle. Protein localization interaction analysis further revealed role...
Because it is highly contagious, the influenza A virus (IAV) has potential to cause pandemics in humans. The emergence of drug-resistant strains requires development new chemical therapeutics. Oroxylin (OA) a flavonoid which been shown have antioxidant and antitumor effects. However, intensive studies OA fights against different underlying antiviral mechanisms not reported. In our study, activities cells mice, preliminary were investigated. Our data show that can inhibit A/FM/1/47 (H1N1),...
Abstract Non-small cell lung cancer (NSCLC), including adenocarcinoma and squamous carcinoma, is the leading cause of death from malignancies has a poor prognosis due to metastasis. Suppressor cytokine signalling-2 (SOCS2), feedback inhibitor signalling, been shown be involved in growth control. Here, we show that SOCS2 were significantly downregulated tumour foci NSCLC patients. The expression levels correlated with clinical stage, lymph node metastasis, histological subtype survival time....
Background and Aims The regulation of hepatic very‐low‐density lipoprotein (VLDL) secretion is vital for lipid metabolism whose pathogenetic status involved in fatty liver disease dyslipidemia seen steatosis. Accumulated evidence suggest that apolipoprotein E (ApoE) closely related to VLDL secretion. Here, we report the expression patatin‐like phospholipase domain containing protein 7 (PNPLA7) strongly induced by steatosis positively correlates with plasma triacylglycerol (TAG) levels human...
The aim of this study was to develop a regional landslide stability analysis method considering the combined impact rainfall and roots vegetation in densely vegetated areas. A typical mountainous watershed Nanling National Nature Reserve South China chosen as area. First, unmanned aerial vehicle (UAV) used obtain surface element information including topography, vegetation, landslides. Five main plant species were identified. RipRoot model then calculate additional cohesion these five...
Histone deacetylase 9 (HDAC9) regulates hepatic gluconeogenesis by deacetylating Forkhead box O 1 (FoxO1). HDAC9 upregulation is involved in hepatitis C virus (HCV)-associated exaggerated gluconeogenesis. Herein, we found addition to FoxO1, also other gluconeogenic transcription factors, including peroxisomeproliferator-activated receptor-γ coactivator-1α (PGC-1α), cyclic AMP-responsive element-binding protein (CREB), and glucocorticoid receptor (GR). Unlike which regulated...
Epidemiological studies have revealed that noise exposure was associated with an increased risk of type 2 diabetes mellitus (T2DM). However, the exact nature association remains to be elucidated. The present study is designed examine effects chronic on development T2DM in combination a high-fat-diet (HFD) mice. Here we show at 85 dB SPL (4 h /day, below safety limit for occupational exposure) exaggerated multiple metabolic abnormalities induced by HFD C57BL/6J male mice, including worsened...