A5074335599- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer-related molecular mechanisms research
- Peripheral Neuropathies and Disorders
- MicroRNA in disease regulation
- Inflammasome and immune disorders
- Cytokine Signaling Pathways and Interactions
- Acute Myeloid Leukemia Research
- Hereditary Neurological Disorders
- Acute Ischemic Stroke Management
- Muscle Physiology and Disorders
- Video Analysis and Summarization
- Hematological disorders and diagnostics
- Protease and Inhibitor Mechanisms
- Acupuncture Treatment Research Studies
- Psoriasis: Treatment and Pathogenesis
- Advanced Image and Video Retrieval Techniques
- Sphingolipid Metabolism and Signaling
- Intracerebral and Subarachnoid Hemorrhage Research
- Whipple's Disease and Interleukins
- Cytomegalovirus and herpesvirus research
- Circular RNAs in diseases
- Ferroptosis and cancer prognosis
- Genetic Neurodegenerative Diseases
- Glioma Diagnosis and Treatment
- Bone and Joint Diseases
First Affiliated Hospital of Harbin Medical University
2016-2025
Harbin Medical University
2016-2025
Guangdong Province Women and Children Hospital
2025
Ta Solutions (China)
2025
China XD Group (China)
2024
Third Affiliated Hospital of Harbin Medical University
2024
Hefei First People's Hospital
2024
Fujian Medical University
2024
Qingdao University
2023
The Third Affiliated Hospital of Zhejiang Chinese Medical University
2022
Abstract Arterial occlusion-induced ischemic stroke (IS) is a highly frequent subtype. Nuclear factor erythroid 2-related 2 (NRF2) transcription that modulates antioxidant genes. Its role in IS still unelucidated. The current study focused on constructing transient middle cerebral artery occlusion (tMCAO) model for investigating the NRF2-related mechanism underlying ischemia/reperfusion (I/R) injury. Each male C57BL/6 mouse was injected with/with no specific NRF2 activator post-tMCAO....
Abstract In the current study, we aimed to investigate whether disulfiram (DSF) exerts a neuroprotective role in cerebral ischemiareperfusion (CI-RI) injury by modulating ferredoxin 1 (FDX1) regulate copper ion (Cu) levels and inhibiting inflammatory responses. To simulate CI-RI, transient middle artery occlusion (tMCAO) model C57/BL6 mice was employed. Mice were administered with or without DSF before after tMCAO. Changes infarct volume tMCAO observed using TTC staining. Nissl staining...
In this paper, we present an effective framework for scene detection and structure analysis sports videos, using tennis baseball as examples. Sports video can be characterized by its predictable temporal syntax, recurrent events with consistent features, a fixed number of views. Our approach combines domain-specific knowledge, supervised machine learning techniques, automatic feature at multiple levels. Real time processing performance is achieved utilizing compressed-domain techniques. High...
The dystroglycan complex is a membrane-spanning composed of two subunits, α- and β-dystroglycan. α-dystroglycan cell surface peripheral membrane protein which binds to the extracellular matrix (ECM), whereas β-dystroglycan an integral anchors membrane. provides tight link between ECM Dysfunction has commonly been implicated in molecular pathogenesis severe forms hereditary neuromuscular diseases, including Duchenne muscular dystrophy, Fukuyama-type congenital dystrophy sarcoglycanopathy...
Ischemic brain injury is acute local inflammation, leading to accumulation of pro-inflammatory cytokines. Cytokines influence the recruitment leucocytes and play a key role in inflammatory processes. Recently, number studies have demonstrated close relationship between ischemia Interleukin-17 (IL-17) newly identified T-cell-specific cytokine. In this study, we evaluated source action IL-17 over course cerebral rats (Sprague-Dawley) humans. The levels ischemic hemisphere human brain, which...
Ischemic stroke remains a significant cause of death and disability in industrialized nations. Janus tyrosine kinase (JAK) signal transducer activator transcription (STAT) the JAK2/STAT3 pathway play important roles downstream regulation ischemic stroke-related inflammatory neuronal damage. Recently, microRNAs (miRNAs) have emerged as major regulators cerebral injury; therefore, authors aimed to investigate underlying molecular mechanism between miRNAs stroke, which may provide potential...
Immune infiltration plays an important role in the course of ischemic stroke (IS) progression. Cuproptosis is a newly discovered form programmed cell death. To date, no studies on mechanisms by which cuproptosis-related genes regulate immune IS have been reported.IS-related microarray datasets were retrieved from Gene Expression Omnibus (GEO) database and standardized. was extracted quantified based processed gene expression matrix. The differences between group normal as well correlation...
Stroke still has a high incidence with tremendous public health burden and it is leading cause of mortality disability. However, biomarkers for early diagnosis are absent the metabolic alterations associated ischemic stroke not clearly understood. The objectives this case-control study to identify serum explore stroke.Metabonomic analysis was performed using ultra-performance liquid chromatography quadrupole time-of-flight tandem mass spectrometry multivariate statistical employed 60...
Diabetes-associated cognitive decline (DACD) is one of the complications diabetes and leads to impairment an increased risk dementia. However, exact mechanism DACD has not been fully characterized, a successful therapy for this issue established. This study aimed detect anti-apoptotic anti-inflammatory effects hydrogen sulfide (H2S) on DACD.We used behavioural scoring method, Western blot, TUNEL staining immunofluorescence investigate expression mitochondrial apoptotic pathway IL-23/IL-17...
Leucine-rich α2 glycoprotein 1 (LRG1) has been shown to be aberrantly expressed in multiple human malignancies. However, the biological functions of LRG1 glioblastoma remain unknown. Here, we report for first time role development based on preliminary vitro and vivo data. We confirmed expression cell lines. Next, investigate tumorigenesis glioblastoma, a short hairpin RNA (shRNA) construct targeting mRNA was transfected into U251 cells generate line with stably silenced expression. The...
Abstract Background Although RNA-binding proteins play an essential role in a variety of different tumours, there are still limited efforts made to systematically analyse the (RBPs) survival colorectal cancer (CRC) patients. Methods Analysis CRC transcriptome data collected from TCGA database was conducted, and RBPs were extracted CRC. R software applied differentially expressed genes (DEGs) RBPs. To identify related pathways perform functional annotation RBP DEGs, Gene Ontology (GO)...
Background Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS) mediated by autoimmunity. No objective clinical indicators are available for diagnosis and prognosis MS. Extracellular proteins most glycosylated likely to enter into body fluid serve as potential biomarkers. Our work will contribute in-depth study functions extracellular discovery Methods MS expression profiling data human brain was downloaded from Gene Expression Omnibus (GEO)....
5550 Background: BAT8006 is an antibody-drug conjugate targeting to folate receptor α (FRα). In this phase 1 study, the authors investigated in subjects with solid tumors. Methods: Subjects advance tumor received on day of a 21-day cycle until subject intolerance or disease progression. The study objectives were tolerability, safety, pharmacokinetic characteristics, immunogenicity, preliminary efficacy. Results: As January 5, 2024, 100 Chinese advanced allocated into six cohorts, including...
This study investigated the role of microRNA miR-298 and its target Act1 in ischemic stroke.Cell viability was assessed with 3-(4,5-dimethythiazol-2- yl)-2,5-diphenyl tetrazolium bromide assay. Apoptotic cells were detected by flow cytometry, mRNA protein expression quantitative real-time PCR western blotting, respectively. The regulatory relationship between evaluated luciferase To clarify following stroke, transcript knocked down short interfering RNA. vitro findings validated a mouse...