A5102013132- Metabolism and Genetic Disorders
- Immune cells in cancer
- Cancer-related gene regulation
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Genomics and Rare Diseases
- Epigenetics and DNA Methylation
- Cancer, Lipids, and Metabolism
- Prenatal Screening and Diagnostics
- Circular RNAs in diseases
- Genital Health and Disease
- Biomedical Text Mining and Ontologies
- Sexual Differentiation and Disorders
- Bladder and Urothelial Cancer Treatments
- Cancer Research and Treatments
- Metabolism, Diabetes, and Cancer
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
- Folate and B Vitamins Research
- FOXO transcription factor regulation
- Pancreatic function and diabetes
- Genetic Associations and Epidemiology
- Genomic variations and chromosomal abnormalities
- Biomarkers in Disease Mechanisms
Heze University
2025
Nanjing Medical University
2016-2025
Affiliated Hospital of Qingdao University
2012-2024
Nanjing Maternity and Child Health Care Hospital
2016-2024
Weifang People's Hospital
2023-2024
Weifang Medical University
2023-2024
Qingdao University
2012-2024
Hebei Medical University
2021-2024
Fourth Hospital of Hebei Medical University
2021-2024
Sun Yat-sen Memorial Hospital
2022-2023
Cancer-associated fibroblasts (CAFs), the predominant stromal cell of tumor microenvironment (TME), play an important role in progression and immunoregulation by remodeling extracellular matrix (ECM) secreting cytokines. However, little is known about details underlying mechanism bladder cancer.Bioinformatics analysis was performed to analyze prognostic value CAFs CXCL12 using GEO, TCGA SRA databases. The effects on cancer were investigated through vitro vivo assays. biological effect PDL1...
Abstract Background Exosomes are deemed to be an important tool of intercellular communicators in cancer cells. Our study investigated the role PRR34 long non-coding RNA antisense 1 (PRR34-AS1) regulating exosome secretion hepatocellular carcinoma (HCC) Methods Quantitative real-time polymerase chain reaction (RT-qPCR) analyzed expression PRR34-AS1. We assessed function PRR34-AS1 on biological changes THLE-3 cells and HCC The downstream interaction between RNAS was by mechanistic...
Abstract Background In the fast-paced modern life, sleep quality has become a key indicator for measuring individual health and of life. The mechanisms by which physical exercise influences through psychological behavioral pathways, particularly via smartphone dependence, remain underexplored. Objective To investigate mediating roles mobile phone dependence duration in relationship between quality, using chain mediation model. Methods A questionnaire survey was conducted on 1905 college...
Abstract Background Lysosomal storage disorders (LSDs) have a relatively high incidence among rare diseases and can lead to severe consequences if not treated promptly. However, many countries regions included these in their newborn screening programs, resulting missed early detection, underdiagnosis, delayed treatment. Newborn genomic (NBGS) has shown good effectiveness for traditional biochemical diseases; however, its LSDs yet been evaluated the general population. Methods To evaluate...
Histone deacetylase 9 (HDAC9) regulates hepatic gluconeogenesis by deacetylating Forkhead box O 1 (FoxO1). HDAC9 upregulation is involved in hepatitis C virus (HCV)-associated exaggerated gluconeogenesis. Herein, we found addition to FoxO1, also other gluconeogenic transcription factors, including peroxisomeproliferator-activated receptor-γ coactivator-1α (PGC-1α), cyclic AMP-responsive element-binding protein (CREB), and glucocorticoid receptor (GR). Unlike which regulated...
ALDH1A1 is one of the classical stem cell markers for bladder cancer. Lysine 2-hydroxyisobutyrylation (Khib) a newfound modification to modulate protein expression, and underlying mechanisms how was regulated by Khib in cancer remains unknown. Here, showed decreased K260hib modification, as identified omics Decreasing expression significantly suppressed proliferation, migration invasion cells. Moreover, responsible activity cancer, which HDAC2/3. Higher on promotes degradation through...
Abstract Background Newborn genetic screening (NBGS) based on next-generation sequencing offers enhanced disease detection and better rates than traditional newborn screening. However, challenges remain, especially around reporting the NBGS carrier results. Therefore, we aimed to investigate parents’ views reports in China. Methods We distributed a survey querying demographic information, knowledge perceptions of NBGS, impact total 2930 parents, their decision-making parents newborns...
Osteoporosis often occurs with carotid atherosclerosis and causes contradictory calcification across tissue in the same patient, which is called "calcification paradox". Circulating monocytes may be responsible for this unbalanced ectopic calcification. Here, we aimed to show how CD14+ contribute pathophysiology of coexisting postmenopausal osteoporosis atherosclerosis. We comprehensively analyzed data from mRNA array dataset GSE56814 scRNA-seq GSM4423510. Carotid were obtained GSE23746...
Abstract Background Hyperphenylalaninemia (HPA) is the most common amino acid metabolic disease involving phenylalanine hydroxylase (PAH, OMIM*612,349) deficiency or coenzyme tetrahydrobiopterin (BH4) deficiency. Patients with severe HPA often have a difficult life. Early diagnosis of before development symptoms possible via neonatal screening, facilitating appropriate treatment and reducing mortality disability rates. This study revealed prevalence, mutational phenotypic spectrum, prognosis...
Abstract Solid tumors are characterized by enhanced metabolism of lipid, particularly cholesterol, inspiring the exploration metabolic therapy through cholesterol oxidase (COD)‐mediated deprivation. However, therapeutic efficacy COD is limited due to hypoxic tumor microenvironment and protective autophagy triggered Herein, a combination for metabolically treating solid in conjunction with molybdenum oxide nanodots (MONDs), which serve as both potent oxygen generators inhibitors, reported....
Abstract Purpose Newborn screening (NBS) applications are limited as they can only cover a few genetic diseases and may have false positive or negative rates. A new detection program called newborn (NBGS) has been designed to address the potential defects of NBS. This study aimed investigate perceptions, acceptance, expectations childbearing people related NBGS provide basis for targeted improvement in carried out Hospitals. Methods questionnaire with 20 items was on www.wjx.cn . Individuals...
Background Bladder cancer is characterized by a high recurrence rate and mortality, posing significant challenge to clinical management. Recently, cuproptosis, novel form of regulated cell death, has been identified as potential target for therapeutic intervention in various diseases. The contribution cuproptosis-related microRNAs (miRNAs) bladder pathogenesis, however, remains largely unexplored. Therefore, the current study aims construct miRNA signature related cuproptosis predicting...
Background: Hepatocellular carcinoma (HCC) is a horrible malignancy derived from liver. Circular RNAs (circRNAs) act important roles in the pathogenesis and progression of human diseases, including HCC. The current assay intended to investigate function circRNA low-density lipoprotein receptor (circ_LDLR) HCC clarify underlying mechanism. Materials Methods: Expression circ_LDLR, microRNA (miR)-7 ring finger protein 38 (RNF38) was determined by quantitative real-time PCR (qRT-PCR) or Western...
A Disintegrin and Metalloproteinase (ADAM) with Thrombospondin Motif (ADAMTS) have been reported potentially involved in bone metabolism related to mineral density. This Mendelian Randomization (MR) analysis was performed determine whether there are causal associations of serum ADAM/ADAMTS BMD rid confounders.The genome-wide summary statistics four site-specific measurements were obtained from studies individuals European ancestry, including forearm (n = 8,143), femoral neck 32,735), lumbar...
Interstitial cystitis is a diagnosis of exclusion due to the complexity its etiology and pathology, which chronic disease with an unknown etiology. To our knowledge, few studies were performed identify predictive biomarkers for interstitial cystitis.
To explore the pathogenicity and genotype-phenotype correlation of c.158G>A variant phenylalanine hydroxylase (PAH) gene among patients with PAH deficiency.
Background: Congenital adrenal hyperplasia (CAH) is a group of autosomal recessive disorders encompassing enzyme deficiencies in the steroidogenesis pathway that leads to impaired cortisol biosynthesis. 21-hydroxylase deficiency (21-OHD) most common type CAH. Severe cases 21-OHD may result death during neonatal or infancy periods sterility later life. The early detection and timely treatment are essential. This study aimed summarize clinical genotype characteristics patients detected by...